1. Intracranial CAR-T cell delivery in glioblastoma patients.
- Author
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Vaughn-Beaucaire P, Choi MJ, Liang O, and Lawler SE
- Subjects
- Humans, T-Lymphocytes immunology, T-Lymphocytes metabolism, Glioblastoma therapy, Glioblastoma immunology, Glioblastoma pathology, Immunotherapy, Adoptive methods, Immunotherapy, Adoptive adverse effects, Receptors, Chimeric Antigen immunology, Receptors, Chimeric Antigen metabolism, Brain Neoplasms therapy, Brain Neoplasms immunology, Brain Neoplasms pathology
- Abstract
Chimeric antigen receptor (CAR)-T cell therapy is emerging as a promising approach for improving outcomes in high-grade glioma. Here, we highlight three recent studies that reported safety and feasibility of intracranial CAR-T cell administration in patients with glioblastoma (GBM) as well as preliminary evidence of potential responses, supporting further investigations of this approach., Competing Interests: Declaration of interests No interests are declared., (Published by Elsevier Inc.)
- Published
- 2024
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