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The exercise and acute hypoxia PVR findings also demonstrate an increased afterload response to a perturbation among the hypoxic piglets, suggesting that pulmonary vascular abnormalities are unmasked further with cardiopulmonary stress. Keywords: cardiac hypertrophy; cardiopulmonary; hypoxia; right ventricle EN cardiac hypertrophy cardiopulmonary hypoxia right ventricle 2761 2762 2 07/18/23 20230715 NES 230715 Humans born preterm can develop pulmonary vascular disease, in addition to right ventricular (RV) dysfunction later in life, increasing the risk of developing pulmonary hypertension (Goss et al., [2]). It should be noted that only one piglet completed the full 4 weeks in the hypoxia chamber, with each of the piglets being exposed to hypoxia for >=2 weeks, and six of the 10 piglets exposed to hypoxia for >3 weeks. [Extracted from the article]