1. LDL-apheresis-induced remission of focal segmental glomerulosclerosis recurrence in pediatric renal transplant recipients.
- Author
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Shah L, Hooper DK, Okamura D, Wallace D, Moodalbail D, Gluck C, Koziell A, and Zaritsky JJ
- Subjects
- Allografts pathology, Child, Child, Preschool, Combined Modality Therapy methods, Creatinine urine, Disease Progression, Female, Follow-Up Studies, Glomerular Filtration Rate, Glomerulosclerosis, Focal Segmental blood, Glomerulosclerosis, Focal Segmental diagnosis, Glomerulosclerosis, Focal Segmental pathology, Humans, Infant, Kidney Failure, Chronic surgery, Kidney Glomerulus pathology, Male, Proteinuria blood, Proteinuria diagnosis, Proteinuria pathology, Pulse Therapy, Drug, Recurrence, Remission Induction methods, Retrospective Studies, Treatment Outcome, Blood Component Removal methods, Glomerulosclerosis, Focal Segmental therapy, Kidney Transplantation, Lipoproteins, LDL blood, Methylprednisolone Hemisuccinate administration & dosage, Proteinuria therapy
- Abstract
Background: Focal segmental glomerulosclerosis (FSGS) in pediatric patients is typically difficult to treat and will progress to end-stage renal disease (ESRD) in about 10% of cases. Following kidney transplantation, FSGS can recur in up to 56% of renal allografts-with a near 100% recurrence in subsequent transplants., Methods: Four different pediatric centers across the USA and the UK employed a protocol using LDL-apheresis (LDL-A) and pulse solumedrol to treat recurrent FSGS after transplantation in seven patients. All the patients included in this series demonstrated immediate, or early, recurrence of FSGS, which clinically presented as nephrotic-range proteinuria within hours to days after implantation of the kidney., Results: All patients experienced reductions in urinary protein to creatinine ratios resulting in partial or complete remission. All patients demonstrated improvements in their estimated GFRs at their most recent follow-up since LDL-A discontinuation., Conclusions: This case series describes the successful treatment, across four different pediatric centers, of seven pediatric patients with recurrent post-transplant FSGS using the Liposorber® LA-15 in combination with pulse solumedrol.
- Published
- 2019
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