1. Antimicrobial Activity of Pyrazinamide Coordination Frameworks Synthesized by Mechanochemistry.
- Author
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Quaresma S, Alves PC, Rijo P, Duarte MT, and André V
- Subjects
- Anti-Bacterial Agents pharmacology, Coordination Complexes pharmacology, Drug Stability, Escherichia coli drug effects, Escherichia coli growth & development, Hydrogen Bonding, Microbial Sensitivity Tests, Mycobacterium smegmatis drug effects, Mycobacterium smegmatis growth & development, Organometallic Compounds pharmacology, Pyrazinamide pharmacology, Staphylococcus aureus drug effects, Staphylococcus aureus growth & development, Structure-Activity Relationship, Anti-Bacterial Agents chemical synthesis, Coordination Complexes chemical synthesis, Manganese chemistry, Organometallic Compounds chemical synthesis, Pyrazinamide chemistry, Silver chemistry, Zinc chemistry
- Abstract
The urge for the development of a more efficient antibiotic crystalline forms led us to the disclosure of new antibiotic coordination frameworks of pyrazinamide, a well-known drug used for the treatment of tuberculosis, with some of the novel compounds unravelling improved antimycobacterial activity. Mechanochemistry was the preferred synthetic technique to yield novel compounds, allowing the reproduction of a 1D zinc framework, the synthesis of a novel hydrogen bonding manganese framework, and three new compounds with silver. The structural characterization of the novel forms is presented along with stability studies. The increased antimicrobial activity of the new silver-based frameworks against Escherichia coli , Staphylococcus aureus, and Mycobacterium smegmatis is particularly relevant.
- Published
- 2021
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