1. Structure, Biosynthesis, and Occurrence of Bacterial Pyrrolizidine Alkaloids.
- Author
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Schimming, Olivia, Challinor, Victoria L., Tobias, Nicholas J., Adihou, Hélène, Grün, Peter, Pöschel, Laura, Richter, Christian, Schwalbe, Harald, and Bode, Helge B.
- Subjects
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CHEMICAL structure , *BIOSYNTHESIS , *PYRROLIZIDINES , *NATURAL products , *NUCLEAR magnetic resonance spectroscopy , *MASS spectrometry , *LIGASES - Abstract
Pyrrolizidine alkaloids (PAs) are widespread plant natural products with potent toxicity and bioactivity. Herein, the identification of bacterial PAs from entomopathogenic bacteria using differential analysis by 2D NMR spectroscopy (DANS) and mass spectrometry is described. Their biosynthesis was elucidated to involve a non-ribosomal peptide synthetase. The occurrence of these biosynthesis gene clusters in Gram-negative and Gram-positive bacteria indicates an important biological function in bacteria. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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