1. Intravenous immunoglobulin for patients with unexplained recurrent implantation failure: a 6-year single center retrospective review of clinical outcomes.
- Author
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Peero, Einav Kadour, Banjar, Shorooq, Khoudja, Rabea, Ton-leclerc, Shaonie, Beauchamp, Coralie, Benoit, Joanne, Beltempo, Marc, Dahan, Michael H., Gold, Phil, Kadoch, Isaac Jacques, Jamal, Wael, Laskin, Carl, Mahutte, Neal, Phillips, Simon, Sylvestre, Camille, Reinblatt, Shauna, Mazer, Bruce D., Buckett, William, and Genest, Genevieve more...
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EMBRYO implantation ,BLASTOCYST ,TREATMENT effectiveness ,LOGISTIC regression analysis ,RETROSPECTIVE studies ,INTRAVENOUS immunoglobulins - Abstract
The effectiveness of intravenous immunoglobulin (IVIg) for patients with unexplained recurrent implantation failure (uRIF) remains debated. We retrospectively analysed outcomes of uRIF patients treated with IVIg compared to a separate control uRIF cohort within our center (01/2014–12/2021). Primary outcomes included live birth, miscarriage, or transfer failure. We documented IVIg side effects and maternal/fetal outcomes. Logistic regression analysis was used to assess for association of IVIg exposure with outcomes and adjust for confounders. The study included 143 patients, with a 2:1 ratio of controls to patients receiving IVIg treatment. Patient characteristics were similar between groups. There was higher live birth rate (LBR) in patients receiving IVIg (32/49; 65.3%) compared to controls (32/94; 34%); p < 0.001). When stratifying patients into moderate and severe uRIF (respectively 3–4 and ≥ 5 previous good quality blastocyst transfer failures), only patients with severe uRIF benefited from IVIg (LBR (20/29 (69%) versus 5/25 (20%) for controls, p = 0.0004). In the logistic regression analysis, IVIg was associated with higher odds of live birth (OR 3.64; 95% CI 1.78–7.67; p = 0.0004). There were no serious adverse events with IVIg. IVIg can be considered in well selected patients with ≥ 5 previous unexplained, high quality blastocyst transfer failures. A randomized controlled trial is needed to confirm these findings. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
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