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Your search keyword '"Purushothaman, Sivaji"' showing total 3 results
Start Over Author "Purushothaman, Sivaji" Topic radioactive ion beams
3 results on '"Purushothaman, Sivaji"'

1. Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI

Author

Boscolo, Daria, Kostyleva, Daria, Safari, Mohammad Javad, Anagnostatou, Vasiliki, Äystö, Juha, Bagchi, Soumya, Binder, Tim, Dedes, Georgios, Dendooven, Peter, Dickel, Timo, Drozd, Vasyl, Franczack, Bernhard, Geissel, Hans, Gianoli, Chiara, Graeff, Christian, Grahn, Tuomas, Greiner, Florian, Haettner, Emma, Haghani, Roghieh, Harakeh, Muhsin N., Horst, Felix, Hornung, Christine, Hucka, Jan-Paul, Kalantar-Nayestanaki, Nasser, Kazantseva, Erika, Kindler, Birgit, Knöbel, Ronja, Kuzminchuk-Feuerstein, Natalia, Lommel, Bettina, Mukha, Ivan, Nociforo, Chiara, Ishikawa, Shunki, Lovatti, Giulio, Nitta, Munetaka, Ozoemelam, Ikechi, Pietri, Stephane, Plass, Wolfgang R., Prochazka, Andrej, Purushothaman, Sivaji, Reidel, Claire-Anne, Roesch, Heidi, Schirru, Fabio, Schuy, Christoph, Sokol, Olga, Steinsberger, Timo, Tanaka, Yoshiki K., Tanihata, Isao, Thirolf, Peter, Tinganelli, Walter, Voss, Bernd, Weber, Uli, Weick, Helmut, Winfield, John S., Winkler, Martin, Zhao, Jianwei, Scheidenberger, Christoph, Parodi, Katia, Durante, Marco, Boscolo, Daria, Kostyleva, Daria, Safari, Mohammad Javad, Anagnostatou, Vasiliki, Äystö, Juha, Bagchi, Soumya, Binder, Tim, Dedes, Georgio, Dendooven, Peter, Dickel, Timo, Drozd, Vasyl, Franczack, Bernhard, Geissel, Han, Gianoli, Chiara, Graeff, Christian, Grahn, Tuoma, Greiner, Florian, Haettner, Emma, Haghani, Roghieh, Harakeh, Muhsin N, Horst, Felix, Hornung, Christine, Hucka, Jan-Paul, Kalantar-Nayestanaki, Nasser, Kazantseva, Erika, Kindler, Birgit, Knöbel, Ronja, Kuzminchuk-Feuerstein, Natalia, Lommel, Bettina, Mukha, Ivan, Nociforo, Chiara, Ishikawa, Shunki, Lovatti, Giulio, Nitta, Munetaka, Ozoemelam, Ikechi, Pietri, Stephane, Plaß, Wolfgang R, Prochazka, Andrej, Purushothaman, Sivaji, Reidel, Claire-Anne, Roesch, Heidi, Schirru, Fabio, Schuy, Christoph, Sokol, Olga, Steinsberger, Timo, Tanaka, Yoshiki K, Tanihata, Isao, Thirolf, Peter, Tinganelli, Walter, Voss, Bernd, Weber, Uli, Weick, Helmut, Winfield, John S, Winkler, Martin, Zhao, Jianwei, Scheidenberger, Christoph, Parodi, Katia, Durante, Marco, and Nuclear Energy

Subjects
NUCLEI, Physics::Instrumentation and Detectors, Physics::Medical Physics, PERFORMANCE, PROTON, MOVING TARGETS, SIMULATIONS, carbon ions, PET, Oncology, particle therapy, ADENOID CYSTIC CARCINOMA, RADIATION-THERAPY, IMPLEMENTATION, Physics::Accelerator Physics, ddc:610, Nuclear Experiment, radioactive ion beams, SYSTEM, oxygen ion, RADIOTHERAPY, carbon ion, Original Research, oxygen ions
Abstract

Several techniques are under development for image-guidance in particle therapy. Positron (beta(+)) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by beta(+)-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using beta(+)-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy.

Published
2021

2. Precision of the PET activity range during irradiation with 10 C, 11 C, and 12 C beams

Author

Kostyleva, D., Purushothaman, Sivaji, Dendooven, P., Haettner, Emma, Geissel, H., Ozoemelam, I., Schuy, C., Weber, U., Boscolo, Daria, Dickel, T., Drozd, V., Graeff, C., Franczak, B., Hornung, C., Horst, F., Kazantseva, E., Kuzminchuk-Feuerstein, N., Mukha, I., Nociforo, C., Pietri, S., Reidel, C. A., Roesch, H., Tanaka, Y. K., Weick, H., Zhao, J., Durante, Marco, Parodi, K., and Scheidenberger, C.

Subjects
carbon ions, PET, Radiological and Ultrasound Technology, particle therapy, Radiology, Nuclear Medicine and imaging, ddc:530, radioactive ion beams, range verification
Abstract

Physics in medicine and biology 68(1), 015003 (2023). doi:10.1088/1361-6560/aca5e8, Published by IOP Publ., Bristol

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3. Depth dose measurements in water for 11C and 10C beams with therapy relevant energies.

Author

Boscolo, Daria, Kostyleva, Daria, Schuy, Christoph, Weber, Uli, Haettner, Emma, Purushothaman, Sivaji, Dendooven, Peter, Dickel, Timo, Drozd, Vasyl, Franczack, Bernhard, Geissel, Hans, Hornung, Christine, Horst, Felix, Kazantseva, Erika, Kuzminchuk-Feuerstein, Natalia, Lovatti, Giulio, Mukha, Ivan, Nociforo, Chiara, Pietri, Stephane, and Pinto, Marco

Subjects
*PLASMA beam injection heating, *BATHYMETRY, *ION beams, *MONTE Carlo method, *ION bombardment, *POSITRON emission tomography, *RADIOACTIVE nuclear beams
Abstract

Owing to the favorable depth-dose distribution and the radiobiological properties of heavy ion radiation, ion beam therapy shows an improved success/toxicity ratio compared to conventional radiotherapy. The sharp dose gradients and very high doses in the Bragg peak region, which represent the larger physical advantage of ion beam therapy, make it also extremely sensitive to range uncertainties. The use of β + -radioactive ion beams would be ideal for simultaneous treatment and accurate online range monitoring through PET imaging. Since all the unfragmented primary ions are potentially contributing to the PET signal, these beams offer an improved image quality while preserving the physical and radiobiological advantages of the stable counterparts. The challenging production of radioactive ion beams and the difficulties in reaching high intensities, have discouraged their clinical application. In this context, the project Biomedical Applications of Radioactive ion Beams (BARB) started at GSI (Helmholtzzentrum für Schwerionenforschung GmbH) with the main goal to assess the technical feasibility and investigate possible advantages of radioactive ion beams on the pre-clinical level. During the first experimental campaign 11C and 10C beams were produced and isotopically separated with the FRagment Separator (FRS) at GSI. The β + -radioactive ion beams were produced with a beam purity of 99% for all the beam investigated (except one case where it was 94%) and intensities potentially sufficient to treat a small animal tumors within few minutes of irradiation time, ∼ 1 0 6 particle per spill for the 10C and ∼ 1 0 7 particle per spill for the 11C beam, respectively. The impact of different ion optical parameters on the depth dose distribution was studied with a precision water column system. In this work, the measured depth dose distributions are presented together with results from Monte Carlo simulations using the FLUKA software. [ABSTRACT FROM AUTHOR]

Published
2022
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