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The article presents a study which investigates the histologic appearance and pattern of the spread of primary tumors with sarcomatoid characteristics in renal cells. It mentions that the study utilizes patients with sarcomatoid histology who are admitted at the University of California, Los Angeles from 1989-2007. Results of the nephrectomy show that the sarcomatoid features are oftentimes observed in the metastases with a solitary pattern that supports the subclone hypothesis.

The article discusses a study which investigates the cancer-specific survival outcomes among patients with renal cell carcinoma (RCC) who were treated during the cytokine era from 1989-2005. It reveals that most patients with localized RCC have improved with surgery alone, however, effective adjuvant therapy is required for patients who were at high risk for recurrence. Moreover, less toxic treatments should be at least effective like surgical resection and immunotherapy for advanced disease.

The article focuses on the study of Eastern Cooperative Oncology Group (ECOG) on the effect of cytoreductive nephrectomy (CN) on the performance status (PS) or well-being of patients with kidney cancer. It notes that the outcome of the review of the demography and medical accounts of 418 patients who had CN from 1989 to 2006 were correlated to ECOG PS. Younger patients were noted to have higher tumor classification and generally shows anemia and bone metastases (BM).