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Enantioselective catalysts produce organic compounds in enantiomerically enriched form. They are highly efficient tools for the syhthesis of biologically active materials, such as pharmaceuticals and crop-protection chemicals, in which enantiomeric purity can be critical. The design of chiral ligands is the key to developing new enantioselective catalysts. Three unusual families of ligands have been used to develop practical technology for enantioselective hydrocyanation of olefins, ring-opening of epoxides, and hydrogenation of various compounds., Enantioselective catalysis is bringing about a revolution in asymmetric synthesis. Seldom has there been an area of chemistry where the scientific goals are so challenging, the economic benefits so obvious, [...]

A two-state, four-orbital, independent electron analysis of the first optical molecular hyperpolarizability, Β, leads to the prediction that [vertical bar] Β [vertical bar] maximizes at a combination of donor and [...]

Induction of an Antibody Tha Catalyzes the Hydrolysis of an Amide Bond ANTIBODIES ARE CAPABLE OF CATALYZING A VARIETY OF chemical transformation (1-14). Antigens can be fabricated that structurally resemble [...]

Direct Bronsted Analysis of the Restoration of Activity to a Mutant Enzyme by Exogenous Amines ENZYMOLOGISTS HAVE BEEN ABLE TO adapt most of the tools of the physical organic chemist [...]

Physical inclusion of small molecules in larger structural lattices is well known in the crystalline state and is a common feature of the chemistry of zeolites. In the liquid state, a variety of synthetic macrocyclic molecules are available to complex and contain smaller guest species. An alternative strategy for binding is explored: assembly of cavity-forming structures from smaller subunits. Encapsulation of small guest molecules such as methane can be achieved with a synthetic structure that assembles reversibly through hydrogen bonding., Studies of molecular recognition phenomena have led to increasingly sophisticated compounds--cryptands (1), cryptophanes (2), and carcerands (3)--for binding ions and small molecules. These covalently bound structures feature macrocyclic shapes with [...]

The spherical geometry of buckminster-fullerene may have forged an unbreakable link between chemistry and soccer, but a group of chemists has now come up with another contender for the chemico-athletic [...]

Recognition and Transport of Adenine Derivatives with Synthetic Receptors MODEL RECEPTORS HAVE BEEN useful for exploring the intermolecular forces invqlved in the molecular recognition of adenine derivatives. Watson-Crick and Hoogsteen [...]

'Abzymes' Make Their Mark? Mother Nature does not always provide biochemists with all the tools that they would like to have. They would say she has been lax, for example, [...]