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Carpal Tunnel Syndrome Source:Witt JC, et al. Carpal tunnel syndrome with normal, nerve conduction studies. Muscle Nerve. 2004;29:515-522. How valuable are nerve conduction studies (NCS) in the diagnosis and management [...]

Synopsis: The severity of the neuropathy and the availability of potential treatments, including avoidance of provocative factors, make identification important. Source: Albers JW, et al. Porphyric Neuropathy. Muscle Nerve. 2004;30;410-422. [...]

Source: Blake DJ, Martin-Rendon E. Intermediate filaments and the function of the dystrophin-protein complex. Trends Cardiovasc Med. 2002;12:224-229. CYTOSKELETAL PROTEINS, CRUCIAL TO THE STRUCtural and functional integrity of myocytes, include [...]

ABSTRACT & COMMENTARY Source: Vockley J, Whiteman DMH. Defects of mitochondrial beta-oxidation: A growing group of disorders. Neuromuscul Disord. 2002;12:235-246. FIRST DESCRIBED IN 1973, AT LEAST 22 INBORN DISOR-ders of [...]

Prognostic Predictors in ALS Abstract & Commentary By Michael Rubin, MD, Professor of Clinical Neurology, NewYork Presbyterian Hospital, Cornell Campus. Dr. Rubin reports no financial relationship to this field of [...]

Source: Roberts PF, et al. J Thorac Cardiovasc Surg. 2001; 122:562-568. Is THYMECTOMY BENEFICIAL FOR OCULAR MYASTHEInia gravis (OMG)? Between 1970 and 1998, 61 OMG patients, aged 14-73 years, underwent [...]

Source: Holmes JM, et al. Ophthalmology. 2001;108:1457-1460. NINETY-NINE PATIENTS WITH HEAD TRAUMA FOLlowed by diplopia and sixth nerve palsy, in the absence of oculomotor weakness, were enrolled in this study [...]

Sources: AAEM Quality Assurance Committee. Muscle Nerve. 2001;24:1236-1238; Muscle Nerve. 2001;24:1239-1247. WHAT ELECTRODIAGNOSTIC STUDY Protocol is recommended to confirm the presence of neuromuscular junctionopathy? Searching the Medline English database through [...]

Source: Barendregt PJ, et al. Ann Rheum Dis. 2001;60::876-881. AMONG 39 PATIENTS WITH PRIMARY SJOGREN'S SYNdrome (SS) diagnosed by positive serology (at least 1 positive test among antinuclear, rheumatoid factor, [...]

Source: Lindner A, et al. Neurology. 2001;56:1779-1780. SERUM LACTATE ELEVATION NORMALLY OCCURS with exercise and absence of such elevation is the basis for the ischemic forearm test in the diagnosis [...]

ABSTRACT & COMMENTARY Source: Koike H, et al. Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status. Neurology. 2001;56:1727-1732. ALCOHOLISM IS ONE OF THE MOST COMMON CAUSES of [...]

Sources: Padua L, et al. Multiperspective follow-up of untreated carpal tunnel syndrome: A multicenter study. Neurology. 2001;56:1459-1466. Wong SM, et al. Local vs systemic corticosteroids in the treatment of carpal [...]

Sources: Lawn ND, et al. Anticipating mechanical ventilation in Guillain-Barre syndrome. Arch Neurol. 2001;58:893-898. Hahn AF. The challenge of respiratory dysfunction in Guillain-Barre syndrome. Arch Neurol. 2001;58:871-872. FIRM GUIDELINES EXIST [...]

Source: Gordon PH, Wilbourn AJ. Early electrodiagnostic findings in Guillain-Barre syndrome. Arch Neural. 2001;58:913-917. OBJECTIVE LABORATORY EVIDENCE IS OF SIGNIFICANT benefit in supporting a clinical impression of Guillain-Barre syndrome (GBS). [...]

Source: Grogan PM, Gronseth GS. Neurology. 2001;56:830-836. VARIOUS TREATMENT OPTIONS EXIST FOR BELL'S palsy, some undeniably useful, some unequivocally pointless. Artificial tears, lubricating ophthalmic ointment, and eyelid taping prevent corneal [...]

Source: Lewis SJ, Smith PE. Acta Neurol Scand. 2001;103:320-322. GUIDELINES FOR OSTEOPOROSIS PREVENTION DURING long-term steroid use often go unheeded. Two recommendations are offered: 1) bone density measurements using dual [...]

Source: Gutmann L, Bodensteiner J. Electrodiagnosis of botulism--revisited. J Clin Neuromusc Dis. 2001;2:121-122. BOTULISM MAY BE CORRECTLY DIAGNOSED AT THE bedside in a timely fashion using electrodiagnostic criteria, provided that [...]

Source: Alexiou C, et al. Sudden sensorineural hearing loss: Does application of glucocorticoids make sense? Arch Otolaryngol Head Neck Surg. 2001;127:253-258. SUDDEN SENSORINEURAL HEARING LOSS (SSNHL), though infrequently seen by [...]

Source: Damian MS, et al. Modafinil for excessive daytime sleepiness in myotonic dystrophy. Neurology. 2001;56: 794-796. HYPERSOMNIA IS A PROMINENT FEATURE OF MYOTONic dystrophy (MyD), although, interestingly, it is more [...]

Source: Fanin M, et al. Calpain-3 and dysferlin protein screening in patients with limb-girdle dystrophy and myopathy. Neurology. 2001;56:660-665. AMONG A DATABASE OF APPROXIMATELY 5000 MUScle biopsies performed for childhood [...]

Source: Askmark H, et al. Parkinsonism and neck extensor myopathy: A new syndrome or coincidental findings? Arch Neurol. 2001;58:232-237. AMONG 459 PATIENTS EVALUATED FOR PARKINSONISM between January 1997 and December [...]

ABSTRACTS & COMMENTARY Sources: Chaudhry V, et al. Mycophenolate mofetil: A safe and promising immunosuppressant in neuromuscular diseases. Neurology 2001;56:94-96. Ciafaloni E, et al. Mycophenolate mofetil for myasthenia gravis: An [...]

Source: Van den Berg-Vos RM, et al. Ann Neurol 2000;48:919-926. MULTIFOCAL MOTOR NEUROPATHY WITH CONDUCtion block (MMNCB) is a progressive, peripheral, purely motor, multifocal, demyelinating neuropathy resulting in motor weakness, [...]

Source: Wedekind C, et al. Muscle Nerve 2000;23:1868-1871. INTRAOPERATIVE ELECTROMYOGRAPHIC (EMG) MONItoring of facial muscles may be of benefit during surgery in the cerebellopontine angle. Preoperative testing of the facial [...]

Source: Gabriel CM, et al. Prospective study of the usefulness of sural nerve biopsy. J Neurol Neurosurg Psychiatry 2000;69:442-446. FIFTY CONSECUTIVE PATIENTS UNDERWENT SURAL nerve biopsy to prospectively evaluate its [...]

Source: Kotani N, et al. Intrathecal methylprednisolone for intractable postherpetic neuralgia. N Engl J Med 2000;343:1514-1519. METHYLPREDNISOLONE WAS ADMINISTERED INTRATHECALLY, once-a-week for up to four weeks, in this randomized, blinded, [...]

Source: Galer BS, et al. Lack of efficacy of riluzole in the treatment of peripheral neuropathic pain conditions. Neurology 2000;55:971-975. RILUZOLE DOES LITTLE FOR AMYOTROPHIC LATERAL sclerosis. It appears to [...]

Source: Evans RW, et al. Assessment: Prevention of post lumbar puncture headaches. Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2000;55:909-914. DOES A [...]

Source: Gilron I, et al. A randomized controlled trial of high dose dextromethophan in facial neuralgias. Neurology 2000; 55:964-971. NINETEEN PATIENTS WITH FACIAL NEURALGIA enrolled in a six-week, double-blind, randomized, [...]

ABSTRACT & COMMENTARY Source: Vernino S, et al. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N Engl J Med 2000;343:847-855. IMMUNOPRECIPITATION ASSAYS WITH SOLUBILIZED HUMAN NEUroblastoma acetylcholine receptors [...]

ABSTRACTS & COMMENTARY Sources: Monzani F, et al. Long term interferon-beta-lb therapy for MS: Is routine thyroid assessment always useful? Neurology 2000;55:549-552; Rotondi M, et al. Long-term treatment with interferon-beta [...]

Source: Jenkins PJ, et al. The pathology of median neuropathy in acromegaly. Ann Intern Med 2000;133:197-201. NINE ACROMEGALIC PATIENTS UNDERWENT MAG-netic resonance imaging (MRI) of the carpal tunnel to determine [...]

ABSTRACT & COMMENTARY Source: Goldstein DS, et al. Sympathetic innervation and function in reflex sympathetic dystrophy. Ann Neural 2000; 48:49-59. SYMPATHETIC NEUROCIRCULATORY FUNCTION WAS examined by positron emission tomography ([PET] [...]

ABSTRACT & COMMENTARY Source: Klekar P, et at Distinctive pathologic findings in proximal diabetic neuropathy (diabetic amyotrophy). Neurology 2000;5:83-88. FIFTEEN PATIENTS, EIGHT MEN AND SEVEN WOMEN, ages 49-79 years, with [...]

ABSTRACT & COMMENTARY Source: Vorgerd M, et al. Creatine therapy in myophosphorylase deficiency. Arch Neurol 2000;57:956-963. CREATINE THERAPY BENEFITS IN MITOCHONDRIAL cytopathies (Muscle Nerve 1997;20:1502-1509), as well as various forms [...]

ABSTRACTS & COMMENTARY Sources: Gronseth GS, Barohn RJ. Practice parameter: Thymectomy or autoimmune myasthenia gravis. Report of the quality standards subcommittee of the American Academy of Neurology. Neurology 2000;55: 7-15; [...]

ABSTRACT & COMMENTARY Source: Hirayama K, Tokumaru Y. Cervical dural sac and spinal cord in juvenile muscular atrophy of distal upper extremity. Neurology 2000;54:1922-1926. SEVENTY-THREE JAPANESE PATIENTS--68 MEN AND five [...]

ABSTRACT & COMMENTARY Source: Reinhardt F, et al. Peripheral neuropathy in chronic venous insufficiency. Muscle Nerve 2000;23:883-887. THIRTY CHRONIC VENOUS INSUFFICIENCY (CVI) patients (mean age, 55.1 years) were compared to [...]

Source: Walter MC, et al. Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study. Neurology 2000;54:1848-1850. THIRTY-SIX MUSCULAR DYSTROPHY (MD) PATIENTS, including facioscapulohumeral (n = 12), Becker (n = [...]

ABSTRACT & COMMENTARY Source: Li M, Dalakas MC. The muscle mitogen-activated protein kinase is altered in sporadic inclusion body myositis. Neurology 2000;54:1665-1670. ACCUMULATIONS OF AMYLOID-POSITIVE NON-BRANCHING filaments (termed tubulofilaments) and [...]

ABSTRACT & COMMENTARY Source: Earley CJ, et al. Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology 2000;54:1698-1700. ANXIETAS TIBIARUM (RESTLESS LEGS SYNDROME, RLS), an ultimately [...]

Source: Yuki N, et al. Clinical features and response to treatment in Guillain-Barre syndrome associated with antibodies to GM1b ganglioside. Ann Neural 2000;47;314-321. AMONG 132 GUILLAIN-BARRE SYNDROME (GBs) patients who [...]

Source: Pohl M, et al. Insertion pain in needle electromyography can be reduced by simultaneous finger slapping. Neurology 2000;54:1201-1202. FINGER-SLAPPING THE PATIENT'S SKIN ADJACENT TO, and simutaneously with, needle insertion [...]

Source: Claussen GC, et al. Diagnostic value of nerve and muscle biopsy in suspected vasculitis cases. J Clin Neuromusc Dis 2000;1:117-123. BASED ON A RETROSPECTIVE REVIEW OF 115 NERVE and [...]

Source: Takeuchi H, et al. Immunoglobulin therapy for idiopathic chronic sensory ataxic neuropathy. Neurology 2000; 54:1008-1010. CHRONIC SENSORY ATAXIC (LARGE-DIAMETER FIBER) neuropathy may occur as a consequence of toxic (pyridoxine, [...]

Source: Sanders DB, et al. A randomized trial of 3,4-diaminopyridine in Lambert-Eaton myasthenic syndrome. Neurology 2000;54:603-607. THOUGH YET TO BE FDA APPROVED, 3,4-DIA-minopyridine (DAP) appears to be safe and effective [...]

Source: Beghi E, et al. A randomized controlled trial of recombinant interferon beta-1a in ALS. Neurology 2000; 54;469-474. HOPING THAT INTERFERENCE WITH IMMUNE MECHanisms would have an effect on amyotrophic [...]

Source: Andersson PB, et al. Electrodiagnostic features of hereditary neuropathy with liability to pressure palsies. Neurology 2000;54:40-44. NINE PATIENTS WITH HEREDITARY NEUROPATHY with liability to pressure palsies (HNPP, tomaculous neuropathy) [...]

Source: Nogues MA, Stalberg E. Electrodiagnostic findings in syringomyelia. Muscle Nerve 1999;22:1653-1659. THE ELECTRODIAGNOSTIC DISTINCTION OF SYRINX from motor neuron disease may be impossible. Fibrillation potentials in atrophic arm muscles [...]

Source: Lyu RK, et al. Incidence of irritable electromyography in inflammatory myopathy. J Clin Neuromusc Dis 1999; 1:64-67. NEEDLE ELECTROMYOGRAPHIC (EMG) EXAMINAtion of myositis nearly always reveals a triad of [...]