1. Adaptive Radiation Therapy (ART) Strategies and Technical Considerations: A State of the ART Review From NRG Oncology
- Author
-
Adam D. Yock, Minsong Cao, Jeffrey R. Olsen, Carri K Glide-Hurst, Anthony Doemer, Farzan Siddiqui, William Parker, Stanley H Benedict, Yi Rong, Ying Xiao, Jason W. Sohn, X. Allen Li, Evan Wuthrick, Percy Lee, Beth Erickson, and Amar U. Kishan
- Subjects
Oncology ,Organs at Risk ,Cancer Research ,medicine.medical_specialty ,Quality Assurance, Health Care ,Process (engineering) ,As is ,Brachytherapy ,Radiotherapy Planning ,Clinical Trials and Supportive Activities ,Clinical Sciences ,Oncology and Carcinogenesis ,Article ,030218 nuclear medicine & medical imaging ,Workflow ,03 medical and health sciences ,0302 clinical medicine ,Computer-Assisted ,Clinical Research ,Internal medicine ,Health care ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Oncology & Carcinogenesis ,Radiation treatment planning ,Tomography ,Cancer ,Protocol (science) ,Clinical Trials as Topic ,Radiation ,Radiotherapy ,business.industry ,Radiotherapy Planning, Computer-Assisted ,Radiotherapy Dosage ,X-Ray Computed ,Clinical trial ,Health Care ,Other Physical Sciences ,Image-Guided ,030220 oncology & carcinogenesis ,business ,Tomography, X-Ray Computed ,Quality Assurance ,Quality assurance ,Radiotherapy, Image-Guided - Abstract
The integration of adaptive radiation therapy (ART), or modifying the treatment plan during the treatment course, is becoming more widely available in clinical practice. ART offers strong potential for minimizing treatment-related toxicity while escalating or de-escalating target doses based on the dose to organs at risk. Yet, ART workflows add complexity into the radiation therapy planning and delivery process that may introduce additional uncertainties. This work sought to review presently available ART workflows as well as technological considerations such as image quality, deformable image registration, and dose accumulation. Quality assurance considerations for ART components and minimum recommendations are described. Personnel and workflow efficiency recommendations are provided as well as a summary of currently available clinical evidence supporting the implementation of ART. Finally, to guide future clinical trial protocols, an example ART physician directive and a physics template following standard NRG Oncology protocol is provided.
- Published
- 2021