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2 results on '"Doise JM"'

1. Amiodarone-related acute respiratory distress syndrome following sudden withdrawal of steroids.

Author

Charles PE, Doise JM, Quenot JP, Muller G, Aube H, Baudouin N, Piard F, Besancenot JF, and Blettery B

Subjects
Aged, Amiodarone administration & dosage, Anti-Arrhythmia Agents administration & dosage, Bronchoalveolar Lavage Fluid cytology, Bronchoalveolar Lavage Fluid microbiology, Fatal Outcome, Humans, Lung pathology, Male, Neutrophils metabolism, Papilledema chemically induced, Pneumonia chemically induced, Pneumonia pathology, Respiration, Artificial, Respiratory Distress Syndrome therapy, Shock, Septic microbiology, Staphylococcal Infections complications, Adrenal Cortex Hormones therapeutic use, Amiodarone adverse effects, Anti-Arrhythmia Agents adverse effects, Methylprednisolone therapeutic use, Papilledema drug therapy, Respiratory Distress Syndrome chemically induced
Abstract

Acute lung toxicity is a rare but classical complication of amiodarone therapy. We report the case of a patient who developed an optic neuropathy after 15 years of amiodarone administration, and who was treated for 2 weeks with steroids. Following withdrawal of steroids, the patient rapidly developed an acute respiratory distress syndrome. Postmortem lung histologic examination was consistent with amiodarone-induced pneumonitis. Since this complication is thought to be of immunological origin, we speculate that the sudden withdrawal of steroids was implicated in the development of the acute lung injury.

Published
2006
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2. An unusual cause of acute respiratory distress in a patient with AIDS: primary infection with Toxoplasma gondii.

Author

Charles PE, Doise JM, Quenot JP, Aube H, Dalle F, Bour JB, Chavanet P, and Blettery B

Subjects
AIDS-Related Opportunistic Infections drug therapy, Adult, Animals, Disease Progression, Drug Therapy, Combination, Fatal Outcome, Humans, Lung Diseases, Parasitic drug therapy, Male, Respiratory Distress Syndrome drug therapy, Respiratory Distress Syndrome microbiology, Severity of Illness Index, Toxoplasmosis drug therapy, AIDS-Related Opportunistic Infections diagnosis, Lung Diseases, Parasitic diagnosis, Respiratory Distress Syndrome diagnosis, Toxoplasma isolation & purification, Toxoplasmosis diagnosis
Abstract

Hypoxemic pneumonia in AIDS patients is mainly caused by Pneumocystis carinii, Toxoplasma gondii and CMV, although the significance of CMV recovery in BALF is often unclear. Since lung involvement generally occurs during reactivation, T. gondii is not expected to be demonstrated in patients without evidence of past infection with this agent. We report a fatal case of pneumonia revealing a T. gondii primary infection diagnosed thanks to the PCR analysis of the BALF.

Published
2003
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