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Start Over Author "Serdar Süleyman Can" Topic psychiatry and mental health
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1. Neurochemical differences between bipolar disorder type I and II in superior temporal cortices: A proton magnetic resonance spectroscopy study

Author

Semra Ulusoy Kaymak, Murat İlhan Atagün, Constance M. Moore, Elif M. Sikoglu, Ali Çayköylü, Görkem Karakaş Uğurlu, Oktay Algin, Dost Öngür, Serdar Süleyman Can, Mary L. Phillips, and Algın, Oktay

Subjects
Adult, Male, Bipolar Disorder, Phosphocreatine, Bipolar disorder, Proton Magnetic Resonance Spectroscopy, Glutamic Acid, computer.software_genre, Article, Young Adult, 03 medical and health sciences, Superior temporal gyrus, 0302 clinical medicine, Neurochemical, Nuclear magnetic resonance, Voxel, Magnetic resonance spectroscopy, medicine, Humans, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Creatine, medicine.disease, Magnetic Resonance Imaging, Cyclothymic Disorder, Temporal Lobe, Proton magnetic resonance, 030227 psychiatry, Psychiatry and Mental health, Clinical Psychology, Cross-Sectional Studies, Mood, Female, business, computer, 030217 neurology & neurosurgery, Temporal Cortices
Abstract

Background: Despite the diagnostic challenges in categorizing bipolar disorder subtypes, bipolar I and II disorders (BD-I and BD-II respectively) are valid indices for researchers. Subtle neurobiological differences may underlie clinical differences between mood disorder subtypes. The aims of this study were to investigate neurochemical differences between bipolar disorder subtypes. Methods: Euthymic BD-II patients (n = 21) are compared with BD-I (n = 28) and healthy comparison subjects (HCs, n = 30). Magnetic Resonance Imaging (MRI) and proton spectroscopy (1H MRS) were performed on a 3T Siemens Tim Trio system. MRS voxels were located in the left/right superior temporal cortices, and spectra acquired with the single voxel Point REsolved Spectroscopy Sequence (PRESS). The spectroscopic data were analyzed with LCModel (Version 6.3.0) software. Results: There were significant differences between groups in terms of glutamate [F = 6.27, p = 0.003], glutamate + glutamine [F = 6.08, p = 0.004], inositol containing compounds (Ino) (F = 9.25, p < 0.001), NAA [F = 7.63, p = 0.001] and creatine + phosphocreatine [F = 11.06, p < 0.001] in the left hemisphere and Ino [F = 5.65, p = 0.005] in the right hemisphere. Post-hoc comparisons showed that the BD-I disorder group had significantly lower metabolite levels in comparison to the BD-II and the HC groups. Limitations: This was a cross-sectional study with a small sample size. In addition, patients were on various psychotropic medications, which may have impacted the results. Conclusions: Neurochemical levels, in the superior temporal cortices, measured with 1H-MRS discriminated between BD-II and BD-I. Although further studies are needed, one may speculate that the superior temporal cortices (particularly left hemispheric) play a critical role, whose pathology may be related to subtyping bipolar disorder. The study was funded by Scientific Research Projects Committee of the Ankara Yıldırım Beyazıt University (Project Code: 803) and NIMH grant to CMM ( MH073998 ) and NIH grant to DO K24 ( MH104449 ). Dr. Phillips acknowledged the support of the Pittsburgh Foundation.

Published
2018

2. Case Reports Presentations

Author

Mustafa Dinçer, Cemil Çelik, Elif Ecem Helvalı, Şahin Bodur, Emine Tuğçe Akçaer, Serdar Süleyman Can, Görkem Karakaş Uğurlu, Sümeyye İslamoğlu, Semra Ulusoy Kaymak, Yasemin Taştorun, Oğuz Peker, Ali Çayköylü, Zehra Ece Soğucak, Aslı Sürer Adanır, Esin Özatalay, Arif Önder, Abdurrahman Erdem Başaran, Ayşen Bingöl, Berhan Akdağ, Murat İlhan Atagün, Yakup Doğan, Öznur Bilaç, Canem Kavurma, Gülseren Taşkıran, Aybike Erdem, Zehra Başar Kocagöz, Adnan Özçetin, Ahmet Ataoğlu, Merve Çavdar Toraman, Özgen Özçelik, Hüseyin Kara, Talya Tomar, Buket Cinemre, Yusuf Tokgöz, Taner Öznur, Abdullah Bolu, Özcan Uzun, İkbal İnanlı, Deniz Altunova, Ali Metehan Çalışkan, İbrahim Eren, Tüba Şerife Elmas, Yasemin Gökçenoğlu, Saliha Çalışır, Ali Baran Tanrıkulu, Şenay Yıldız Bozdoğan, Fatma Şahin, Ceren Çamur, İbrahim Gündoğmuş, Abdulkadir Karagöz, Ayhan Algül, Ebru Doneray, Ipek Percinel Yazici, Kemal Utku Yazici, Aslı Adanır, Yetiş Işıldar, Ebru Sağlam, Ayhan Bilgiç, Betül Akbaş, Çağla Çelikkol, Seher Serez Öztürrk, Hilal Seven, Dudu Demiröz, Seda Özbek, İsmet Esra Çiçek, Fatma Coşkun, Ömer Faruk Akça, Doğa Sevinçok, Çağdaş Öykü Memiş, Burcu Çakaloz, Bilge Çetin İlhan, Tuba Şerife Elmas, Azra Sehure Yaşar, Nafiye Yağlı, Osman Ak, Recep Başaran, Mehmet Murat Balcı, Mehmet Murat Kuloğlu, İbrahim Taş, Sehure Azra Yaşar, Mustafa Çağrı Yıldız, Ebru Çiftçi, Hasan Ali Guler, Ali Kandeger, Dilara Guler, Serhat Turkoglu, Önder Küçük, Ferhat Yaylacı, Handan Özek Erkuran, Betül Kurtses Gürsoy, Seher Serez Öztürk, Berrin Ünal, Gizem Aral, Evrim Özkorumak Karagüzel, Demet Sağlam Aykut, Filiz Civil Arslan, Ezgi Karagöz, Neslihan Emir İnaloğlu, Necati Uzun, Mutlu Muhammed Özbek, Mustafa Tolga Tunagür, Bilge Doğan, Levent Sevinçok, Abdullah Akgün, Kamil Nahit Özmenler, Tayfun Kara, İsmail Akaltun, Ayşe Erdoğan Kaya, Esra Yazıcı, Muhammed Nurullah Sezer, Çağlar Turan, Engin Sert, Yusuf Ezel Yıldırım, Pınar Çetinay Aydın, Sevilay Kunt, Tonguç Demir Berkol, Erman Esnafoglu, Öznur Adıgüzel, Serhat Tunc, Hamit Serdar Basbug, Selçuk Dalyan, Şermin Bilgen Ulgar, Hamza Ayaydın, Sema Bozbey, Merve Yazıcı, Çiğdem Yektaş, Enes Sarıgedik, Mehmet Asoğlu, Betül Uyar Ekmen, Hasan Akçalı, Cuma Taş, Cansu Mercan Işık, Belde Demirci, Seda Aybüke Sarı, Ayla Uzun Çiçek, Ezgi Eynalli, Ozge Metin, Perihan Cam Ray, Aysegul Yolga Tahiroglu, Gonca Gul Celik, Tuğçe Akçaer, Elif Merve Kurt, İbrahim Özkan Göncüoğlu, İsmail Ak, Merve Tsakir Chasan, Lut Tamam, Soner Çakmak, Mehmet Emin Demirkol, Erdem Örnek, Ayşe Sakallı Kani, Volkan Topçuoğlu, Rukiye Çolak Sivri, Nihal Yurteri Çetin, Merve Sertdemir, Emre Ürer, Gökçen İlçioğlu Ekici, Birim Günay Kılıç, Keziban Turgut, Canan Kuygun Karci, Ayse Avci, Azra Yaşar, Sümeyra Elif Kaplan, Hazal Muhsinoglu, Alper Zıblak, Ayşe Nur İnci Kenar, Cantekin Can, Canan Kuygun Karcı, Gamze Kutlu, Çağlar Soykan, Cansu Pınar Şen, Mehmet Fatih Ceylan, Selma Tural Hesapçıoğlu, Özden Şükran Öneri, Abdullah Karataş, Hatice Altun, Umut Karaaslan, Nurdan Kasar, Nilfer Şahin, Damla Balkan, Aslıhan Okan İbiloğlu, Abdullah Atli, Rabia Erdogan, Esra Yazici, Tugba Mutu, Ozlem Akcay Ciner, Ali Savas Cilli, Atila Erol, Esra Porgalı Zayman, Cengiz Darılmaz, İsmail Reyhani, Rıfat Karlıdağ, Kübra Yıldırım, Yunus Emre Dönmez, Serdar Karatoprak, Özlem Özcan, Ali Hakan Öztürk, Özden Şükran Üneri, Perihan Turhan Gürbüz, Mustafa Uğurlu, Özlem Doğan, Tahir Kurtuluş Yoldaş, Nuran Bilgen, Vesile Altınyazar, Muhammed Mutlu Özbek, Ebru Ulu, Esra Demirci, Sevgi Özmen, Ümit Haluk Yeşilkaya, Ozge Sahmelikoglu Onur, Omer Akay, Yasin Hasan Balcioglu, Fatih Oncu, Çiğdem Toklu Yalvaç, Ümit Işık, Erol Erkan, Mehmet Hamdi Örüm, Tezan Bildik, Mahmut Zabit Kara, Helin Yılmaz, Hasan Akın Tahıllıoğlu, Aysun Kalenderoğlu, Oğuzhan Bekir Eğilmez, Murat Eren Özen, Yaşar Kapıcı, Ümit Kılıçoğlu, Murad Atmaca, Gulgaz Karimova, Asiye Arıcı, Feyza Hatice Sevgen, Zehra Alğan, Fadime Dalboy, Mehmet Ak, Faruk Uğuz, Kübra Kılınç, Fatih Hilmi Çetin, Serhat Türkoğlu, Semra Yılmaz, İbrahim İbiloğlu, Mustafa Özkan, Osman Bertizlioğlu, Ece Merve Yazar, Ahmet Özercan, Mehmet Kemal Kuşçu, Muhammet Akbolat, Gazanfer Ekinci, İpek Midi, Fatih Mücahit Harmankaya, Adem Aydın, Neslihan Yazar, Busra Bahar Ataoğlu, Neşe Yorguner Küpeli, Necati Serkut Bulut, Kaan Kora, Cihad Yükselir, Serkan Zincir, Dilşad Yıldız Miniksar, Pelin Çon Bayhan, Faruk Pirinççioğlu, İsmail Karka, Meltem Göbelek, Öznur Akıl, Sümeyra Güngören, Deniz Deniz Özturan, Zeynep Bebek Yılmaz, Derya Deniz Kürekçi, Aykut Özturan, Mihriban Ünay, Hasan Mervan Aytaç, Nazan Aydın, Can Tuncer, Volkan Seneger, Burcu Bakar Kahraman, Selma Hilal Avcı, Hasan Turan Karatepe, Mehmet Arslan, Sıla Çalışkan, Yusuf Çokünlü, Zeynep Yücehan, Seher Serez Öztrük, Hatice Yardım Özayhan, Özlem Karakaya, Gökçen Turan, Burak Elbeyli Ahmet, Safiye Bahar Ölmez, Merve Çavdar, Evrim Aktepe, Pınar Aydoğan Avşar, Yakup Erdoğan, Özlem Beğinoğlu, Rümeysa Yeni Elbay, Hayriye Hızarcıoğlu Gülşen, Arzu Yılmaz, Yasemin İmrek, Mesut Sari, Büşra Pala, Yusuf Öztürk, Güler Göl, Mehmet Akif Cansız, Uğur Savcı, Berna Gündüz Çıtır, Hatice Aksu, Sema Çam Salihoğlu, Nurhak Çağatay Birer, Güler Özkula, Ercan Altınörs, Fatih Baz, Mesut Yıldız, Leyla Bozatlı, Hasan Cem Aykutlu, Işık Görker, Oğuzhan Sapdüzen, Çiçek Hocaoğlu, Alphan Anak, Mesut Yılmaz, Yeliz Doymaz, Ece Ayyıldız, Mehmet Baltacıoğlu, Selvi Ceran Kayıpmaz, Ali Ercan Altınöz, Arzu Oğuz, Sema Çam Salihoglu, Hacer Gizem Gerçek, Mehmet Ayhan Cöngöloğlu, Emre Subas, Selin Alkan, Suat Yalcin, Suleyman Donmezler, Sevilay Umut Kilinc, Burcu Hamurisci Yalcin, Guliz Ozgen, Ahmet Turkcan, Ayse Ceren Kaypak, Nese Yorguner Kupeli, Ali İnaltekin, İbrahim Yağcı, Yüksel Kıvrak, Emine Füsun Akyüz Çim, Leyla Delikanli, Mustafa Tuncturk, Oguz Bilal Karakus, Ali Guven Kılıcoglu, Gul Karacetin, Merve Okuyan, Halil İbrahim İvelik, Burak Okumuş, Rukiye Tekdemir, Memduha Aydın, Nihal Taştekin, Betül Kırşavoğlu, Murat Yalçın, Sibel Ayvaz, Ayşe Gülşah Kırımlı, Ayşegül Taşdelen Kul, Huda Pasli, Mine Ozkan, and Ferda Volkan

Subjects
Child and adolescent, Psychiatry and Mental health, medicine.medical_specialty, Mood disorders, International congress, medicine, Pharmacology (medical), Neurosciences. Biological psychiatry. Neuropsychiatry, Psychopharmacology, Psychiatry, medicine.disease, Psychology, RC321-571
Abstract

10th International Congress on Psychopharmacology & 6th International Symposium on Child and Adolescent Psychopharmacology[Abstract:0103][Mood disorders]A forgotten diagnosis: funeral maniaABSTRACT...

Published
2018

3. 9th International Congress on Psychopharmacology & 5th International Symposium on Child and Adolescent Psychopharmacology

Author

Özge Şahmelikoğlu Onur, Merve Çukurova, Sevda Bağ, Suat Yalçın, Cansu Çakır Şen, Çağatay Karşıdağ, Serdar Süleyman Can, Emine Tuğçe Akçaer, Ayşegül Taşdelen Kul, Mustafa İspir, Osman Bakkal, Ayhan Algül, Servet Ebrinç, Cihad Yükselir, Serkan Zincir, Pelin Öztürk, Bülent Karaahmetoğlu, Özlem Baş, Sema Ulukaya, Çağlar Soykan, Ali Çayköylü, Neslihan Yazar, Zehra Başar Kocagöz, Adnan Özçetin, Safiye Bahar Ölmez, Ahmet Ataoğlu, Yasin Hasan Balcioglu, Tonguc Demir Berkol, Filiz Ekim Cevik, Fatih Oncu, Guliz Ozgen, Dudu Demiröz, Hatice Yardım Özayhan, Hilal Seven, Mustafa Çağrı Yıldız, Recep Başaran, İbrahim Eren, Elif Özlem Canazlar, Levent Sevinçok, Bilge Doğan, Çağdaş Öykü Memiş, Ali Baran Tanrikulu, İkbal İnanli̇, Mustafa Çağri̇ Yi̇ldi̇z, Tuba Şerife Elmas, Ibrahim Eren, Şükrü Alperen Korkmaz, Cansu Pınar Şen, Mehmet Fatih Ceylan, Selma Tural Hesapçıoğlu, Burcu Bakar, Can Tuncer, Rümeysa Yeni Elbay, Aynur Görmez, Yusuf Tokgöz, Abdullah Bolu, Cemil Çelik, Özcan Uzun, Simge Seren Kirlioglu, Pinar Cetinay Aydin, Mustafa Uğurlu, Görkem Karakaş Uğurlu, Zuhal Koç, Nazlı Kapubağlı, Ömer Faruk Tuncer, Gülsen Ünlü, Esra Kabadayı Şahin, Zuhal Koç Apaydın, Semra Ulusoy Kaymak, Oğuz Peker, Bedriye Özkan, Ali Güven Kılıçoğlu, Gül Karaçetin, Zeynep Yücehan, Tuğba Şerife Elmas, Nafiye Yağlı, Bilge Çetin İlhan, Derya Adali Aker, Yiğit Kıvılcım, Mustafa Solmaz, Yeşim Ruhat Kutlu, Bahar Yeşil, Behice Han Almış, Başak Küçük, Cem Cerit, Burcu Sarici, Ayşe Ceren Kaypak, Erensu Baysak, Serhat Ergün, Mesut Yildiz, Aslihan Okan Ibiloglu, Abdullah Atli, Mehmet Asoglu, Mustafa Ozkan, Nursu Çakın Memik, Hatice Ünver, Özlem Yıldız Gündoğdu, Necati Uzun, Ömer Faruk Akça, Gizem Aral, Demet Sağlam Aykut, Özgür Maden, İbrahim Gündoğmuş, Fulya Gok, Seda Kiraz, Arif Cipil, Meliha Zengin Eroglu, Elvan Çiftçi, Zeynep Aslan, Melike Kevser Gül, Neslihan Taştepe, Esra Demirci, Sevgi Özmen, Hicran Doğru, Elif Karayağmurlu, Ali Karayağmurlu, Muhsine Göksu, Leyla Ezgi Tügen, Ayşe Burcu Ayaz, Ayşe Arman, Deniz Altunova, Murat İlhan Atagün, Ekrem Güldaş, Güler Göl, Uğur Savcı, Ali Evren Tufan, Seda Yıldırım Özbek, Süleyman Özbek, Hilal Uygur, Başak Demirel, İ. Esra Çiçek, Hüseyin Kara, Mehmet Murat Balcı, Servet Karaca, Mehmet Murat Kuloğlu, Hasan Mervan Aytaç, Mehmet Can Ger, Aslıhan Okan İbiloğlu, Mehmet Asoğlu, Ayşe Çakır, Ahmet Tiryaki, Gülşah Güçlü Çelme, Mehmet Hamid Boztaş, Fatma Sırmatel, Mucahid Erdogan, Cengiz Dayan, Hayrunisa Dilek Atakli, Gülşen Kartalcı, Ebru Yücel, Şükrü Kartalcı, Meliha Zengin Eroğlu, Arif Çipil, Mecit Çalışkan, Emine Cengiz Çavusoglu, Yusuf Özay Özdemir, Ebru Fındıklı, Berkan Şahin, Koray Karabekiroğlu, Mustafa Kurt, Doğa Sevinçok, Merve Sertdemir, Rukiye Ay, Nevzat Yılmaz, Sevcan Karakoç Demirkaya, Hatice Aksu, Hacer Gizem Gerçek, Gülser Karakoç, Ayşe Ender Altıntoprak, Hakan Coşkunol, Ipek Percinel Yazici, Kemal Utku Yazici, Kevser Altıntaş, Fulya Gök, Ferhat Yaylacı, Handan Özek Erkuran, Murat Eyüboğlu, Diğdem Göverti, Rabia Nazik Yüksel, Alper Bülbül, Makbule Çiğdem Aydemir, Erol Göka, Ilgaz Kınalı, Münevver Yıldırım Hacıoğlu, Burcu Sarıcı, Kemal Sayar, Hatice Doğan, Ömer Akay, Heecheol Kim, Hyunjoo Lee, Abdulkadir Karagöz, Hakan Kullakçı, Yasin Duman, Yusuf Çokünlü, Memduha Aydın, Ali Baran Tanrıkulu, İbrahım Eren, Hande Ayraler Taner, Burcu Akın Sarı, Çiğdem Yektaş, Nuran Demir Samurcu, Saliha Çalışır, Özalp Ekinci, Muhammet Emin Tan, Merve Kalınlı, Murat Kıyançiçek, Meltem Küçükdağ, Hasret Karabulut Gül, Emel Uysal, Filiz Civil Arslan, Evrim Özkorumak Karagüzel, Burak Karakök, Halime Tuna Çak, Pınar Kızılay Çankaya, İlkay Keleş Altun, Eren Abatan, Ali Metehan Çalışkan, Hatice Kübra Çakı, Burak Doğangün, Muhammed Tayyib Kadak, Mehmet Kefeli, Asiye Arıcı, Hatice Altun, Can Acıpayam, Pelin Çon Bayhan, Elif Nurgül Sungur, Ayşe Nur İnci Kenar, Sevde Afife Ersoy, Mehmet Gürkan Gürok, Sevler Yildiz, Tuba Korucu, Denizhan Danaci Keles, Murad Atmaca, Esra Hoşoğlu, Kübra Kılınç, Barış Şen, Erdem Örnek, Cengiz Çelebi, Ayşe Sakallı Kani, Ömer Yanartaş, Zeynep Şenkal, Yıldız Akvardar, Kaan Kora, Ümran Egilmez, Ali Kandeğer, Özkan Güler, Selcen Dogru Kösker, Elif Ates Budak, Zeliha Deveci Karasin, Mehmet Diyaddin Güleken, Mustafa Celik, Hande Yıldırım, Burçin Güler, Baybars Veznedaroğlu, Funda Lale, Halime Tuna Çak Esen, Göknur Haliloğlu, Nuran Ekinci, Gamze Özçürümez Bilgili, Volkan Seneger, Ümit Işık, Gonca Aşut, Elif Tatlıdil Yaylacı, Ömer Asan, Serkan Güneş, Ebru Çiftçi, Sehure Azra Yaşar, İkbal İnanlı, Sencan Sertçelik, Selma Hilal Avci, Alişan Burak Yaşar, Hasan Turan Karatepe, Melike Dönmez, Volkan Topçuoğlu, Ayhan Bilgiç, Volkan Doğru, Abdullah Bozkurt, Tuğba Kalyoncu, Deniz Argüz Çıldır, Can Beşer, Neşe Perdahlı Fiş, Şermin Bilgen Ulgar, Hamza Ayaydın, Hatice Takatak, Hamza Ayaydin, Cansu Çobanoğlu, Mahmut Müjdeci, Yusuf Yasin Gümüş, Betül Akbaş, Feyza Hatice Sevgen, Fatih Öncü, Nilfer Şahin, Damla Balkan, Fatma Coşkun, Savaş Yılmaz, Çağla Çelikkol, Ganime Dilek Emlik, Hüseyin Çaksen, Derya Arslan, Özden Arısoy, Ahmet Şair, Yaşan Bilge Şair, Dilek Sarı, Mustafa Ispir, Ayhan Algul, Vuslat Kara Ölmeztoprak, Esra Porgalı Zayman, Süheyla Ünal, Ali Hakan Öztürk, Başak Karabucak, Ebru Sadriye Çengel Kültür, Tuna Halime Çak Esen, İpek Fatma Özaktaç, Murat Altın, Ayşe Sena Sarıdoğan, Eser Buluş, Sevilay Güneş, Zehra Koyuncu, Rahime Hülya Bingöl, Mine Uzgel, Selahattin Ayas, Yüksel Kıvrak, Yiğit Şahbal, Kübra Kocagöz, Gamze Kutlu, Ali Baz, Mehmet Akif Cansız, Tugba Kalyoncu, Ebru Sağlam, Özlem Önen, Ayşe Kutlu, Ecenur Aydın Aşık, Şermin Yalın Sapmaz, Serpil Erermiş, Şahika Gülen Şişmanlar, İsmail Karka, Fethiye Kilicaslan, Ceren Enüstün Hürmeydan, Ozge Sahmelikoğlu Onur, Didem Nagehan Sarı, Bahar Kılıç, Elif Merve Kurt, İsmail Ak, Ali Emre Şevik, Ayşe Dilara Yalçın, Ümit Tural, Hilmi Yaşar, Münir Karaaslan, Fatih Kizilağaç, Taner Öznur, Ali̇ Baran Tanri̇kulu, Mustafa Çağri Yildiz, İkbal İnanli, Seher Serez Öztürk, Seda Özbek, İsmet Esra Çiçek, Rıfat Karlıdağ, Mustafa Akan, Lara Utku İnce, İsmail Reyhani, Dilek Çağlar Tetik, Ayşe Büyükaslan, Musa Yılanlı, Ender Cesur, Fatma Belger, Bürge Kabukçu Başay, Cansu Pinar Şen, Selma Tural Hesapcioglu, Gülşen Teksin, Nese Yorguner Kupeli, Serhat Ergun, Abdullah Atlı, Öznur Akıl, and Aslıhan Okan İbilioğlu

Subjects
medicine.medical_specialty, Treatment response, Alternative medicine, Neurosciences. Biological psychiatry. Neuropsychiatry, medicine.disease, behavioral disciplines and activities, Comorbidity, Child and adolescent, Psychiatry and Mental health, Schizophrenia, International congress, mental disorders, medicine, Pharmacology (medical), Psychopharmacology, Psychology, Psychiatry, RC321-571, Clinical psychology
Abstract

0009Obsessive-Compulsive Disorder Comorbidity in Children with Schizophrenia: Treatment Response and Clinical CourseABSTRACTObjective: Obsessive-compulsive disorder (OCD) is notably co-mor...

Published
2017

4. Investigating the jumping to conclusion bias in bipolar disorder

Author

Çağlar Soykan, Murat İlhan Atagün, Serdar Süleyman Can, and Şükrü Alperen Korkmaz

Subjects
Adult, Male, Bipolar Disorder, Cognitive Neuroscience, Decision Making, Cognition, Middle Aged, Neuropsychological Tests, medicine.disease_cause, medicine.disease, 030227 psychiatry, 03 medical and health sciences, Psychiatry and Mental health, Young Adult, 0302 clinical medicine, Jumping, Jumping to conclusions, Impulsive Behavior, medicine, Humans, Female, Bipolar disorder, Psychology, 030217 neurology & neurosurgery, Clinical psychology
Abstract

Hemsley and Garety described the "jumping to conclusions bias" in which patients with delusions may reach unreasonable results with insufficient information. In this study patients with bipolar disorder and healthy volunteers were compared in terms of jumping to conclusions bias using the beads in the jar task.37 patients with DSM-5 diagnosis of bipolar disorder and 30 healthy controls were tested with the Beads Task (BT), Tower of London Test (ToL) and Barrat Impulsiveness Scale (BIS).In the BT, the mean score of DtD (draws to decision) and JTC (jumping to conclusions) scores were not statistically different between the two groups. In the ToL test, the duration of the total execution and the total time were significantly longer in the bipolar group than the control group. BIS scores were significantly higher in the bipolar group. YMRS (Young Mania Rating Scale) scores were not correlated with BT.This study is the first clinical study to assess the jumping to conclusions bias in patients with bipolar disorder. No JTC bias was detected in bipolar disorder. Further studies may assess JTC in larger samples to determine the effects of clinical state changes, psychotic symptoms, medication and impulsivity.

Published
2019

5. Intrinsic oscillations of auditory networks in schizophrenia and bipolar disorder

Author

Dost Öngür, Burak Akin, Oktay Algin, Constance M. Moore, Mary L. Phillips, Ali Çayköylü, Murat İlhan Atagün, Elif M. Sikoglu, Serdar Süleyman Can, Semra Ulusoy Kaymak, and Algın, Oktay

Subjects
Psychiatry and Mental health, Bipolar disorder, Schizophrenia, Auditory cortex, medicine, Network, Neurology (clinical), Psychology, medicine.disease, Neuroscience
Abstract

Objective: Several types of evidence have shown that auditory networks are dysfunctional in schizophrenia (Sch) and bipolar disorders (BD). Auditory cortices show abnormalities in hallucinations or during remission. This study aimed to assess resting-state connectivity of auditory cortices in Sch and BD. Method: Patients with BD-1 (n=28), BD-2 (n=21), Sch (n=30), and healthy controls (HC, n=30) were enrolled into the study. A 3 Tesla whole-body magnetic resonance imaging (MRI) system with a 32-channel phase-array head coil was used to acquire the MRI data. T1-weighted anatomical and gradient-echo based Echoplanar Imaging sequences were used. MATLAB and Freesurfer software packages were used for data analyses. Connectivity alterations within the auditory network guided our further seedbased connectivity analysis. Results: The left angular gyrus volume was decreased in Sch and BD-2 groups. The supramarginal gyrus had hyperconnectivity with the medial prefrontal cortices and decreased connectivity with the medial superior temporal gyrus (STG) in the BD-1 and BD-2 groups. The left superior temporal sulcus (STS) had increased connectivity with the bilateral posterior cingulate cortex in BD-1 and BD-2 and increased connectivity with the dorsal prefrontal cortices in the Sch group. The STS had increased connectivity with the medial STG in the BD-1 and Sch groups, whereas connectivity decreased in the BD-2 group. Conclusion: These findings suggest that functional connectivity of resting-state networks are altered in BD and Sch. Auditory network alterations may predispose to dysfunctional auditory information processing. Further studies are needed to determine the relationship between symptoms and auditory network dysfunction.

Published
2019

6. Thiol-disulphide homeostasis in patients with general anxiety disorder and panic disorder

Author

Murat İlhan Atagün, Serdar Süleyman Can, Salim Neselioglu, Gokcen Turan, Esra Kabadayi Sahin, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Şahin, Esra Kabadayı

Subjects
medicine.medical_specialty, business.industry, Panic disorder, medicine.disease, Psychiatry and Mental health, Endocrinology, Generalized Anxiety Disorder, Internal medicine, Panic Disorder, Medicine, In patient, Neurology (clinical), business, Thiol disulphide homeostasis, Thiol-disulphide Homeostasis, Anxiety disorder
Abstract

Objective: The aim of this study was to evaluate the dynamic thiol-disulphide homeostasis as a novel oxidative stress parameter in newly diagnosed and medication-naive general anxiety disorder (GAD) and panic disorder (PD) patients. Method: Medication-naive patients with GAD (n=21) or PD (n=23) and healthy individuals (n=23) were enrolled. Patients were administered a sociodemographic form, Beck Depression Inventory, and Beck Anxiety Inventory. Routine biochemical parameters, native thiol, total thiol, and disulphide parameters were measured in all patients and healthy individuals. Results: The native thiol levels of the GAD and PD groups were found significantly lower than those of the control group (p

Published
2019

7. A Case of Ileus in a Patient with Schizophrenia Under Paliperidone Palmitate Treatment

Author

Esra Kabadayı and Serdar Süleyman Can

Subjects
Constipation, Side effect, Ileus, medicine.medical_treatment, Case Report, 03 medical and health sciences, 0302 clinical medicine, Muscarinic acetylcholine receptor, medicine, 030212 general & internal medicine, Antipsychotic, Biological Psychiatry, Paliperidone Palmitate, Paliperidone palmitate, Complete physical examination, business.industry, medicine.disease, digestive system diseases, Psychiatry and Mental health, Schizophrenia, Anesthesia, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

Constipation is a side effect of antipsychotic drugs that have high affinity for muscarinic cholinergic receptors. In addition, ileus is an important side effect of antipsychotic treatment, with potentially morbid and mortal consequences if early detection fails. In this report, a colonic ileus case is described in a patient with schizophrenia under the treatment of paliperidone palmitate. Consequently, complete physical examination and close screening of side effects are recommended when antipsychotics are prescribed.

Published
2016

8. Agomelatine May Alleviate Valproate Induced Hair Loss

Author

Ali Çayköylü, Murat İlhan Atagün, Serdar Süleyman Can, and Esra Kabadayi Sahin

Subjects
0301 basic medicine, business.industry, Pharmacology, medicine.disease, 03 medical and health sciences, Psychiatry and Mental health, 030104 developmental biology, 0302 clinical medicine, Hair loss, Medicine, Agomelatine, Neurology (clinical), business, 030217 neurology & neurosurgery, medicine.drug
Published
2017

9. Situs Inversus Totalis and Schizophrenia Comorbidity

Author

Semra Ulusoy Kaymak, Murat İlhan Atagün, Serdar Süleyman Can, Ali Çayköylü, Ozkan Unal, Esra Kabadayi Sahin, and Görkem Karakaş Uğurlu

Subjects
Adult, Male, congenital, hereditary, and neonatal diseases and abnormalities, Pediatrics, medicine.medical_specialty, Heart disease, Comorbidity, Lateralization of brain function, mental disorders, otorhinolaryngologic diseases, medicine, Humans, Tetralogy of Fallot, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, General Medicine, Situs Inversus, medicine.disease, Magnetic Resonance Imaging, Psychiatry and Mental health, Situs inversus, Schizophrenia, business, Trisomy
Abstract

The comorbidity of structural or genetic diseases with schizophrenia is seen as an opportunity to understand the formation of schizophrenia. This case report presents a patient with comorbidity of schizophrenia, tetralogy of Fallot (TOF) and total situs inversus. TOF is a cyanotic heart disease, which can be linked to 22q11 deletion and trisomy 21. Situs inversus totalis (SIT) is a congenital condition in which the major visceral organs, including the heart, are positioned in a mirror image from normal conditions. The comorbidity of TOF and SIT is quite rare. In our case report, schizophrenia is added to this rare comorbidity. This case report discussed the comorbidity and probable causal relationships. Furthermore, the research method of how transposition in internal organs is reflected in brain lateralization is also presented.

Published
2017

10. Investigation of Heschl's gyrus and planum temporale in patients with schizophrenia and bipolar disorder: a proton magnetic resonance spectroscopy study

Author

S. Ulusoy-Kaymak, Ali Çayköylü, Dost Öngür, Oktay Algin, G. Karakas-Ugurlu, Constance M. Moore, Mary L. Phillips, Serdar Süleyman Can, Murat İlhan Atagün, Elif M. Sikoglu, and Algın,Oktay

Subjects
Adult, Male, Bipolar Disorder, Bipolar disorder, Proton Magnetic Resonance Spectroscopy, Planum temporale, Glutamine, Auditory cortex, Article, Temporal lobe, Young Adult, Glutamatergic, Magnetic resonance spectroscopy, medicine, Humans, Biological Psychiatry, Auditory Cortex, Analysis of Variance, Aspartic Acid, medicine.diagnostic_test, Magnetic resonance imaging, Middle Aged, Creatine, medicine.disease, Magnetic Resonance Imaging, Temporal Lobe, Psychiatry and Mental health, Heschl's gyrus, Schizophrenia, Female, Glutamate, Superior temporal cortex, Psychology, Neuroscience
Abstract

Background: Superior temporal cortices include brain regions dedicated to auditory processing and several lines of evidence suggest structural and functional abnormalities in both schizophrenia and bipolar disorder within this brain region. However, possible glutamatergic dysfunction within this region has not been investigated in adult patients. Methods: Thirty patients with schizophrenia (38.67 ± 12.46. years of age), 28 euthymic patients with bipolar I disorder (35.32 ± 9.12. years of age), and 30 age-, gender- and education-matched healthy controls were enrolled. Proton magnetic resonance spectroscopy data were acquired using a 3.0. T Siemens MAGNETOM TIM Trio MR system and single voxel Point REsolved Spectroscopy Sequence (PRESS) in order to quantify brain metabolites within the left and right Heschl's gyrus and planum temporale of superior temporal cortices. Results: There were significant abnormalities in glutamate (Glu) (F(2,78) = 8.52, p < 0.0001), N-acetyl aspartate (tNAA) (F(2,81) = 5.73, p = 0.005), creatine (tCr) (F(2,83) = 5.91, p = 0.004) and inositol (Ins) (F(2,82) = 8.49, p < 0.0001) concentrations in the left superior temporal cortex. In general, metabolite levels were lower for bipolar disorder patients when compared to healthy participants. Moreover, patients with bipolar disorder exhibited significantly lower tCr and Ins concentrations when compared to schizophrenia patients. In addition, we have found significant correlations between the superior temporal cortex metabolites and clinical measures. Conclusion: As the left auditory cortices are associated with language and speech, left hemisphere specific abnormalities may have clinical significance. Our findings are suggestive of shared glutamatergic abnormalities in schizophrenia and bipolar disorder. © 2013 Elsevier B.V.

Published
2015

12. P.2.d.046 A DTI-tractography study of the uncinate fasciculus in schizophrenia and bipolar disorder: preliminary results

Author

Ali Çayköylü, Dost Öngür, Mary L. Phillips, G. Karakas-Ugurlu, Constance M. Moore, Murat İlhan Atagün, Serdar Süleyman Can, S. Ulusoy-Kaymak, A. Gonenc, Elif M. Sikoglu, and Oktay Algin

Subjects
Pharmacology, business.industry, Uncinate fasciculus, medicine.disease, Psychiatry and Mental health, Neurology, Schizophrenia, Medicine, Pharmacology (medical), Neurology (clinical), Bipolar disorder, business, Neuroscience, Biological Psychiatry, Dti tractography
Published
2014

13. P.3.b.014 Investigation of Heschl gyrus and planum temporale in patients with schizophrenia and bipolar disorder: a 1H MRS study

Author

Serdar Süleyman Can, Elif M. Sikoglu, Murat İlhan Atagün, Oktay Algin, S. Ulusoy-Kaymak, Ali Çayköylü, Mary L. Phillips, G. Karakas-Ugurlu, Constance M. Moore, and Dost Öngür

Subjects
Pharmacology, medicine.medical_specialty, business.industry, Planum temporale, Audiology, medicine.disease, Psychiatry and Mental health, medicine.anatomical_structure, Neurology, Gyrus, Schizophrenia, Medicine, Pharmacology (medical), In patient, Neurology (clinical), Bipolar disorder, business, Biological Psychiatry, Cognitive psychology
Published
2014

14. Dandy Walker Variant and Bipolar I Disorder with Graphomania

Author

Serdar Süleyman Can, Selcen Çakmak, and Görkem Karakaş Uğurlu

Subjects
medicine.medical_specialty, Bipolar I disorder, Bipolar disorder, Anhedonia, Case Report, Anatomy, Aplasia, medicine.disease, Irritability, Fourth ventricle, Hypoplasia, Psychiatry and Mental health, Cerebellum, medicine, Cerebellar vermis, medicine.symptom, Psychiatry, Psychology, Dandy walker, Biological Psychiatry
Abstract

Cerebellum is known to play an important role in coordination and motor functions. In some resent studies it is also considered to be involved in modulation of mood, cognition and psychiatric disorders. Dandy Walker Malformation is a congenital malformation that is characterized by hypoplasia or aplasia of the cerebellar vermis, cystic dilatation of the fourth ventricle and enlargement of the posterior fossa. When the volume of posterior fossa is normal, the malformation is called Dandy Walker Variant. Case is a 32 year old male with a 12 year history of Bipolar I Disorder presented with manic and depresive symptoms, including dysphoric and depressive affect, anhedonia, suicidal thoughts and behaviours, thoughts of fear about future, overtalkativeness and graphomania, increased energy, irregular sleep, loss of appetite, increased immersion in projects, irritability, agressive behavior, impulsivity. Cranial Magnetic Resonance Imaging was compatible to the morphological features of Dandy Walker Variant.

Published
2014

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