1. Nucleotide sequence of a radiation leukemia virus genome.
- Author
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Merregaert J, Janowski M, and Reddy EP
- Subjects
- Base Sequence, Leukemia Virus, Murine genetics, Protein Processing, Post-Translational, RNA, Viral genetics, Recombination, Genetic, Repetitive Sequences, Nucleic Acid, Viral Proteins genetics, Viral Proteins metabolism, Viral Structural Proteins, Genes, Viral, Retroviridae genetics
- Abstract
The complete nucleotide sequence of an infectious molecular clone of a radiation murine leukemia proviral DNA RadLV/VL3(T+L+) has been determined. The sequence of the RNA genome is 8318 nucleotides long and contains three large open reading frames encoding the gag, pol, and env gene products. With the exception of a xenotropiclike R peptide and the LTR which bears structural similarities to a xenotropic LTR, displaying typical enhancerlike sequences, the remaining sequences are strikingly similar to the endogenous, ecotropic Akv murine leukemia virus. Therefore, it could be postulated that the leukemogenic properties of RadLV/VL3(T+L+) were generated by a recombination event between a xenotropic virus and an Akv-like ecotropic virus.
- Published
- 1987
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