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Objective We aimed to determine the minimum clinically important difference (MCID) of three different item versions of the Constitution in Chinese Medicine Questionnaire (CCMQ), to facilitate the clinical application of CCMQ. Methods In total, 537 subjects were included in the analysis. All subjects voluntarily completed a comprehensive of traditional Chinese medicine ( TCM) constitution intervention (mood, diet, daily living, exercise, and acupoints). The subjects filled out the 60-item CCMQ and the Short Form Health Questionnaire (SF-36) at baseline and 3 months after the intervention. The result of the 41-item and the 30-item CCMQ were scored according to the result of the 60-item CCMQ. An anchor-based approach and a distribution-based approach were used to estimate the MCID of the three versions of the CCMQ. The anchor of the anchor-based approach was SF-36 item 1, and the analysis method were the mean change method and multiple linear regression. The standardized response mean ( SRM) was used for the distribution-based approach. Results The mean change method and multiple linear regression estimation result were averaged and rounded to whole numbers. The MCID values of the 60-item CCMQ of balanced type, qi-deficiency type, yang-deficiency type, yin-deficiency type, phlegm-dampness type, dampness-heat type, blood-stasis type, qi-depression type, and special diathesis type were 5, -5, -3, -3, -4, -4, -4, -4, and -2, respectively. The MCID values of the 41-item CCMQ were 4, -6, -4, -2, -4, -4, -4, -4, and -2, respectively. The MCID values of the 30-item CCMQ were 5, - 5, - 4, - 3, - 4, - 5, - 4, - 5, and - 2, respectively. The MCID values estimated by the anchor-based approach were higher than those estimated when SRM was 0. 2, except for the special diathesis type. Conclusion The MCID values of three different versions of the CCMQ estimated in this study can reflect the minimum score change of the CCMQ considered important and meaningful by patients, which is helpful for doctors in explaining the effect of TCM constitution intervention or setting intervention targets. [ABSTRACT FROM AUTHOR]

Objective A holistic and comprehensive analysis of traditional Chinese medicine (TCM) constitutions health states was conducted to explore the impact of different concurrently clamped constitution histories on health-related quality of life (HRQOL). Methods　Using the convenient sampling method, the Constitution in Chinese Medicine Questionnaire-41 entry short version, the Chinese verison of SF- 36, and other tools were used to measure the unpaid blood donor population aged 18 to 60 years old, and the fuzzy set qualitative comparative analysis was used to explore configuration of the TCM constitution that affected HRQOL. Results The mean age of the 2 254 study subjects included in the analysis was (30. 72±9. 78) years. The percentage of gentleness constitution was 35. 71%, and 33. 81% had a combination of more than 3 types biased constitutions. Three categories of TCM constitution groupings negatively influenced HRQOL in the physiological domain. First, non-gentleness constitution, qi-deficiency constitution, yang-deficiency constitution, phlegm-wetness constitution, and blood-stasis constitution were the core conditions; second, non-gentleness constitution, qi-deficiency constitution, phlegm-wetness constitution, blood-stasis constitution and special diathesis constitution were the core conditions; and third, all eight biased constitutions were present as core conditions. Three categories of TCM constitution groupings negatively influenced HRQOL in the psychological domain. First, non-gentleness constitution, qideficiency constitution, phlegm-wetness constitution, blood-stasis constitution, and qi-depression constitution were the core conditions; second, non-gentleness constitution, qi-deficiency constitution, yin-deficiency constitution, wetness-heat constitution, and qi-depression constitution were the core conditions; and third, all eight biased constitutions occurred as core conditions. Conclusion　The fuzzyset qualitative comparative analysis method with a configuration perspective revealed the effect of TCM constitution on HRQOL as a multi-component combination of concurrent mechanisms. The diversity of concurrently clamped constitution and the complexity of its relationship with HRQOL were fully analyzed, and this results provide a reference direction for researchers to dig deeper into the intervention pathways of TCM constitution conditioning to enhance quality of life. [ABSTRACT FROM AUTHOR]