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The aim of the study was to analyze the expression of certain proteins (p53, Bcl-2) and to find correlations between the status of these markers and clinicopathological parameters, and prognosis in patients with rectal cancer. This study included 50 patients diagnosed with rectal cancer (stage I-III AJCC staging system 8th edition) who underwent preoperative oncological treatment and then rectal resection procedures in Clinical Emergency Hospital Bucharest in the period 01.01.2016 – 31.12.2017. p53 and Bcl-2 expression was examined using immunohistochemistry from pathological specimens obtained after surgery in the Clinical Emergency Hospital Bucharest pathology laboratory. We observed significant associations between Bcl2 and age or extramural vascular invasion, and between p53 and hemoglobin value at admission. The univariate analysis of disease free survival (DFS) showed an important link between the presence of p53 and a poor prognosis, and the multivariate one demonstrated that the best outcome was registered for the patients with p53 negative/Bcl-2 positive phenotype. In conclusion, we believe that immunohistochemical detection of these proteins is an important tool in determining the prognosis of the patients with rectal cancer.

The objective of this paper was to find correlations between clinico-pathological parameters and survival and tumor recurrence indices with the purpose of improving treatment results and asses better the prognosis of the patients with rectal cancer. The study included 69 patients with rectal cancer in stages I-III according to the AJCC classification (8th edition), who didn’t undergo neoadjuvant treatment and were operated (curative surgery) in the General Department of the Emergency Clinical Hospital Bucharest in a period of 2 years, 01.01.2016 – 31.12.2017. Our statistical analysis showed significant correlations between the quality of the mesorectum and tumor localization, type of surgery or overall survival. Also, we registered important associations between the N stage from TNM classification and tumor grading or lymphovascular invasion. In conclusion, we can say that these correlations observed in our study between clinico-pathological and prognostic parameters in patients with rectal cancer are useful in the treatment and for determining the outcome of these patients.