1. Multi-stage analysis of FOXM1, PYROXD1, hTERT, PPARA, PIM3, BMI1 and MCTP1 expression patterns in colorectal cancer.
- Author
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Shabani, Samira, Elahi, Elahe, Bahraniasl, Mandana, Babaheidarian, Pegah, Sadeghpour, Alireza, Majidzadeh, Tayebeh, Talebi, Atefeh, and Mahjoubi, Frouzandeh
- Subjects
REVERSE transcriptase polymerase chain reaction ,STAINS & staining (Microscopy) ,AGE distribution ,ONE-way analysis of variance ,COLORECTAL cancer ,TUMOR classification ,T-test (Statistics) ,GENE expression profiling ,TUMOR markers ,LYMPHOMAS ,DATA analysis software - Abstract
Aim: To explore biomarkers with a tumor stage-dependent expression pattern in patients with colorectal cancer (CRC). Background: The fourth most common cancer in the world is colorectal cancer (CRC). A variation in the gene expression rate is a common change in cancers initiation and the accumulation of these variation changes the behavior of normal cells and turns them into cancer cells. Methods: Real-time RT-PCR was used to investigate the expression patterns of the FOXM1, PYROXD1, hTERT, BMI, PPARA, PIM3 and MCTP1 genes in 54 patients with stage I to IV CRC and their relation with clinicopathological features of CRC were analyzed. Results: FOXM1, hTERT and MCTP1 genes are overexpressed in CRC tumor tissues when compared to normal adjacent tissues in all the stages. Results FOXM1, PYROXD1, hTERT, PM3, BMI1, PPARA and MCTP1 had-stage dependent expression. Investigation of the association between clinicopathological features and expression pattern of the studied genes revealed; a) a significant relationship between FOXM1 gene expression level and tumor stage, tumor size and lymph node involvement, b) a considerable association between alterations in PPARA and PIM3 expression and lymph node involvement, c) a notable correlation between hTERT expression level and the tumor stage and d) a strong correlation between MCTP1 expression and patient's age only. Conclusion: Our study indicates that expression profiles of these genes either individually or together can be applied as potential biomarkers for prognosis of CRC. [ABSTRACT FROM AUTHOR]
- Published
- 2022