1. A three generation reproduction study with Sprague-Dawley rats consuming high-amylose transgenic rice.
- Author
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Zhou XH, Dong Y, Zhao YS, Xiao X, Wang Y, He YQ, and Liu QQ
- Subjects
- Amylose analysis, Animals, Body Weight drug effects, Diet, Eating drug effects, Female, Food, Fortified adverse effects, Food, Fortified analysis, Male, Ovary drug effects, Ovary pathology, Plants, Genetically Modified adverse effects, Plants, Genetically Modified chemistry, Plants, Genetically Modified genetics, Rats, Sprague-Dawley, Testis drug effects, Testis pathology, Amylose metabolism, Oryza adverse effects, Oryza chemistry, Oryza genetics, Reproduction drug effects
- Abstract
The transgenic rice line (TRS) enriched with amylose and resistant starch (RS) was developed by antisense RNA inhibition of starch-branching enzymes. Cereal starch with high amylose has a great benefit on human health through its resistant starch. In order to evaluate the effect of transgenic rice on rats, the rats were fed diets containing 70% TRS rice flour, its near-isogenic rice flour or the standard diet as the control through three generations. In the present study, clinical performance, reproductive capacity and pathological responses including body weight, food consumption, reproductive data, hematological parameters, serum chemistry components, organ relative weights and histopathology were examined. Some statistically significant differences were observed in rats consuming the high amylose rice diet when compared to rats fed the near-isogenic control rice diet or the conventional (non-rice) standard diet. These differences were generally of small magnitude, appeared to be random in nature, and were within normal limits for the strain of rat used, and were therefore not considered to be biologically meaningful or treatment related., (Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2014
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