1. A Historical Survey of Key Epidemiological Studies of Ionizing Radiation Exposure.
- Author
-
Little MP, Bazyka D, Gonzalez AB, Brenner AV, Chumak VV, Cullings HM, Daniels RD, French B, Grant E, Hamada N, Hauptmann M, Kendall GM, Laurier D, Lee C, Lee WJ, Linet MS, Mabuchi K, Morton LM, Muirhead CR, Preston DL, Rajaraman P, Richardson DB, Sakata R, Samet JM, Simon SL, Sugiyama H, Wakeford R, and Zablotska LB
- Subjects
- Humans, History, 20th Century, Epidemiologic Studies, History, 21st Century, Occupational Exposure, Radiation, Ionizing, Radiation Exposure adverse effects, Neoplasms, Radiation-Induced epidemiology, Neoplasms, Radiation-Induced etiology
- Abstract
In this article we review the history of key epidemiological studies of populations exposed to ionizing radiation. We highlight historical and recent findings regarding radiation-associated risks for incidence and mortality of cancer and non-cancer outcomes with emphasis on study design and methods of exposure assessment and dose estimation along with brief consideration of sources of bias for a few of the more important studies. We examine the findings from the epidemiological studies of the Japanese atomic bomb survivors, persons exposed to radiation for diagnostic or therapeutic purposes, those exposed to environmental sources including Chornobyl and other reactor accidents, and occupationally exposed cohorts. We also summarize results of pooled studies. These summaries are necessarily brief, but we provide references to more detailed information. We discuss possible future directions of study, to include assessment of susceptible populations, and possible new populations, data sources, study designs and methods of analysis., (© 2024 by Radiation Research Society. All rights of reproduction in any form reserved.)
- Published
- 2024
- Full Text
- View/download PDF