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The global burden of cancer is increasing rapidly, and nanomedicine offers promising prospects for enhancing the life expectancy of cancer patients. Janus nanoparticles (JNPs) have garnered considerable attention due to their asymmetric geometry, enabling multifunctionality in drug delivery and theranostics. However, achieving precise control over the self-assembly of JNPs in solution at the nanoscale level poses significant challenges. Herein, a low-temperature reversed-phase microemulsion system was used to obtain homogenous Mn3O4-Ag2S JNPs, which showed significant potential in cancer theranostics. Structural characterization revealed that the Ag2S (5–10 nm) part was uniformly deposited on a specific surface of Mn3O4 to form a Mn3O4-Ag2S Janus morphology. Compared to the single-component Mn3O4 and Ag2S particles, the fabricated Mn3O4-Ag2S JNPs exhibited satisfactory biocompatibility and therapeutic performance. Novel diagnostic and therapeutic nanoplatforms can be guided using the magnetic component in JNPs, which is revealed as an excellent T1 contrast enhancement agent in magnetic resonance imaging (MRI) with multiple functions, such as photo-induced regulation of the tumor microenvironment via producing reactive oxygen species and second near-infrared region (NIR-II) photothermal excitation for in vitro tumor-killing effects. The prime antibacterial and promising theranostics results demonstrate the extensive potential of the designed photo-responsive Mn3O4-Ag2S JNPs for biomedical applications. [ABSTRACT FROM AUTHOR]

Photo‐responsive combinational therapeutics attained significant attention in cancer theranostic owing to the versatile features of nanomaterials. The simplest nano‐design with unique properties to carry out multifunctionalties is a challenging assignment. Herein, a facile solvothermal method is employed to fabricate homogeneous MnO2 sea urchin‐shaped nanoparticles (MnO2‐OVA NPs) with a high loading capacity (86.15%) of ovalbumin (OVA) antigen. The prepared MnO2‐OVA NPs demonstrated excellent biocompatibility against different cell lines and significant cellular uptake, resulting in mature dendritic cells to enhance anti‐tumor immunity. The synthesized sea urchin‐shaped MnO2‐OVA NPs further exhibited self‐generated catalytic properties that efficiently relieve tumor hypoxia and improve cancer therapies. More excitingly, MnO2‐OVA NPs endorsed reactive oxygen species (ROS) in response of minute UV irradiation (mW) for photodynamic therapy. Further, the prepared photo‐responsive nanoparticles showed promising T1‐MR imaging and relaxivity properties for diagnosis and real‐time drug delivery monitoring. These synergetic therapeutic strategies produced by MnO2‐OVA NPs showed excellency as a potential theranostic agent. [ABSTRACT FROM AUTHOR]