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Your search keyword '"Vodnala, Sumathi"' showing total 3 results
Start Over Author "Vodnala, Sumathi" Topic quinazoline
3 results on '"Vodnala, Sumathi"'

2. DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3,2-c]chromene substituted quinazolines and their evaluation towards anticancer activity.

Author

Vodnala, Sumathi, Bhavani, A.K.D., Kamutam, Ramakrishna, Naidu, V.G.M., Promila, null, and Prabhakar, Ch.

Subjects
*QUINAZOLINE, *ANTINEOPLASTIC agents, *CANCER cells, *BREAST cancer, *AROMATIC compounds
Abstract

A facile DABCO promoted one-pot three component synthesis of a new series of C–C linked bis-heterocycle containing dihydropyrano[ c ]chromene as highly fused oxa -heteryl group at C-2 position of quinazoline was developed. Quinazoline-2-carbaldehyde, substituted 4-hydroxycoumarin and ethyl cyanoacetate were used as key components in the Knoevenagel–Michael addition reaction to get the titled compounds. These compounds were screened for anti-cancer activity against the breast cancer cell lines of MDA-MB 231, and MDA-MB 453. [ABSTRACT FROM AUTHOR]

Published
2016
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3. ChemInform Abstract: DABCO-Catalyzed One-Pot Three Component Synthesis of Dihydropyrano[3,2-c]chromene Substituted Quinazolines and Their Evaluation Towards Anticancer Activity.

Author

Vodnala, Sumathi, Bhavani, A. K. D., Kamutam, Ramakrishna, Naidu, V. G. M., Promila, Promila, and Prabhakar, Ch.

Subjects
*PYRIMIDINE derivatives, *PYRIMIDINE synthesis, *QUINAZOLINE, *ANTINEOPLASTIC agents, *SUBSTITUENTS (Chemistry)
Abstract

The synthesized compounds (IV) are screened for their anticancer activity against the breast cancer cell lines MDA-MB 231 and MDA-MB 453. [ABSTRACT FROM AUTHOR]

Published
2016
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