1. Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease
- Author
-
Maurits Johansson, William G. Mantyh, Renaud La Joie, Sandeep S.V. Golla, Pontus Tideman, Amelia Strom, John C. van Swieten, Ellen H. Singleton, Anke A. Dijkstra, Evi Berendrecht, Philip Scheltens, Emma M. Coomans, Antoine Leuzy, Rik Ossenkoppele, Gil D. Rabinovici, Emma E. Wolters, Leonardo Iaccarino, Erik Stomrud, Hayel Tuncel, Janne M. Papma, Lauren Edwards, Bart N.M. van Berckel, Olof Strandberg, Femke H. Bouwman, Oskar Hansson, Bruce L. Miller, Ruben Smith, Denise Visser, Yolande A.L. Pijnenburg, Neurology, Amsterdam Neuroscience - Neurodegeneration, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, and Pathology
- Subjects
Aging ,Postmortem studies ,medicine.medical_specialty ,Pathology ,Neurology ,Amyloid ,Hippocampus ,Disease ,Neurodegenerative ,Alzheimer's Disease ,Medical and Health Sciences ,03 medical and health sciences ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,Acquired Cognitive Impairment ,2.1 Biological and endogenous factors ,Medicine ,Distribution (pharmacology) ,Aetiology ,Neurodegeneration ,030304 developmental biology ,0303 health sciences ,Neurology & Neurosurgery ,Mini–Mental State Examination ,medicine.diagnostic_test ,business.industry ,Psychology and Cognitive Sciences ,Neurosciences ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Brain Disorders ,Psychiatry and Mental health ,Good Health and Well Being ,Positron emission tomography ,Neurological ,Dementia ,Mental health ,Surgery ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
ObjectiveThe clinical phenotype of the rare behavioural variant of Alzheimer’s disease (bvAD) is insufficiently understood. Given the strong clinico-anatomical correlations of tau pathology in AD, we investigated the distribution of tau deposits in bvAD, in-vivo and ex-vivo, using positron emission tomography (PET) and postmortem examination.MethodsFor the tau PET study, seven amyloid-β positive bvAD patients underwent [18F]flortaucipir or [18F]RO948 PET. We converted tau PET uptake values into standardised (W-)scores, adjusting for age, sex and mini mental state examination in a ‘typical’ memory-predominant AD (n=205) group. W-scores were computed within entorhinal, temporoparietal, medial and lateral prefrontal, insular and whole-brain regions-of-interest, frontal-to-entorhinal and frontal-to-parietal ratios and within intrinsic functional connectivity network templates. For the postmortem study, the percentage of AT8 (tau)-positive area in hippocampus CA1, temporal, parietal, frontal and insular cortices were compared between autopsy-confirmed patients with bvAD (n=8) and typical AD (tAD;n=7).ResultsIndividual regional W-scores ≥1.96 (corresponding to p0.05).ConclusionsBoth in-vivo and ex-vivo, patients with bvAD showed heterogeneous distributions of tau pathology. Since key regions involved in behavioural regulation were not consistently disproportionally affected by tau pathology, other factors are more likely driving the clinical phenotype in bvAD.
- Published
- 2021
- Full Text
- View/download PDF