1. Recombinant activated factor VII as a promising adjuvant therapy for postpartum hemorrhage in the practice of obstetric anesthesia: Experience from a university hospital in Taiwan.
- Author
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Jan, Jing-Yi, Lin, Shin-Yu, Lin, Chia-Hui, Lee, Chien-Nan, Fan, Shou-Zen, and Han, Yin-Yi
- Subjects
BLOOD coagulation factors ,ACADEMIC medical centers ,ANESTHESIA ,HEMORRHAGE ,MATERNAL health services ,CASE studies ,HEALTH outcome assessment ,PUERPERAL disorders ,TREATMENT effectiveness ,RETROSPECTIVE studies ,THERAPEUTICS - Abstract
Massive postpartum hemorrhage is one of the major complications in the peripartum period. In some critical cases, hemostasis is hard to achieve even after a hysterectomy has been performed. Recombinant activated factor VII has been reported as a promising adjuvant therapy for obstetric hemorrhage, although it remains unlicensed for this indication. Eight cases receiving recombinant activated factor VII in postpartum hemorrhage refractory to the conventional therapy in a Taiwanese hospital were analyzed retrospectively. A good response, defined as bleeding control in 15 min, was achieved in six patients (75%) with a single dose ranging from 55 to 105 mg/kg. The two patients with a poor response were later discovered to have had unsolved birth canal injuries. No drug-related adverse effects were noted. We recommend that any surgical bleeding should first be controlled, as well as the correction of metabolic and hematological abnormalities; however, in the situation of intractable postpartum hemorrhage, recombinant activated factor VII offers a salvage therapy and should be considered early, even before hysterectomy. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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