1. Comparison of three rat strains for development of radiation-induced lung injury after hemithoracic irradiation.
- Author
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van Eerde MR, Kampinga HH, Szabo BG, and Vujaskovic Z
- Subjects
- Animals, Disease Susceptibility, Lung diagnostic imaging, Lung Diseases diagnostic imaging, Lung Diseases physiopathology, Pulmonary Circulation radiation effects, Radiation Dosage, Radiation Tolerance, Radionuclide Imaging, Rats, Rats, Inbred F344, Rats, Sprague-Dawley, Rats, Wistar, Respiration radiation effects, Disease Models, Animal, Lung radiation effects, Lung Diseases etiology, Radiation Injuries diagnostic imaging, Radiation Injuries physiopathology, Rats, Inbred Strains
- Abstract
The purpose of this study is to define differences in radiation sensitivity among rat strains using breathing frequency and lung perfusion as end points of radiation-induced lung injury. The results have confirmed previous findings in mice showing that under stringently controlled iso-dose/volume irradiation conditions, substantial differences can be found in susceptibility to functional lung damage after radiation.
- Published
- 2001
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