1. In vivo study on the expression pattern of resistin in patients with abdominal aortic aneurysm.
- Author
-
Muehling BM, Paintner A, Marx N, Barth TF, Babiak C, and Orend KH
- Subjects
- Aged, Aged, 80 and over, Anti-Inflammatory Agents therapeutic use, Aorta, Abdominal drug effects, Aorta, Abdominal immunology, Aorta, Abdominal pathology, Aortic Aneurysm, Abdominal immunology, Aortic Aneurysm, Abdominal pathology, Aortic Aneurysm, Abdominal therapy, C-Reactive Protein analysis, Endovascular Procedures, Enzyme-Linked Immunosorbent Assay, Female, Germany, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Immunohistochemistry, Inflammation Mediators blood, Interleukin-10 blood, Male, Middle Aged, Treatment Outcome, Vascular Surgical Procedures, Aorta, Abdominal metabolism, Aortic Aneurysm, Abdominal metabolism, Resistin blood
- Abstract
Objective: To study the expression pattern of resistin in abdominal aortic aneurysms and to correlate its plasma levels to aneurysm size and statin therapy., Patients and Methods: From 25 patients on regular and 38 patients without statin therapy tissue specimen and plasma samples were obtained for analysis., Results: Demographic data, past medical history, and body mass index showed no significant differences between the statin and no statin group. Immunohistochemistry showed positive stainings for resistin in all sections and in part colocalization to CD 68 positive cells. Patients with large aneurysms showed significant correlation of C-reactive protein (CRP) and interleukin 10 (IL-10) levels; patients on statin medication had significantly lower plasma levels of resistin and CRP., Conclusion: In contrast to IL-10 and CRP plasma levels of resistin are not correlated to aneurysm diameter; yet statin therapy results in decrease of resistin and CRP, suggesting an anti-inflammatory action in patients with abdominal aortic aneurysms (AAAs).
- Published
- 2011
- Full Text
- View/download PDF