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OBJECTIVE: The objective of this article is to present imaging findings in tuberous sclerosis complex (TSC), which will eventually help in imaging based diagnosis. STUDY DESIGN: Retrospective study PLACE AND DURATION OF STUDY: Radiology Department, Shifa International Hospital, from 2010 to 2021. METHODOLOGY: Total of 20 patients were selected from the radiology database retrospectively from 2010 to 2021. These patients were diagnosed with Tuberous Sclerosis by radiology department and their scans were performed and reviewed at CT and MRI machines of Shifa International Hospital. CT scan was performed on Toshiba 640 slices, Siemens 128 slices and Siemens 16 slices, and MRI was performed on Siemens 3 tesla, Toshiba-titan 1.5 tesla and Hitachi 0.4 tesla. The literature review was also done to identify different organ system involvement of this disease. RESULT: Different organ system involvement by this disease and imaging features of them are reported. CONCLUSION: TSC has wide range of radiological imaging findings. Recognition of various organ manifestations on imaging is necessary for making the accurate diagnosis and is helpful in the treatment plan. [ABSTRACT FROM AUTHOR]