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Conclusion: Our findings indicate that EIF2S1 appears to facilitate the progression of NB by protecting tumor cells from ferroptosis through modulating GPX4 and SLC7A11 expression. Consequently, EIF2S1 may serve as a potential therapeutic target for the management of NB.

We describe the complete mitochondrial genome of the important Polyplacophora species, Acanthochitona rubrolineatus. The mitogenome sequence of A. rubrolineatus is 14,988 bp, and all genes show the typical gene arrangement conforming to the Mollusca consensus. The overall base composition of the genome is T 39.0%, C 12.4%, A 31.2% and G 17.4%. The cytochrome c oxidase subunit I (COI) sequence of A. rubrolineatus and other 111 species from Chitonida were used for phylogenetic analysis by Bayesian inference and maximum-likelihood methods. The results show that A. rubrolineatus, Acanthochitona achates, and Acanthochitona defilippi is sister group to three lineages, and both together as the sister group of A. rubrolineata.

Ischnochiton hakodaensis is one of Polyplacophora species, which plays an important role in the intertidal and subtidal ecosystems. In this study, the complete mitochondrial genome of I. hakodaensis was obtained with 15,139 bp in length, including 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, 2 ribosomal RNA (rRNA) genes. The overall base composition of the genome is 35.93% A, 13.51% G, 37.19% T, 13.38% C. The phylogenetic tree show that I. hakodaensis, Acanthopleura brevispinosa, Acanthopleura granulate, and Liolophura japonica constituted a sister clade along with Tonicia forbesii and Tonicia lamellose.