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Your search keyword '"Ethylene Glycols administration & dosage"' showing total 16 results
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16 results on '"Ethylene Glycols administration & dosage"'

1. The effects of ethylene glycol monomethyl ether on female reproductive system in juvenile rats.

Author

Taketa Y, Mineshima H, Ohta E, and Nakano-Ito K

Subjects
Animals, Corpus Luteum drug effects, Dose-Response Relationship, Drug, Estrous Cycle drug effects, Ethylene Glycols administration & dosage, Female, Ovulation drug effects, Pregnancy, Puberty drug effects, Rats, Sprague-Dawley, Weight Gain drug effects, Ethylene Glycols adverse effects, Ethylene Glycols toxicity, Reproduction drug effects
Abstract

Ethylene glycol monomethyl ether (EGME), which is widely used in various industrial products, is known for adverse effects on the reproductive system in adult rats. However, the effects of EGME on reproductive development in juvenile rats have not been demonstrated. In order to investigate the effects of EGME on the female reproductive system and pubertal development in juvenile rats, EGME was administered to female Sprague Dawley rats from postnatal day 21 to 41 at a dose level of 0, 50, 100, or 300 mg/kg. The animals were examined for general condition, body weight, vaginal opening (VO), estrous cyclicity, and histopathology of reproductive organs. EGME treatment resulted in a prolonged estrous cycle interval characterized by persistent diestrus at 50 mg/kg without effects on body weight, timing of VO, or histology of the reproductive organs. EGME at 100 mg/kg induced decreases in body weight gain, a delay of VO, and irregular estrous cycle with absence of corpora lutea and hypertrophy of uterine epithelium indicating disturbance of the ovulatory process associated with hormonal effect. At 300 mg/kg, there was significant delay of puberty due to severe growth retardation. The present results revealed that irregular estrous cycle is a first indicator of the effects of EGME on the female reproductive system in juvenile rats, with delayed pubertal onset and ovulatory process disturbance at a higher dose.

Published
2017
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2. Reproductive toxicology. Triethylene glycol diacetate.

Subjects
Animals, Body Weight drug effects, Dose-Response Relationship, Drug, Ethylene Glycols administration & dosage, Female, Fertility drug effects, Kidney drug effects, Kidney pathology, Male, Mice, Organ Size drug effects, Pregnancy, Ethylene Glycols toxicity, Reproduction drug effects
Published
1997

3. Reproductive toxicology. Ethylene glycol monomethyl ether.

Subjects
Animals, Birth Weight drug effects, Body Weight drug effects, Dose-Response Relationship, Drug, Estrus drug effects, Ethylene Glycols administration & dosage, Female, Fertility drug effects, Genitalia, Male drug effects, Genitalia, Male pathology, Litter Size drug effects, Liver drug effects, Liver pathology, Male, Mice, Organ Size drug effects, Pregnancy, Solvents administration & dosage, Solvents toxicity, Ethylene Glycols toxicity, Reproduction drug effects
Published
1997

4. Reproductive toxicology. Ethylene glycol monomethyl ether.

Subjects
Animals, Body Weight drug effects, Dose-Response Relationship, Drug, Epididymis drug effects, Epididymis pathology, Ethylene Glycols administration & dosage, Female, Fertility drug effects, Fetal Death chemically induced, Litter Size drug effects, Liver drug effects, Liver pathology, Male, Mice, Mice, Inbred C3H, Organ Size drug effects, Pregnancy, Prostate drug effects, Prostate pathology, Seminal Vesicles drug effects, Seminal Vesicles pathology, Solvents administration & dosage, Solvents toxicity, Species Specificity, Sperm Count drug effects, Spermatozoa abnormalities, Spermatozoa drug effects, Testis drug effects, Testis pathology, Ethylene Glycols toxicity, Reproduction drug effects
Published
1997

5. Reproductive toxicology. Ethylene glycol monobutyl ether.

Subjects
Animals, Birth Weight drug effects, Body Weight drug effects, Dose-Response Relationship, Drug, Drinking drug effects, Ethylene Glycols administration & dosage, Female, Kidney drug effects, Kidney pathology, Litter Size drug effects, Liver drug effects, Liver pathology, Male, Mice, Organ Size drug effects, Pregnancy, Solvents administration & dosage, Solvents toxicity, Testis drug effects, Testis pathology, Ethylene Glycols toxicity, Reproduction drug effects
Published
1997

6. Reproductive toxicology. Ethylene glycol monoethyl ether (2-ethoxyethanol).

Subjects
Animals, Body Weight drug effects, Brain drug effects, Brain pathology, Dose-Response Relationship, Drug, Estrus drug effects, Ethylene Glycols administration & dosage, Female, Fertility drug effects, Genitalia drug effects, Genitalia pathology, Litter Size drug effects, Liver drug effects, Liver pathology, Male, Mice, Organ Size drug effects, Pregnancy, Solvents administration & dosage, Solvents toxicity, Sperm Count drug effects, Sperm Motility drug effects, Spermatozoa abnormalities, Spermatozoa drug effects, Testis drug effects, Testis pathology, Ethylene Glycols toxicity, Reproduction drug effects
Published
1997

7. Reproductive toxicology. Ethylene glycol monoethyl ether acetate.

Subjects
Animals, Birth Weight drug effects, Body Weight drug effects, Dose-Response Relationship, Drug, Drinking drug effects, Ethylene Glycols administration & dosage, Female, Fertility drug effects, Litter Size drug effects, Liver drug effects, Liver pathology, Male, Mice, Organ Size drug effects, Pregnancy, Solvents administration & dosage, Solvents toxicity, Sperm Count drug effects, Spermatozoa abnormalities, Spermatozoa drug effects, Testis drug effects, Testis pathology, Ethylene Glycols toxicity, Reproduction drug effects
Published
1997

8. Reproductive toxicology. Ethylene glycol monophenyl ether.

Subjects
Animals, Birth Weight drug effects, Body Weight drug effects, Dose-Response Relationship, Drug, Ethylene Glycols administration & dosage, Female, Fertility drug effects, Litter Size drug effects, Liver drug effects, Liver pathology, Male, Mice, Organ Size drug effects, Pregnancy, Solvents administration & dosage, Solvents toxicity, Testis drug effects, Testis pathology, Ethylene Glycols toxicity, Reproduction drug effects
Published
1997

9. Reproductive toxicology. Ethylene glycol monomethyl ether.

Subjects
Animals, Body Weight drug effects, Dose-Response Relationship, Drug, Epididymis drug effects, Epididymis pathology, Ethylene Glycols administration & dosage, Female, Fertility drug effects, Fetal Death chemically induced, Kidney drug effects, Kidney pathology, Litter Size drug effects, Liver drug effects, Liver pathology, Male, Mice, Mice, Inbred C57BL, Organ Size drug effects, Ovary drug effects, Ovary pathology, Pregnancy, Solvents administration & dosage, Solvents toxicity, Species Specificity, Sperm Count drug effects, Sperm Motility drug effects, Spermatozoa abnormalities, Spermatozoa drug effects, Ethylene Glycols toxicity, Reproduction drug effects
Published
1997

10. Reproductive toxicology. Ethylene glycol.

Subjects
Abnormalities, Drug-Induced pathology, Animals, Birth Weight drug effects, Bone and Bones abnormalities, Brain drug effects, Brain pathology, Dose-Response Relationship, Drug, Ethylene Glycol, Ethylene Glycols administration & dosage, Female, Litter Size drug effects, Liver drug effects, Liver pathology, Male, Mice, Organ Size drug effects, Pregnancy, Solvents administration & dosage, Solvents toxicity, Ethylene Glycols toxicity, Reproduction drug effects
Published
1997

11. Reproductive toxicology. Diethylene glycol.

Subjects
Animals, Body Weight drug effects, Dose-Response Relationship, Drug, Ethylene Glycols administration & dosage, Female, Litter Size drug effects, Male, Mice, Pregnancy, Solvents administration & dosage, Solvents toxicity, Ethylene Glycols toxicity, Reproduction drug effects
Published
1997

12. Reproductive toxicology. Ethylene glycol.

Subjects
Abnormalities, Drug-Induced pathology, Animals, Birth Weight drug effects, Body Weight drug effects, Bone and Bones abnormalities, Dose-Response Relationship, Drug, Ethylene Glycol, Ethylene Glycols administration & dosage, Female, Litter Size drug effects, Male, Mice, Organ Size drug effects, Pregnancy, Solvents administration & dosage, Solvents toxicity, Testis drug effects, Testis pathology, Ethylene Glycols toxicity, Reproduction drug effects
Published
1997

13. Reproductive toxicology. Ethylene glycol monomethyl ether: litter five.

Subjects
Animals, Birth Weight drug effects, Body Weight drug effects, Dose-Response Relationship, Drug, Epididymis drug effects, Epididymis pathology, Ethylene Glycols administration & dosage, Female, Kidney drug effects, Kidney pathology, Litter Size drug effects, Liver drug effects, Liver pathology, Male, Organ Size drug effects, Pregnancy, Rats, Rats, Sprague-Dawley, Research Design, Solvents administration & dosage, Solvents toxicity, Species Specificity, Testis drug effects, Testis pathology, Ethylene Glycols toxicity, Reproduction drug effects
Published
1997

14. Reproductive toxicology. Ethylene glycol monomethyl ether: litter two.

Subjects
Animals, Body Weight drug effects, Dose-Response Relationship, Drug, Epididymis drug effects, Epididymis pathology, Ethylene Glycols administration & dosage, Female, Fertility drug effects, Fetal Death chemically induced, Kidney drug effects, Kidney pathology, Litter Size drug effects, Liver drug effects, Liver pathology, Male, Organ Size drug effects, Pregnancy, Prostate drug effects, Prostate pathology, Rats, Rats, Sprague-Dawley, Seminal Vesicles drug effects, Seminal Vesicles pathology, Solvents administration & dosage, Solvents toxicity, Species Specificity, Sperm Count drug effects, Sperm Motility drug effects, Testis drug effects, Testis pathology, Ethylene Glycols toxicity, Reproduction drug effects
Published
1997

15. Reproductive toxicology. Diethylene glycol monoethyl ether.

Subjects
Animals, Brain drug effects, Brain pathology, Dose-Response Relationship, Drug, Ethylene Glycols administration & dosage, Female, Liver drug effects, Liver pathology, Male, Mice, Organ Size drug effects, Pregnancy, Solvents administration & dosage, Solvents toxicity, Sperm Count drug effects, Sperm Motility drug effects, Ethylene Glycols toxicity, Reproduction drug effects
Published
1997

16. Reproductive toxicology. Ethylene glycol monomethyl ether.

Subjects
Animals, Dose-Response Relationship, Drug, Epididymis drug effects, Epididymis pathology, Ethylene Glycols administration & dosage, Female, Fertility drug effects, Fetal Death chemically induced, Kidney drug effects, Kidney pathology, Litter Size drug effects, Liver drug effects, Liver pathology, Male, Mice, Organ Size drug effects, Pregnancy, Solvents administration & dosage, Solvents toxicity, Species Specificity, Spermatozoa abnormalities, Spermatozoa drug effects, Testis drug effects, Testis pathology, Ethylene Glycols toxicity, Reproduction drug effects
Published
1997

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