1. Contribution of Cyclin-dependent Kinase Inhibitor 1B Genotypes to Childhood Leukemia Risk
- Author
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PEI, JEN-SHENG, CHANG, WEN-SHIN, HSU, PEI-CHEN, CHEN, CHAO-CHUN, YANG, YA-CHEN, HSU, SHIH-WEI, HSU, YUAN-NIAN, WANG, YUN-CHI, WANG, CHUNG-HSING, TSAI, CHIA-WEN, and BAU, DA-TIAN
- Subjects
Pharmacology ,Cancer Research ,Gene Frequency ,Genotype ,Taiwan ,Humans ,Genetic Predisposition to Disease ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Child ,Polymorphism, Single Nucleotide ,Cyclin-Dependent Kinase Inhibitor p27 ,General Biochemistry, Genetics and Molecular Biology ,Research Article - Abstract
Background/Aim: Although genetic differences in cell-cycle control genes have been associated with cancer risk, to our knowledge, no report has specifically examined the role of gene variants in childhood acute lymphoblastic leukemia (ALL). Cyclin-dependent kinase inhibitor 1B (CDKN1B; also known as p27/KIP1) is a cell-cycle regulating gene. This study aimed at investigating the association between CDKN1B genotypes and childhood ALL risk. Materials and Methods: In 266 childhood ALL cases and 266 healthy controls, the CDKN1B rs34330 and 2066827 polymorphisms were genotyped, and the association of CDKN1B genotypes with childhood ALL risk were analyzed. Results: The genotypes of CDKN1B rs34330 and 2066827 were similarly distributed between the control and case groups (p for trend=0.8718 and 0.4030, respectively). The allelic frequency also exhibited no statistical difference (p=1.0000 and 0.6666, respectively). There was no significant interaction between CDKN1B genotypes and age or sex. Conclusion: CDKN1B genotypes were not found to be minor contributors to childhood ALL susceptibility in Taiwan.
- Published
- 2022