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Start Over Author "Florine Polus" Topic psoriasis
3 results on '"Florine Polus"'

1. Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion

Author

Julia K. Mader, Frank Sinner, Gerard Bruin, Katrin I. Tiffner, Yi Cheng, Florine Polus, Christian Loesche, Christian Dragatin, Claudio Calonder, Manfred Bodenlenz, Birgit Aigner, Thomas R. Pieber, Ralph Woessner, and Maria Ratzer

Subjects
medicine.drug_class, business.industry, Dermatology, Pharmacology, Open flow, Monoclonal antibody, medicine.disease, 030226 pharmacology & pharmacy, Biochemistry, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Interstitial fluid, Psoriasis, medicine, Secukinumab, Interleukin 17, business, Molecular Biology, Perfusion
Published
2015
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2. β-Defensin 2 is a responsive biomarker of IL-17A-driven skin pathology in patients with psoriasis

Author

Claudio Calonder, Thomas Peters, Gerard Bruin, Manfred Bodenlenz, Dhavalkumar D. Patel, Florine Polus, Frank Kolbinger, Marie-Anne Valentin, Philip Jarvis, Birgit Aigner, Frank Sinner, Thomas R. Pieber, David M. Lee, Christian Loesche, Yi Cheng, and Xiaoyu Jiang

Subjects
rheumatoid arthritis, 0301 basic medicine, Adult, Male, beta-Defensins, microperfusion, Immunology, multiple sclerosis, medicine.disease_cause, Antibodies, Monoclonal, Humanized, Autoimmunity, Autoimmune Diseases, 030207 dermatology & venereal diseases, 03 medical and health sciences, Psoriatic arthritis, 0302 clinical medicine, Psoriasis Area and Severity Index, Psoriasis, ankylosing spondylitis, medicine, Immunology and Allergy, Humans, Skin, psoriatic arthritis, business.industry, secukinumab, autoimmunity, Interleukin-17, Antibodies, Monoclonal, medicine.disease, dermal interstitial fluid, IL-17, 030104 developmental biology, β-defensin 2, Rheumatoid arthritis, biomarker, Biomarker (medicine), Secukinumab, Female, Interleukin 17, business, Biomarkers
Abstract

BackgroundIL-17A is a key driver of human autoimmune diseases, particularly psoriasis.ObjectiveWe sought to determine the role of IL-17A in psoriasis pathogenesis and to identify a robust and measurable biomarker of IL-17A–driven pathology.MethodsWe studied 8 healthy subjects and 8 patients with psoriasis before and after administration of secukinumab, a fully human anti–IL-17A mAb, and used a combination of classical techniques and a novel skin microperfusion assay to evaluate the expression of 170 proteins in blood, nonlesional skin, and lesional skin. For validation, we also tested stored sera from 601 patients with a variety of autoimmune diseases.ResultsIL-17A was specifically expressed in lesional compared with nonlesional psoriatic skin (9.8 vs 0.8 pg/mL, P

Published
2016

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