15 results on '"Pomeroy, Valerie M."'
Search Results
2. The potential for utilizing the 'mirror neurone system' to enhance recovery of the severely affected upper limb early after stroke: a review and hypothesis
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Pomeroy, Valerie M., Clark, Christopher A., Miller, J. Simon G., Baron, Jean-Claude, Markus, Hugh S., and Tallis, Raymond C.
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Stroke (Disease) ,Therapeutics, Physiological ,Rehabilitation ,Physical therapy ,Psychology and mental health - Abstract
Recovery of upper limb movement control after stroke might be enhanced by repetitive goal-directed functional activities. Providing such activity is challenging in the presence of severe paresis. A possible new [...]
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- 2005
3. Sensory Stimulation of the Foot and Ankle Early Post-stroke: A Pilot and Feasibility Study.
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Aries, Alison M., Pomeroy, Valerie M., Sim, Julius, Read, Susan, and Hunter, Susan M.
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SENSORY stimulation ,STROKE ,FEASIBILITY studies ,PILOT projects ,ANKLE ,WALKING speed ,VERTEBRAL artery - Abstract
Background: Somatosensory stimulation of the lower extremity could improve motor recovery and walking post-stroke. This pilot study investigated the feasibility of a subsequent randomized controlled trial (RCT) to determine whether task-specific gait training is more effective following either (a) intensive hands-on somatosensory stimulation or (b) wearing textured insoles. Objectives: Determine recruitment and attrition rates, adherence to intervention, acceptability and viability of interventions and outcome measures, and estimate variance of outcome data to inform sample size for a subsequent RCT. Methods: Design: randomized, single-blinded, mixed-methods pilot study. Setting: In-patient rehabilitation ward and community. Participants: n = 34, 18+years, 42–112 days following anterior or posterior circulation stroke, able to follow simple commands, able to walk independently pre-stroke, and providing informed consent. Intervention: Twenty 30-min sessions of task-specific gait training (TSGT) (delivered over 6 weeks) in addition to either: (a) 30–60 min mobilization and tactile stimulation (MTS); or (b) unlimited textured insole (TI) wearing. Outcomes: Ankle range of movement (electrogoniometer), touch-pressure sensory thresholds (Semmes Weinstein Monofilaments), motor impairment (Lower Extremity Motricity Index), walking ability and speed (Functional Ambulation Category, 5-m walk test, pressure insoles) and function (modified Rivermead Mobility Index), measured before randomization, post-intervention, and 1-month thereafter (follow-up). Adherence to allocated intervention and actual dose delivered (fidelity) were documented in case report forms and daily diaries. Focus groups further explored acceptability of interventions and study experience. Analysis: Recruitment, attrition, and dose adherence rates were calculated as percentages of possible totals. Thematic analysis of daily diaries and focus group data was undertaken. Standard deviations of outcome measures were calculated and used to inform a sample size calculation. Results: Recruitment, attrition, and adherence rates were 48.57, 5.88, and 96.88%, respectively. Focus groups, daily-diaries and case report forms indicated acceptability of interventions and outcome measures to participants. The 5-m walk was selected as primary outcome measure for a future trial [mean (SD) at end of intervention: 16.86 (11.24) MTS group and 21.56 (13.57) TI group]; sample size calculation indicated 60 participants are required per group. Conclusion: Recruitment, attrition and adherence rates and acceptability of interventions and outcomes justify a subsequent powered RCT of MTS+TSGT compared with TI+TSGT. [ABSTRACT FROM AUTHOR]
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- 2021
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4. A Randomized Controlled Evaluation of the Efficacy of an Ankle-Foot Cast on Walking Recovery Early After Stroke
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Pomeroy, Valerie M., Rowe, Philip, Clark, Allan, Walker, Andrew, Kerr, Andrew, Chandler, Elizabeth, Barber, Mark, and Baron, Jean-Claude
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walking ,orthotics ,physical therapy ,stroke ,health care economics and organizations ,Clinical Research Articles ,rehabilitation - Abstract
Background. Timely provision of an ankle-foot orthosis (AFO) orthotist customized for individuals early after stroke can be problematic. Objective. To evaluate the efficacy of a therapist-made AFO (SWIFT Cast) for walking recovery. Methods. This was a randomized controlled, observer-blind trial. Participants (n = 105) were recruited 3 to 42 days poststroke. All received conventional physical therapy (CPT) that included use of “off-the-shelf” and orthotist-made AFOs. People allocated to the experimental group also received a SWIFT Cast for up to 6 weeks. Measures were undertaken before randomization, 6 weeks thereafter (outcome), and at 6 months after stroke (follow-up). The primary measure was walking speed. Clinical efficacy evaluation used analysis of covariance. Results. Use of a SWIFT Cast during CPT sessions was significantly higher (P < .001) for the SWIFT Cast (55%) than the CPT group (3%). The CPT group used an AFO in 26% of CPT sessions, compared with 11% for the SWIFT Cast group (P = .005). At outcome, walking speed was 0.42 (standard deviation [SD] = 0.37) m/s for the CPT group and 0.32 (SD = 0.34) m/s for the SWIFT Cast group. Follow-up walking speed was 0.53 (SD = 0.38) m/s for the CPT group and 0.43 (0.34) m/s for the SWIFT Cast group. Differences, after accounting for minimization factors, were insignificant at outcome (P = .345) and follow-up (P = .360). Conclusion and implications. SWIFT Cast did not enhance the benefit of CPT, but the control group had greater use of another AFO. However, SWIFT Cast remains a clinical option because it is low cost and custom-made by therapists who can readily adapt it during the rehabilitation period.
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- 2016
5. Identification of neuromuscular targets for restoration of walking ability after stroke: Precursor to precision rehabilitation.
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Hancock, Nicola J., Shepstone, Lee, Rowe, Philip, and Pomeroy, Valerie M.
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SKELETAL muscle physiology ,CONFIDENCE intervals ,CONVALESCENCE ,STATISTICAL correlation ,ELECTROMYOGRAPHY ,KINEMATICS ,LONGITUDINAL method ,MUSCULOSKELETAL system physiology ,NEUROPHYSIOLOGY ,RESEARCH funding ,STATISTICS ,T-test (Statistics) ,WALKING ,DATA analysis ,STATISTICAL reliability ,HAMSTRING muscle ,QUADRICEPS muscle ,NEUROMUSCULAR system ,CASE-control method ,RESEARCH methodology evaluation ,DATA analysis software ,STROKE rehabilitation ,INTRACLASS correlation - Abstract
Objectives: Restoration of walking is a priority for stroke survivors and key target for physical therapies. Upright pedalling (UP) can provide functional walking‐like activity using a variety of muscle synergies; it is unclear which synergies might be most useful for recovery of walking. Objectives here were as follows: to examine whether neuromuscular measures derived during UP might identify targets for walking rehabilitation after stroke andto determine test–retest repeatability and concurrent validity of the measures. Design This was a prospective correlational study. Setting: The study was carried out in a movement science laboratory. Participants The participants were 18 adults with stroke (StrS) and 10 healthy older adults (HOA). Intervention/measurement: StrS and HOA took part in two identical measurement sessions. During UP, surface electromyography and kinematic data were recorded and then processed to derive three measures: reciprocal activity of quadriceps and hamstrings;percentage muscle activity "on" according to crank angle; andsmoothness of movement. Results: HOA and StrS demonstrated differences in reciprocal muscle activity (p =.044) and quadriceps activity according to crank angle (p =.034) but pedalled similarly smoothly (p =.367). For muscle activation according to crank angle in StrS, intraclass correlation coefficients (95% confidence interval) showing acceptable repeatability were 0.46 [0.32, 0.58] affected quadriceps; 0.43 [0.28, 0.56] affected hamstrings; and 0.67 [0.56, 0.75] unaffected quadriceps. Conclusion: Muscle activation according to crank angle is a promising measure of lower limb impairment during functional activity after stroke; subsequent investigation should determine magnitude of variance between testing sessions. Reciprocal activity of quadriceps and hamstrings muscles and quadriceps activity according to crank angle are both potential targets for physical therapies to improve motor recovery. Further investigations are warranted. [ABSTRACT FROM AUTHOR]
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- 2020
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6. Functional Strength Training and Movement Performance Therapy for Upper Limb Recovery Early Poststroke--Efficacy, Neural Correlates, Predictive Markers, and Cost-Effectiveness: Fast-INdiCATE Trial.
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Hunter, Susan M., Johansen-Berg, Heidi, Ward, Nick, Kennedy, Niamh C., Chandler, Elizabeth, Weir, Christopher John, Rothwell, John, Wing, Alan M., Grey, Michael J., Barton, Garry, Leavey, Nick Malachy, Havis, Claire, Lemon, Roger N., Burridge, Jane, Dymond, Amy, and Pomeroy, Valerie M.
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STROKE treatment ,PHYSICAL therapy - Abstract
Background: Variation in physiological deficits underlying upper limb paresis after stroke could influence how people recover and to which physical therapy they best respond. Objectives: To determine whether functional strength training (FST) improves upper limb recovery more than movement performance therapy (MPT). To identify: (a) neural correlates of response and (b) whether pre-intervention neural characteristics predict response. Design: Explanatory investigations within a randomised, controlled, observer-blind, and multicentre trial. Randomisation was computer-generated and concealed by an independent facility until baseline measures were completed. Primary time point was outcome, after the 6-week intervention phase. Follow-up was at 6 months after stroke. Participants: With some voluntary muscle contraction in the paretic upper limb, not full dexterity, when recruited up to 60 days after an anterior cerebral circulation territory stroke. Interventions: Conventional physical therapy (CPT) plus either MPT or FST for up to 90 min-a-day, 5 days-a-week for 6 weeks. FST was "hands-off" progressive resistive exercise cemented into functional task training. MPT was "hands-on" sensory/facilitation techniques for smooth and accurate movement. Outcomes: The primary efficacy measure was the Action Research Arm Test (ARAT). Neural measures: fractional anisotropy (FA) corpus callosum midline; asymmetry of corticospinal tracts FA; and resting motor threshold (RMT) of motor-evoked potentials. Analysis: Covariance models tested ARAT change from baseline. At outcome: correlation coefficients assessed relationship between change in ARAT and neural measures; an interaction term assessed whether baseline neural characteristics predicted response. Results: 288 Participants had: mean age of 72.2 (SD 12.5) years and mean ARAT 25.5 (18.2). For 240 participants with ARAT at baseline and outcome the mean change was 9.70 (11.72) for FST + CPT and 7.90 (9.18) for MPT + CPT, which did not differ statistically (p = 0.298). Correlations between ARAT change scores and baseline neural values were between 0.199, p = 0.320 for MPT + CPT RMT (n = 27) and -0.147, p = 0.385 for asymmetry of corticospinal tracts FA (n = 37). Interaction effects between neural values and ARAT change between baseline and outcome were not statistically significant. Conclusions: There was no significant difference in upper limb improvement between FST and MPT. Baseline neural measures did not correlate with upper limb recovery or predict therapy response. Trial registration: Current Controlled Trials: ISRCT 19090862, http://www.controlled- trials.com [ABSTRACT FROM AUTHOR]
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- 2018
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7. FAST INdiCATE Trial protocol. Clinical efficacy of functional strength training for upper limb motor recovery early after stroke: Neural correlates and prognostic indicators.
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Pomeroy, Valerie M., Ward, Nick S., Johansen-Berg, Heidi, Vliet, Paulette, Burridge, Jane, Hunter, Susan M., Lemon, Roger N., Rothwell, John, Weir, Christopher J., Wing, Alan, Walker, Andrew A., Kennedy, Niamh, Barton, Garry, Greenwood, Richard J., and McConnachie, Alex
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STROKE prognosis , *PHYSICAL therapy , *TREATMENT effectiveness , *MEDICAL rehabilitation , *BRAIN imaging , *RANDOMIZED controlled trials - Abstract
Rationale Functional strength training in addition to conventional physical therapy could enhance upper limb recovery early after stroke more than movement performance therapy plus conventional physical therapy. Aims To determine (a) the relative clinical efficacy of conventional physical therapy combined with functional strength training and conventional physical therapy combined with movement performance therapy for upper limb recovery; (b) the neural correlates of response to conventional physical therapy combined with functional strength training and conventional physical therapy combined with movement performance therapy; (c) whether any one or combination of baseline measures predict motor improvement in response to conventional physical therapy combined with functional strength training or conventional physical therapy combined with movement performance therapy. Design Randomized, controlled, observer-blind trial. Study The sample will consist of 288 participants with upper limb paresis resulting from a stroke that occurred within the previous 60 days. All will be allocated to conventional physical therapy combined with functional strength training or conventional physical therapy combined with movement performance therapy. Functional strength training and movement performance therapy will be undertaken for up to 1·5 h/day, five-days/week for six-weeks. Outcomes and Analysis Measurements will be undertaken before randomization, six-weeks thereafter, and six-months after stroke. Primary efficacy outcome will be the Action Research Arm Test. Explanatory measurements will include voxel-wise estimates of brain activity during hand movement, brain white matter integrity (fractional anisotropy), and brain-muscle connectivity (e.g. latency of motor evoked potentials). The primary clinical efficacy analysis will compare treatment groups using a multilevel normal linear model adjusting for stratification variables and for which therapist administered the treatment. Effect of conventional physical therapy combined with functional strength training versus conventional physical therapy combined with movement performance therapy will be summarized using the adjusted mean difference and 95% confidence interval. To identify the neural correlates of improvement in both groups, we will investigate associations between change from baseline in clinical outcomes and each explanatory measure. To identify baseline measurements that independently predict motor improvement, we will develop a multiple regression model. [ABSTRACT FROM AUTHOR]
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- 2014
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8. The FeSTivaLS trial protocol: A randomized evaluation of the efficacy of functional strength training on enhancing walking and upper limb function later post stroke.
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Mares, Kathryn, Cross, Jane, Clark, Allan, Barton, Garry R., Poland, Fiona, O'Driscoll, Marie-Luce, Watson, Martin J., McGlashan, Kate, Myint, Phyo K., and Pomeroy, Valerie M.
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STROKE ,WALKING ,MEDICAL rehabilitation ,PHYSICAL therapy ,EXERCISE ,RANDOMIZED controlled trials - Abstract
Rationale Functional Strength Training may enhance motor function of people who are more than six months post stroke. Aims to evaluate the clinical efficacy of enhancing upper and lower limb motor function with FST to explore participants' views (expectations and experiences) of FST, and to determine what cost-effectiveness data to collect in a subsequent Phase III trial. Design Randomized, observer-blind trial with embedded qualitative investigation of participants' views of FST ( n = 6, purposive sampling). Study Participants ( n = 58), six months to five years after stroke with difficulty using their paretic upper ( UL) and lower limbs ( LL) for everyday functional activity. All will be randomized to either FST-UL or FST-LL delivered in their own homes for fours days each week for six weeks. FST involves repetitive progressive resisted exercise during goal directed functional activities. The therapist's main input is to provide verbal prompting and feedback. Outcomes Measures will be undertaken before randomization (baseline), after the six-week intervention (outcome) and six weeks thereafter (follow-up). Primary outcomes for clinical efficacy will be the Functional Ambulation Categories ( FAC) and the Action Research Arm Test ( ARAT). Clinical efficacy analysis will use the proportional odds model for FAC and a Mann- Whitney test for ARAT. Participants' views of FST will be explored at baseline and outcome through audiotaped, semi-structured, narrative approach, interviews. The analytic process for interviews will sort transcribed data thematically and seek categories to inform conceptualization (theory-building). A purpose-designed cost questionnaire will identify what cost resource items are likely to be affected by FST. [ABSTRACT FROM AUTHOR]
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- 2013
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9. Dose–Response Study of Mobilisation and Tactile Stimulation Therapy for the Upper Extremity Early After Stroke: A Phase I Trial.
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Hunter, Susan M., Hammett, Linda, Ball, Sue, Smith, Nina, Anderson, Cheryl, Clark, Allan, Tallis, Raymond, Rudd, Anthony, and Pomeroy, Valerie M.
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Background. Physical therapy doses may need to be higher than provided in current clinical practice, especially for patients with severe paresis. The authors aimed to find the most effective and feasible dose of Mobilisation and Tactile Stimulation (MTS), which includes joint and soft-tissue mobilization and passive or active-assisted movement to enhance voluntary muscle contraction. Methods. This 2-center, randomized, controlled, observer-blinded feasibility trial compared conventional rehabilitation but no extra therapy (group 1) with conventional therapy plus 1 of 3 daily doses of MTS, up to 30 (group 2), 60 (group 3), or 120 (group 4) minutes for 14 days. The 76 participants had substantial paresis (Motricity Index [MI] < 61) a mean of 30 days (standard deviation [SD] = 20 days) after anterior circulation stroke. MTS was delivered using a standardized schedule of techniques (eg, sensory input, active-assisted movement). The primary outcome was the Motricity Index (MI) and secondary outcome was the Action Research Arm Test (ARAT) tested on day 16. Adverse events were monitored daily. Results. No difference was found in the change in control group MI compared with each of the 3 intervention groups (P = .593) or in the ARAT. Mean actual daily treatment time for all MTS groups was less than expected. The attrition rate was 1.3%. No adverse events related to overuse occurred. Conclusion. The authors were not able to deliver a maximum dose of 120 minutes of daily therapy each day. The mean daily dose of MTS feasible for subsequent evaluation is between 37 and 66 minutes. [ABSTRACT FROM PUBLISHER]
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- 2011
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10. Efficacy of Functional Strength Training on Restoration of Lower-Limb Motor Function Early After Stroke: Phase I Randomized Controlled Trial.
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Cooke, Emma V., Tallis, Raymond C., Clark, Allan, and Pomeroy, Valerie M.
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After stroke, physiotherapy can promote brain reorganization and motor recovery. Combining muscle strength and functional training (functional strength training, FST) may be beneficial. The aim of the authors was to compare FST with conventional physiotherapy (CPT) while controlling for the potential confounder of therapy intensity in a multicenter, randomized controlled observer-blind trial. The mean age of the participants was 68.3 (standard deviation [SD] = 12.03) years at a mean of 34 (SD = 20) days after stroke, with mean peak paretic knee extension torque (torque) of 22 (SD = 25) Nm. The estimated sample size was 102 to detect a between-group difference of 0.2 m/s in walking speed. After baseline measures, participants were allocated randomly to CPT or CPT + CPT or CPT + FST for 6 weeks. Additional experimental therapy was provided for up to 1 hour a day, 4 times each week. Outcomes were measured 6 weeks after baseline and at follow-up 12 weeks thereafter. Measures included walking speed, knee extensor torque, and functional mobility (Rivermead). At outcome, both extraintensity groups showed greater increases in walking speed than the CPT group, but this reached significance only for the CPT + CPT group (P = .031). The CPT + CPT group also had a greater number of participants who walked at 0.8 m/s or above. No significant differences were observed for torque about the knee or for the Rivermead score. At follow-up, no significant differences were observed. These phase I results justify a subsequent trial of CPT + CPT versus CPT + FST. [ABSTRACT FROM AUTHOR]
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- 2010
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11. Effects of Mobilization and Tactile Stimulation on Recovery of the Hemiplegic Upper Limb: A Series of Replicated Single-System Studies.
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Hunter, Susan M., Crome, Peter, Sim, Julius, and Pomeroy, Valerie M.
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Abstract: Hunter SM, Crome P, Sim J, Pomeroy VM. Effects of mobilization and tactile stimulation on recovery of the hemiplegic upper limb: a series of replicated single-system studies. Objective: To explore the effects on motor function and impairment of mobilization and tactile stimulation for the paretic arm and hand after stroke. Design: Replicated single-system series, ABA design. Setting: The stroke rehabilitation ward of a community hospital in the United Kingdom. Participants: Consecutive sample, men and women (N=6) with stroke (left or right), within 3 months of onset. Intervention: Sixty minutes of daily mobilization and tactile stimulation to the paretic arm and hand for 6 weeks in addition to the usual rehabilitation program. Main Outcome Measures: Focal disability (Action Research Arm Test [ARAT]) and motor impairment (Motricity Index arm section). Results: All participants showed visual change in 1 or more of trend, level, or slope between baseline and intervention phases for both the ARAT and the Motricity Index. The visual analysis was confirmed through statistical testing (c statistic and/or Mann-Whitney U test) for 5 of 6 participants (statistical analysis was precluded for 1 participant). No further improvements were made on intervention withdrawal. Conclusions: This study shows proof of concept for using mobilization and tactile stimulation to improve motor recovery after severe paresis, justifying conducting dose-finding studies as a precursor to multicenter phase III clinical trials. [Copyright &y& Elsevier]
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- 2008
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12. Motor Imagery to Enhance Recovery After Subcortical Stroke:Who Might Benefit, Daily Dose, and Potential Effects.
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Simmons, Lucy, Sharma, Nikhil, Baron, Jean-Claude, and Pomeroy, Valerie M.
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Background. Motor imagery may enhance motor recovery after stroke. Objectives. To estimate the proportion of patients able to perform motor imagery, the feasibility of delivery of motor imagery training (MIT), and the effects of MIT on motor recovery in an exploratory study.Methods.An immediate pretreatment and posttreatment single-group design was used to study 10 patients after subcortical stroke with neuromuscular weakness in the upper limb. MIT that included upper limb activities reflecting everyday tasks was provided for 10 consecutive working days. Measures included assessment of chaotic motor imagery, patient report of tolerability of MIT, Motricity Index (MI), Nine Hole Peg Test (9HPT), and quality of movement (MAL-QOM). MIT dose was changed in response to patient feedback. Graphed motor function scores were inspected visually for clinically important changes.Results. Four of the 10 patients were unable to perform motor imagery. Patient opinion was positive about the content and shaped daily dose of MIT given in two 20-minute periods separated by a 10-minute rest. Clinically important changes in motor scores were found. Four patients increased MI score (range 8-16), 3 patients increased 9HPT score (range 0.02-0.04 pegs/second), and 4 patients increased MAL-QOM score (range 0.63-1.29). Conclusions. MIT was received positively by patients, but 40% were unable to perform imagery and interindividual variations were found on motor function. [ABSTRACT FROM AUTHOR]
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- 2008
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13. Challenges in integrating international evidence relating to stroke rehabilitation: experiences from a Cochrane systematic review.
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Pollock, Alex, Campbell, Pauline, Baer, Gillian, Choo, Pei Ling, Forster, Anne, Morris, Jacqui, Pomeroy, Valerie M, and Langhorne, Peter
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STROKE rehabilitation ,SYSTEMATIC reviews ,RANDOMIZED controlled trials ,MEDICAL care ,EVIDENCE-based medicine ,PHYSICAL therapy - Abstract
There are many randomized controlled trials relating to stroke rehabilitation being carried out in China, which are often published in Chinese-language journals. A recent update to our Cochrane systematic review of physical rehabilitation to improve function and mobility after stroke included 96 trials; over half (51) were conducted in China; 37 of these included studies were published in Chinese. Analyses within this Cochrane review support the conclusion that physical rehabilitation, using a mix of components from different approaches, is effective for the recovery of function and mobility after stroke. The inclusion of the Chinese studies had a substantial impact on the volume of evidence and, consequently, the conclusions. In this paper, we explore whether it is appropriate to draw implications for clinical practice throughout the world from evidence relating to a complex rehabilitation intervention delivered within one particular geographical healthcare setting. We explore the unique challenges associated with incorporating the body of evidence from China, particularly the Chinese-language publications, and identify the ongoing debate about the quality of Chinese research publications. We conclude that the growing body of evidence from China has important implications for future systematic reviews and evidence-based stroke care, but analysis and interpretation raise challenges, and improved reporting is critical. [ABSTRACT FROM AUTHOR]
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- 2014
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14. Mobility and dementia: is physiotherapy treatment during respite care effective?
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Pomeroy, Valerie M., Warren, Claire M., Honeycombe, Cheryl, Briggs, Roger S. J., Wilkinson, David G., Pickering, Ruth M., and Steiner, Andrea
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DEMENTIA , *LONG-term care of older people , *PHYSICAL therapy , *RESPITE care - Abstract
Background Mobility problems experienced by elderly people with a dementia are associated with falls, fractures and admission to long-term care. A hospital respite care admission is therefore often seen as an opportunity to provide physiotherapy treatment. Aim To find whether elderly people with a dementia and a mobility problem show a greater improvement in mobility skills if given physiotherapy treatment than if given non-physical activities intervention during a hospital respite admission. Method A controlled randomized multicentre trial with independent blinded assessment. The Southampton Mobility Assessment (mobility score) and Two Minute Walking Test (distance walked) were undertaken at the beginning and end of the study admission and beginning of the next respite admission. Following the first assessment, participants were randomized to either physiotherapy or activities. Results Eighty-one participants, from 12 clinical centres, with a mean age of 81.9 years and CAPE I/O score of 2. During the study admission there was a non-significant trend for a lower reduction in mobility score of the physiotherapy group (Mann-Whitney; p =0.614) and a non-significant trend for greater decrease in distance walked in the activities group (t -test; p =0.325). Discussion The results of this trial do not support the positive changes demonstrated elsewhere. However, changes in respite care during the early stages of this trial may have produced differences between the sample for this trial and that for the pilot study. This trial was therefore underpowered. Conclusion This trial suggests that future research needs to change the focus from clinical settings to presentations. Copyright © 1999 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
- Published
- 1999
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15. Correlations between arm motor behavior and brain function following bilateral arm training after stroke: a systematic review.
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Choo, Pei Ling, Gallagher, Helen L., Morris, Jacqui, Pomeroy, Valerie M., and Wijck, Frederike
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STROKE , *MOTOR ability , *NEUROPLASTICITY , *MEDICAL rehabilitation , *SYSTEMATIC reviews - Abstract
Background: Bilateral training (BT) of the upper limb (UL) might enhance recovery of arm function after stroke. To better understand the therapeutic potential of BT, this study aimed to determine the correlation between arm motor behavior and brain structure/function as a result of bilateral arm training poststroke. Methods: A systematic review of quantitative studies of BT evaluating both UL motor behavior and neuroplasticity was conducted. Eleven electronic databases were searched. Two reviewers independently selected studies, extracted data and assessed methodological quality, using the Effective Public Health Practice Project (EPHPP) tool. Results: Eight studies comprising 164 participants met the inclusion criteria. Only two studies rated "strong" on the EPHPP tool. Considerable heterogeneity of participants, BT modes, comparator interventions and measures contraindicated pooled outcome analysis. Modes of BT included: in-phase and anti-phase; functional movements involving objects; and movements only. Movements were mechanically coupled, free, auditorycued, or self-paced. The Fugl-Meyer Assessment (UL section) was used in six of eight studies, however, different subsections were used by different studies. Neural correlates were measured using fMRI and TMS in three and five studies, respectively, using a wide variety of variables. Associations between changes in UL function and neural plasticity were inconsistent and only two studies reported a statistical correlation following BT. Conclusions: No clear pattern of association between UL motor and neural response to BT was apparent from this review, indicating that the neural correlates of motor behavior response to BT after stroke remain unknown. To understand the full therapeutic potential of BT and its different modes, further investigation is required. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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