1. Detection of Active Inflammation Status Around Ventricular Aneurysms in Patients With Cardiac Sarcoidosis.
- Author
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Nanno T, Kobayashi S, Yoshitomi R, Fujii S, Kajii T, Kohno M, Ishiguchi H, Okuda S, Okada M, Suga K, and Yano M
- Subjects
- Adrenal Cortex Hormones therapeutic use, Adult, Aged, Aged, 80 and over, Cardiomyopathies drug therapy, Female, Heart Aneurysm drug therapy, Humans, Male, Middle Aged, Myocarditis drug therapy, Predictive Value of Tests, Prospective Studies, Sarcoidosis drug therapy, Treatment Outcome, Cardiomyopathies diagnostic imaging, Fluorodeoxyglucose F18 administration & dosage, Heart Aneurysm diagnostic imaging, Myocarditis diagnostic imaging, Positron Emission Tomography Computed Tomography, Radiopharmaceuticals administration & dosage, Sarcoidosis diagnostic imaging
- Abstract
Background: Little is known about the pattern of isotope accumulation in the heart on
18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography in patients with cardiac sarcoidosis (CS) complicated by ventricular aneurysm (VA).Methods and Results:We prospectively enrolled 82 consecutive patients with CS; 54 patients with active CS (presence of abnormal18 F-FDG accumulation in the heart) were subdivided into VA (n=17) and non-VA groups (n=37). Strong18 F-FDG accumulation surrounding the VA and its disappearance in the VA center was observed in all patients with VA, probably because of scar formation at the VA. Peak standardized uptake value was higher around the VA than in the VA center (5.1±2.1 vs. 2.2±0.6, P=0.0003) and the VA center had no18 F-FDG accumulation (VA center: 2.2±0.6 vs. control area: 2.1±0.6, P=0.37). On the other hand, in non-VA patients with LV wall thinning (n=28),18 F-FDG accumulation was significantly high, even in the area of LV wall thinning (LV wall thinning area: 3.1±0.8 vs. control area: 2.0±0.6, P=0.00002)., Conclusions: A pattern of strong18 F-FDG accumulation surrounding the VA and its disappearance in the VA center might be characteristic in patients with CS complicated by VA. Careful attention to FDG uptake would further elucidate CS pathophysiology and aid in the early treatment of VA.- Published
- 2019
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