1. Hepatoprotective glycosides from the rhizomes of Imperata cylindrical.
- Author
-
Ma, Jie, Sun, Hua, Liu, Hui, Shi, Gao-Na, Zang, Ying-Da, Li, Chuang-Jun, Yang, Jing-Zhi, Chen, Fang-You, Huang, Ji-Wu, Zhang, Dan, and Zhang, Dong-Ming
- Subjects
HEPATOTOXICOLOGY ,ALTERNATIVE medicine ,ANIMAL experimentation ,ANTIOXIDANTS ,BIOLOGICAL assay ,BIOLOGICAL models ,PHYSICAL & theoretical chemistry ,GLYCOSIDES ,MACROPHAGES ,MEDICINAL plants ,LIPID peroxidation (Biology) ,MICE ,NUCLEAR magnetic resonance spectroscopy ,PROBABILITY theory ,RATS ,RESEARCH funding ,SPECTRUM analysis ,TUMOR necrosis factors ,PLANT extracts ,DESCRIPTIVE statistics ,IN vitro studies ,PREVENTION - Abstract
Three new C-methylated phenylpropanoid glycosides (1, 2), a new 8-4′-oxyneolignan (3), together with two known analogs (4, 5), were isolated from the rhizomes of Imperata cylindrical Beauv. var. major (Nees) C. E. Hubb. Their structures were determined by spectroscopic and chemical methods. Compounds 1, 2, and 5 (10 μM) exhibited pronounced hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage in vitro assays. Furthermore, their antioxidant activities against Fe
2+ -cysteine-induced rat liver microsomal lipid peroxidation and the effects on the secretion of TNF-α in murine peritoneal macrophages (RAW264.7) induced by lipopolysaccharides were evaluated. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF