1. Radiation exposure: a new risk factor for idiopathic perifoveal telangiectasis.
- Author
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Maberley DA, Yannuzzi LA, Gitter K, Singerman L, Chew E, Freund KB, Noguiera F, Sallas D, Willson R, and Tillocco K
- Subjects
- Aged, Case-Control Studies, Female, Fovea Centralis blood supply, Head radiation effects, Head and Neck Neoplasms radiotherapy, Humans, Male, Neck radiation effects, Occupational Exposure, Radiation Injuries pathology, Retinal Vessels pathology, Retrospective Studies, Risk Factors, Sinusitis radiotherapy, Skin Diseases radiotherapy, Surveys and Questionnaires, Telangiectasis pathology, Fovea Centralis radiation effects, Radiation Injuries etiology, Radiotherapy adverse effects, Retinal Vessels radiation effects, Telangiectasis etiology
- Abstract
Objective: To examine the association between previous radiation exposure and idiopathic perifoveal telangiectasis (IPT)., Design: A multicentered, individually matched, case-control study design was used. PARTICIPANTS/CONTROLS: Sixty-five case subjects were matched with 175 control subjects. Individuals with unequivocal evidence of angiographically confirmed IPT were included as cases. Control subjects were matched for center, age, and gender., Main Outcome Measure: The main exposures of interest were a history of therapeutic head or neck irradiation and environmental radiation exposure., Methods: A standardized questionnaire was administered to case and control subjects. Data were collected for the main exposures of interest as well as pertinent covariates. Conditional logistic regression was used to evaluate therapeutic and environmental radiation as risks for IPT., Results: On univariate analysis, head or neck irradiation was associated with IPT (odds ratios [OR] = 4.15, 95% confidence interval [CI] = 1.30-13.24). While controlling for diabetes and family history of diabetes, IPT was found to be associated with both head or neck irradiation (OR = 4.06, 95% CI = 1.20-13.76) and with environmental irradiation (OR = 6.73, 95% CI = 1.06-42.74)., Conclusions: This study presents a previously unreported association between prior radiation exposure and IPT.
- Published
- 1999
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