1. Combination of mesenchymal stem cell injection with icariin for the treatment of diabetes-associated erectile dysfunction
- Author
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Chen Weihao, Wang Yi, Xie Changliang, Zhang Xinyu, Maojun Zhou, Xiyou Wang, Yansheng Xu, Chuanhai Liu, Ping Chen, Shen Yue, Yong Xu, Yun Ouyang, Yubo Zhao, and Liu Cuilong
- Subjects
0301 basic medicine ,Oncology ,Male ,Cell Transplantation ,030232 urology & nephrology ,lcsh:Medicine ,Erectile tissue ,Apoptosis ,Pharmacology ,medicine.disease_cause ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Phosphatidylinositol 3-Kinases ,0302 clinical medicine ,Endocrinology ,Cell Signaling ,Erectile Dysfunction ,Animal Cells ,Medicine and Health Sciences ,Blood and Lymphatic System Procedures ,Medicine ,lcsh:Science ,Cells, Cultured ,Multidisciplinary ,Cell Death ,Stem Cells ,Stem Cell Therapy ,Graft Survival ,Oxidants ,Combined Modality Therapy ,Signaling Cascades ,STAT signaling ,medicine.anatomical_structure ,Adipose Tissue ,Cell Processes ,030220 oncology & carcinogenesis ,Cellular Types ,Injections, Intraperitoneal ,medicine.drug ,Research Article ,Signal Transduction ,STAT3 Transcription Factor ,medicine.medical_specialty ,Endocrine Disorders ,Cell Survival ,Urology ,Blotting, Western ,Surgical and Invasive Medical Procedures ,Mesenchymal Stem Cell Transplantation ,Stress Signaling Cascade ,Diabetes Mellitus, Experimental ,03 medical and health sciences ,Diabetes mellitus ,Internal medicine ,Diabetes Mellitus ,Humans ,Animals ,Protein kinase B ,PI3K/AKT/mTOR pathway ,Clinical Genetics ,Flavonoids ,Transplantation ,business.industry ,Mesenchymal stem cell ,lcsh:R ,Biology and Life Sciences ,Mesenchymal Stem Cells ,Cell Biology ,Hydrogen Peroxide ,Streptozotocin ,medicine.disease ,Oxidative Stress ,030104 developmental biology ,Erectile dysfunction ,chemistry ,Metabolic Disorders ,lcsh:Q ,business ,Icariin ,Proto-Oncogene Proteins c-akt ,Oxidative stress ,Stem Cell Transplantation ,Drugs, Chinese Herbal - Abstract
The present study was aimed to examine whether icariin, a traditional Chinese medicine, could improve therapeutic effects of adipose derived mesenchymal stem cells (ADSCs) for diabetes-associated erectile dysfunction (DMED). DMED were induced in rats by intraperitoneal injection of streptozotocin and confirmed by erectile function measurement. Then, rats of diabetic ED were randomly divided to receive the treatment of saline, ADSCs, icariin or ADSCs combined with icariin respectively. Compared with the treatment by ADSCs or icariin alone, intracavernosum injection of ADSCs combined with the following daily gastric gavage of icariin significantly augmented the value of ICP and ICP/MAP (p
- Published
- 2016