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Objective: To explore the relationships between serum homocysteine(Hcy), cystatin C(Cys-C)levels and pulmonary function, arterial blood gas analysis indicators and pulmonary arterial systolic pressure in acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients with pulmonary hypertension (PH). Methods: 80 patients with AECOPD combined with pH who were diagnosed and treated in our hospital from December 2017 to December 2019 were selected as the AECOPD combined with pH group. 80 patients with AECOPD without pH were selected as the simple AECOPD group and 50 volunteers who had physical examination in our hospital were selected as the healthy group at the same time. The serum Hcy and Cys-C levels, the ratio of forced expiratory volume to forced vital capacity in the first second (FEV1/FVC), arterial oxygen partial pressure (PaO2), forced expiratory volume in the first second as a percentage of predicted value (FEV1%pred), arterial partial pressure of carbon dioxide (PaCO2), pulmonary artery systolic pressure (PASP) in people who were tested of each group were measured and compared, the correlations of each indicator were analyzed. Results: Serum levels of Hcy, Cys-C and PASP were highest in the AECOPD combined with PH group, followed by the simple AECOPD group, and the lowest in the healthy group (P<0.05). The FEV1%pred, FEV1/FVC were highest in the healthy group, followed by the simple AECOPD group, and the lowest in the AECOPD combined with PH group (P<0.05). Compared with the simple AECOPD group, the PaO2 in the AECOPD combined PH group was significantly decreased, while PaCO2 was significantly increased (P<0.05). According to Pearson correlation analysis, serum Hcy and Cys-C were negatively correlated with FEV1%pred, FEV1/FVC and PaO2 (P<0.05), but positively correlated with PaCO2 and PASP (P<0.05). Conclusion: The abnormal increase of serum Hcy and Cys-C levels is related to the AECOPD patients with PH, which is also exist correlations with the decrease of pulmonary function, the abnormality of arterial blood gas and the abnormal increase of PASP in AECOPD patients with PH. [ABSTRACT FROM AUTHOR]

Objective: To explore the relationships between serum homocysteine(Hcy), cystatin C(Cys-C)levels and pulmonary function, arterial blood gas analysis indicators and pulmonary arterial systolic pressure in acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients with pulmonary hypertension（PH）. Methods: 80 patients with AECOPD combined with pH who were diagnosed and treated in our hospital from December 2017 to December 2019 were selected as the AECOPD combined with pH group. 80 patients with AECOPD without pH were selected as the simple AECOPD group and 50 volunteers who had physical examination in our hospital were selected as the healthy group at the same time. The serum Hcy and Cys-C levels, the ratio of forced expiratory volume to forced vital capacity in the first second (FEV1/FVC), arterial oxygen partial pressure (PaO2), forced expiratory volume in the first second as a percentage of predicted value (FEV1%pred), arterial partial pressure of carbon dioxide (PaCO2), pulmonary artery systolic pressure (PASP) in people who were tested of each group were measured and compared, the correlations of each indicator were analyzed. Results: Serum levels of Hcy, Cys-C and PASP were highest in the AECOPD combined with PH group, followed by the simple AECOPD group, and the lowest in the healthy group (P<0.05). The FEV1%pred, FEV1/FVC were highest in the healthy group, followed by the simple AECOPD group, and the lowest in the AECOPD combined with PH group (P<0.05). Compared with the simple AECOPD group, the PaO2 in the AECOPD combined PH group was significantly decreased, while PaCO2 was significantly increased (P<0.05). According to Pearson correlation analysis, serum Hcy and Cys-C were negatively correlated with FEV1%pred, FEV1/FVC and PaO2 (P<0.05), but positively correlated with PaCO2 and PASP (P<0.05). Conclusion: The abnormal increase of serum Hcy and Cys-C levels is related to the AECOPD patients with PH, which is also exist correlations with the decrease of pulmonary function, the abnormality of arterial blood gas and the abnormal increase of PASP in AECOPD patients with PH. [ABSTRACT FROM AUTHOR]