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INTRODUCTION: Siberkondria is the behavior of people looking for information about their health on the internet in a repetitive and continuous manner. This concept is more common in the field of mental health in recent years due to the more use of technology in our daily lives. In this study, it was aimed to examine the demographic variables that affect cyberchondria behavior and to investigate the related concepts. METHODS: A total of 430 people, 254 women and 176 men, participated in this study. A questionnaire form including demographic data form, Cyberchondria Severity Scale, Anxiety Sensitivity Index-3, Intolerance to Uncertainty Scale and Somatosensory Amplification Scale was applied to the participants. RESULTS: Cyberchondria mean scores were found to be significantly higher for female participants (t(428)=3,445; p

Hyponatremia is a potentially dangerous side effect of antidepressants. Almost every antidepressant can cause hyponatremia. Duloxetine-induced hyponatremia is a side effect that is usually seen in older women. In addition to advanced age and female sex; low body weight, presence of comorbid diseases are other important risk factors for the development of hyponatremia. In this case report we present a patient with depressive disorder who developed hyponatremia with duloxetine treatment which resolved immediately after the cessation of the medication with supportive electrolyte treatment. In our case, the resolution of hyponatremia with supportive electrolyte treatment in addition to the cessation of duloxetine reminds us about the importance of monitoring sodium levels both before and after antidepressant treatment in geriatric populations., Hiponatremi, antidepresanların potansiyel olarak tehlikeli bir yan etkisidir. Hemen hemen her antidepresan hiponatremiye neden olabilir. Duloksetin kaynaklı hiponatremi genellikle yaşlı kadınlarda görülen bir yan etkidir. İleri yaş ve kadın cinsiyetine ek olarak; düşük vücut ağırlığı, komorbid hastalıkların varlığı hiponatremi gelişimi için diğer önemli risk faktörleridir. Bu olgu sunumunda, ilacın kesilmesinden hemen sonra düzelen duloksetin tedavisi ile hiponatremi gelişen depresif bozukluğu olan bir hasta sunulmaktadır. Bizim olgumuzda, duloksetin kesilmesine ek olarak, hiponatreminin destekleyici elektrolit tedavisi ile çözülmesi bize geriatrik popülasyonlarda antidepresan tedavisinden önce ve sonra sodyum seviyelerinin izlenmesinin önemini hatırlatmaktadır.

Objective We aimed to compare the effectiveness of extended-release naltrexone (XR-NTX) implant and sublingual buprenorphine-naloxone (BUP-NX) in relapse prevention in opiate use disorder (OUD). Methods Medical records of 400 patients who were treated for OUD between 2016 and 2020 were retrospectively evaluated concerning sociodemographic and clinical characteristics and abstinence duration with either BUP-NX (192 patients) or XR-NTX (208 patients) as maintenance treatments. Results The median age of patients using BUP-NX was 25.00, and the median age of patients using XR-NTX was 25.50 (p = .785). The ratio of female patients in the BUP-NX group and the XR-NTX group was 7.3% (n = 14) and 6.7% (n = 14), respectively. A significantly higher abstinence time was observed in the BUP-NX group (median = 4 months) than in the XR-NTX group (median = 3 months) (p = .015). Liver function tests were within the normal ranges at the three time points, which were just before the beginning and in the first and third months of treatment. Conclusions These findings suggest that BUP-NX might be more effective than XR-NTX in preventing relapse in OUD and both drugs are safe for the liver. Prospective randomized studies are needed to replicate our results.

BACKGROUND AND OBJECTIVES Substance use and addictive disorders are among the most significant public health concerns, particularly during adolescence. The current study aims to investigate internet gaming disorder, social media addiction, and loneliness levels in adolescents and youths with substance use. Methods: The study group consisted of 93 adolescents and youths aged 15-24 who presented to the Alcohol and Substance Addiction Research and Application Center or the Child and Adolescent Mental Health and Diseases outpatient clinic for substance use. Ninety-one healthy volunteers who did not use substances during any period of their lives participated as a control group. The participants fulfilled the Social Media Addiction Scale (SMAS), Internet Gaming Disorder Scale - Short-Form (IGDS9-SF), UCLA Loneliness Scale (UCLA-LS), and Drug Use Disorders Identification Test - Extended (DUDIT-E). Results: The symptoms of internet gaming disorder were significantly lower in the patient group compared with the control group. Although it was not significant, social media addiction was higher in the patient group than in the control group. The experience of loneliness was significantly higher in the patient group than in the control group. A significant negative correlation was found between treatment motivation and loneliness. Conclusions: School guidance teachers should monitor children who do not have friends or are lonely and be aware of the potential for substance use because it can emerge as a method of coping with the feeling of loneliness among adolescents. In future studies, investigating comprehensive factors contributing to different addictive behaviors may help to clarify the co-occurrence.

Internet has become an important source of health information that enables people to access a large portion of medical information. Cyberchondria is defined as behavior seeking information about health from the Internet. It can be mentioned as an internet-mediated version of hypochondriasis. It is emphasized that health anxiety is at the forefront in the etiology. Information pollution on the Internet is an important risk factor. There are no diagnostic criteria. It is not included in the DSM classification. Although there are various assessment scales, the most commonly used assessment tool is the Cyberchondria Severty Scale. It is a psychometric scale with 34 questions to measure the level of cyberchondria. Psychoeducation is the main approach in the treatment and no specific pharmacological treatment has been defined., İnternet tıbbi bilgilerin büyük bir kısmına insanların erişimini sağlayan önemli bir sağlık bilgi kaynağı haline gelmiştir. Siberkondria, hipokondriyazın dijital bir versiyonu olan, bir kişinin sağlığına ilişkin kaygı ile beslenen ve bu belirli kaygıyı güçlendiren çevrimiçi sağlıkla ilgili bilgi arayışı olarak tanımlanmaktadır. Son dönemde giderek sıklığı artmaktadır. Etyolojisinde sağlık kaygısının ön planda olduğu vurgulanmaktadır. Çevrimiçi bilgi kirliliği önemli bir risk faktörüdür. Tanı kriterleri henüz oluşturulmamış olup, tek değerlendirme aracı Siberkondri Şiddet Ölçeği’dir. Siberkondria düzeyini ölçmeye yönelik 34 soruluk 2014’te geliştirilmiş psikometrik bir ölçektir. Tedavisinde ise temel yaklaşım psikoeğitim olup belirli bir farmakolojik tedavi tanımlanmamıştır.

Introduction Current evidence suggests that pro-inflammatory cytokines, particularly tumor necrosis factor alpha (TNF-α) may play an important role in the pathophysiology of bipolar disorder (BD). Our study aims to compare BD patients and controls in terms of serum TNF-α, soluble tumor necrosis factor receptor 1 and soluble tumor necrosis factor receptor 2 (sTNF-R1, sTNF-R2) levels in different phases of BD. Methods Eighty-three patients with BD type 1 (27 manic, 22 depressive and 34 euthymic) and twenty-nine healthy controls were included in the study. Serum levels of TNF-α, sTNF-R1, sTNF-R2 levels were evaluated with ELISA kit. Results Levels of sTNF-R1 were showed a statistically significant difference between groups. Levels of sTNF-R1 were higher in depression or mania patients than euthymia patients and control subjects. A statistically significant difference in the serum level of sTNF-R1 between patients in acute episode (mania and depression) group and stabile (patients in euthymic episode and controls) group was found in logistic regression analysis. The probability of having acute episode increased threefold for each unit increase in serum level of sTNF-R1. There was no statistically significant difference between the mean serum values of TNF-α and sTNF-R2 between the groups. Conclusions sTNF-R1 production was different between acute episode patients and controls or stable BD patients. The result of this study confirms that TNF-R1 may be a state marker representing disease activity for BD.

Objective: The aim of this study is to retrospectively compare the efficacy of long acting naltrexone (XR-NTX) and oral naltrexone (O-NTX) treatment in alcohol use disorder patients. Methods: In the study, retrospective data including sociodemographic characteristics, treatment continuation rates, mean treatment duration (duration of abstinence) and liver function test results were scanned from the medical records and then analyzed in a group of 16 patients and a group of 27 patients who were put on XR-NTX and O-NTX treatments, respectively. Results: 87.5% (14 patients) of the XR-NTX treatment group and 88.9% (24 patients) of the O-NTX treatment group com-prised of male patients. The mean age in the XR-NTX group was 41.31±10.26 years; whereas it was 42.14±9.07 in the O-NTX group. Fourteen patients in the XR-NTX (87.5%) and 15 patients (55.6%) in the O-NTX group returned for control after the first admission. Thus, treatment compliance was significantly higher in the XR-NTX group than in the O-NTX group. Conclusion: An increase in treatment compliance with XR-NTX treatment was observed in the study. This study may suggest that XR-NTX is more efficient than O-NXR in the treatment of alcohol use disorder. Thus XR-NTX treatment may be a good alternative for patients with alcohol use disorder to stay on treat-ment for a longer time.