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Your search keyword '"Mohammad, Shabbair"' showing total 1 results
Start Over Author "Mohammad, Shabbair" Topic pyrimidines
1 results on '"Mohammad, Shabbair"'

1. Asymmetric Sharpless Dihydroxylation Reaction of Chiral Bishomoallylic Alcohols: Application to the Synthesis of the C1-C10-C5 Fragment of FR225654.

Author

Mohammad, Shabbair, Dhambri, Sabrina, Gori, Didier, Vaxelaire, Carine, Sorin, Geoffroy, Ardisson, Janick, and Lannou, Marie-Isabelle

Subjects
*HYPOGLYCEMIC agents, *CHEMICAL alcohol synthesis, *PYRIMIDINES, *NATURAL products, *LIGANDS (Biochemistry)
Abstract

Toward the synthesis of FR225654, an antidiabetic natural product, the Sharpless asymmetric dihydroxylation of chiral bishomoallylic alcohols, never reported in the literature, was examined. Employing the pyrimidine class of ligands, a high level of matched diastereoselectivity was obtained. An application to the stereoselective synthesis of the C1-C10-C5 fragment of FR225654 was performed. [ABSTRACT FROM AUTHOR]

Published
2013
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