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Start Over Author "Lobo Vicente J" Topic psychotropic drugs
2 results on '"Lobo Vicente J"'

1. Collaboration of the Joint Research Centre and European Customs Laboratories for the Identification of New Psychoactive Substances.

Author

Guillou C, Reniero F, Lobo Vicente J, Holland M, Kolar K, Chassaigne H, Tirendi S, and Schepers H

Subjects
Biomedical Research trends, Humans, Psychotropic Drugs chemistry, Substance-Related Disorders epidemiology, Substance-Related Disorders prevention & control, Biomedical Research methods, European Union, Intersectoral Collaboration, Psychotropic Drugs analysis
Abstract

Background: The emergence of psychoactive designer drugs has significantly increased over the last few years. Customs officials are responsible for the control of products entering the European Union (EU) market. This control applies to chemicals in general, pharmaceutical products and medicines. Numerous products imported from non-EU countries, often declared as 'bath salts' or 'fertilizers', contain new psychoactive substance (NPS)., Review: These are not necessarily controlled under international law, but may be subject to monitoring in agreement with EU legislation. This situation imposes substantial challenges, for example, for the maintenance of spectral libraries used for their detection by designated laboratories. The chemical identification of new substances, with the use of powerful instrumentation, and the time needed for detailed analysis and interpretation of the results, demands considerable commitment. The EU Joint Research Centre endeavors to provide scientific support to EU Customs laboratories to facilitate rapid identification and characterisation of seized samples. In addition to analysing known NPS, several new chemical entities have also been identified. Frequently, these belong to NPS classes already notified to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) by the European Early- Warning System (EWS)., Conclusion: The aim of this paper is to discuss the implementation of workflow mechanisms that are in place in order to facilitate the monitoring, communication and management of analytical data. The rapid dissemination of this information between control authorities strives to help protect EU citizens against the health risks posed by harmful substances., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)

Published
2018
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2. Systematic analytical characterization of new psychoactive substances: A case study.

Author

Lobo Vicente J, Chassaigne H, Holland MV, Reniero F, Kolář K, Tirendi S, Vandecasteele I, Vinckier I, and Guillou C

Subjects
Belgium, Crime legislation & jurisprudence, Forensic Toxicology, Humans, Magnetic Resonance Spectroscopy, Mass Spectrometry, Psychotropic Drugs analysis, Substance Abuse Detection methods
Abstract

New psychoactive substances (NPS) are synthesized compounds that are not usually covered by European and/or international laws. With a slight alteration in the chemical structure of existing illegal substances registered in the European Union (EU), these NPS circumvent existing controls and are thus referred to as "legal highs". They are becoming increasingly available and can easily be purchased through both the internet and other means (smart shops). Thus, it is essential that the identification of NPS keeps up with this rapidly evolving market. In this case study, the Belgian Customs authorities apprehended a parcel, originating from China, containing two samples, declared as being "white pigments". For routine identification, the Belgian Customs Laboratory first analysed both samples by gas-chromatography mass-spectrometry and Fourier-Transform Infrared spectroscopy. The information obtained by these techniques is essential and can give an indication of the chemical structure of an unknown substance but not the complete identification of its structure. To bridge this gap, scientific and technical support is ensured by the Joint Research Centre (JRC) to the European Commission Directorate General for Taxation and Customs Unions (DG TAXUD) and the Customs Laboratory European Network (CLEN) through an Administrative Arrangement for fast recognition of NPS and identification of unknown chemicals. The samples were sent to the JRC for a complete characterization using advanced techniques and chemoinformatic tools. The aim of this study was also to encourage the development of a science-based policy driven approach on NPS. These samples were fully characterized and identified as 5F-AMB and PX-3 using (1)H and (13)C nuclear magnetic resonance (NMR), high-resolution tandem mass-spectrometry (HR-MS/MS) and Raman spectroscopy. A chemoinformatic platform was used to manage, unify analytical data from multiple techniques and instruments, and combine it with chemical and structural information., (Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.)

Published
2016
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