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The experiments on dogs showed that Latranum, a selective blocker of serotonin 5-HT3-receptors, has a moderate capacity to modify emetic reaction caused by dophamin-stimulating action of Apomorphinum. These results, taking in account of our preliminary experimental data obtained by a model of early radiation-induced emetic reactions, show that the high antiemetic effect of Latranum may affect another mechanisms of the initiation of early radiation-inducing vomiting which do not connect immediately with the chemoreceptor trigger zone.

The experiments on dogs exposed to 137Cs gamma quanta at doses of 8 and 20 Gy showed that Latranum, a selective blocker of serotonin 5-HT3-receptors, is a more efficient antiemetic than Dimetpramidum, a D2-dophamin lytic. This is suggested by fewer animals with emetic reaction or by less severe vomiting in case they have any. The results, taking account of earlier data obtained in the experiments on M. fascicularis monkeys, show that the antiemetic effect of the blocker of serotonin 5-HT3-receptors Latranum is not species-specific and equally well manifests itself in animals with different constitutions of the chemoreceptor trigger zone.