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5 results on '"Slonimskaya E"'

4. Features of Proteasome Functioning in Malignant Tumors.

Author

Kondakova, I. V., Spirina, L. V., Shashova, E. E., Kolegova, E. S., Slonimskaya, E. M., Kolomiets, L. A., Afanas'ev, S. G., and Choinzonov, Y. L.

Subjects
PROTEASOMES, UBIQUITIN, PROTEOLYSIS, PROTEIN metabolism, CHYMOTRYPSIN
Abstract

Proteasome ubiquitin system is the important system of intracellular proteolysis. The activity of the proteasomes may undergo changes during cancer development. We studied the chymotrypsin-like activity of proteasomes, their subunit composition, and their association with tumor stage in breast cancer, head and neck squamous cell carcinoma, endometrial cancer, renal cancer, bladder cancer, stomach cancer, ovarian cancer, and colorectal cancer. The increase in chymotrypsin-like activity of proteasomes and decrease in total proteasome pool compared with adjacent tissues were shown in all malignant tumors excluding kidney cancer. The increase in chymotrypsin-like activity of proteasomes was found in primary tumors with all types of metastasis: lymphogenous of head and neck squamous cell carcinoma, intraperitoneal metastasis of ovarian cancer, hematogenous metastasis colorectal cancer. The exception was kidney cancer, in which there was a decrease in chymotrypsin-like activity with distant metastasis. [ABSTRACT FROM AUTHOR]

Published
2017
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5. Changes in the Activity of Proteasomes and Calpains in Metastases of Human Lung Cancer and Breast Cancer.

Author

Shashova, E., Kolegova, E., Zav'yalov, A., Slonimskaya, E., and Kondakova, I.

Subjects
METASTASIS, PROTEASOMES, CALPAIN, CALPAIN regulation, LUNG cancer, BREAST cancer, MULTIENZYME complexes
Abstract

In patients with breast cancer and lung cancer, chymotrypsin-like and caspase-like activities of proteasomes and total activity of calpains in the primary tumor nodes and lymphogenic metastasis are elevated in comparison with the corresponding normal tissues. The development of lymphogenic metastases of breast cancer and lung cancer was associated with opposite change in caspase-like activity of proteasomes. These results can be useful for the development of methods for evaluation of aggressiveness of breast and lung cancer. [ABSTRACT FROM AUTHOR]

Published
2017
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