1. Treinamento físico reverte alterações no diâmetro de mitocôndrias hepáticas de ratos diabéticos induzidos pela Aloxana.
- Author
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Keine Kuga, Gabriel, Calais Gaspar, Rafael, Rosetto Muñoz, Vitor, Branco Ramos Nakandakari, Susana Castelo, Breda, Leonardo, Marina Sandoval, Bruna, Henrique Caetano, Flávio, Curiacos de Almeida Leme, José Alexandre, Rodrigo Pauli, José, and José Gomes, Ricardo
- Abstract
Objective: To investigate the effects of physical training on metabolic and morphological parameters of diabetic rats. Methods: Wistar rats were randomized into four groups: sedentary control, trained control, sedentary diabetic and trained diabetic. Diabetes mellitus was induced by Alloxan (35mg/kg) administration for sedentary diabetic and Trained Diabetic Groups. The exercise protocol consisted of swimming with a load of 2.5% of body weight for 60 minutes per day (5 days per week) for the trained control and Trained Diabetic Groups, during 6 weeks. At the end of the experiment, the rats were sacrificed and blood was collected for determinations of serum glucose, insulin, albumin and total protein. Liver samples were extracted for measurements of glycogen, protein, DNA and mitochondrial diameter determination. Results: The sedentary diabetic animals presented decreased body weight, blood insulin, and hepatic glycogen, as well as increased glycemia and mitochondrial diameter. The physical training protocol in diabetic animals was efficient to recovery body weight and liver glycogen, and to decrease the hepatic mitochondrial diameter. Conclusion: Physical training ameliorated hepatic metabolism and promoted important morphologic adaptations as mitochondrial diameter in liver of the diabetic rats. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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