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With the rise of deep learning technology, due to the superior performance of the deep neural network, its application in the digital economy has attracted extensive attention of scholars. Since the beginning of the 21st century, my country's digital economy has developed rapidly, and its universalization and other characteristics have created favorable conditions for the optimal allocation of resources in underdeveloped regions and the exertion of comparative advantages. The digital economy will play a key role in poverty alleviation, promoting coordinated regional development, narrowing regional gaps, and improving the spatial layout of my country's reform and opening up. This paper studies the factors that the digital economy based on deep neural networks has on regional economic growth. Simulation experiment conclusions are as follows: (1) the digital economy of Guizhou, Beijing, Chongqing, Anhui, and Tibet is growing rapidly. The central and western regions are in a period of rapid growth. For the gap between major industrial provinces, the coefficient of variation reached about 1 before 2013, then it declined rapidly, and slowed down, and steadily declined after 2019, indicating that the gap in the digital economy in various regions is narrowing in general. (2) From the national level, the digital economy index coefficient is 1.24, that is, for every 1% increase in digital economy investment, GDP will increase by about 0.24%. The labor force increased by 1% and the GDP increased by about 0.22%. This promotion effect is also very obvious. (3) Judging from the above data, the western region urgently needs to promote the construction of the digital economy and introduce high-tech digital economy talents. The talent effect in the Midwest has a significant effect on GDP. (4) From the perspective of the whole country and other regions, the parameter coefficients and signs have not changed significantly, so the original model is robust, and so the conclusion is desirable. [ABSTRACT FROM AUTHOR]