19 results on '"SAHEBARI, Maryam"'
Search Results
2. Assessment of Treatment Safety and Quality of Life in Patients Receiving Etanercept Biosimilar for Autoimmune Arthritis (ASQA): A Multicenter Post-marketing Surveillance Study
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Gharibdoost, Farhad, Salari, Amir-Hossein, Salesi, Mansour, Ebrahimi Chaharom, Faegheh, Mottaghi, Peyman, Hosseini, Mansour, Sahebari, Maryam, Nazarinia, Mohammadali, Mirfeizi, Zahra, Shakibi, Mohammadreza, Moussavi, Hamidreza, Karimifar, Mansour, Mowla, Karim, Karimzadeh, Hadi, Anjidani, Nassim, and Jamshidi, Ahmadreza
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- 2021
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3. Correlation of US-7 and US-9 Scores with Disease Activity Score using 28 Joint Counts (DAS28) in Patients with Rheumatoid Arthritis.
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Ebadati, Sahar, Sahebari, Maryam, Ahmadzadeh, Amir Mahmoud, Emadzadeh, Maryam, Khoroushi, Farzaneh, Haghi, Hedieh Ragati, Giti, Ramesh, and Aminzadeh, Behzad
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CROSS-sectional method , *DOPPLER ultrasonography , *DATA analysis , *RHEUMATOID arthritis , *ULTRASONIC imaging , *QUANTITATIVE research , *JOINTS (Anatomy) , *STATISTICS , *DATA analysis software , *DISEASE progression - Abstract
Background: The attentive management of rheumatoid arthritis (RA) has attracted particular attention. The German 7-joint Ultrasound (US-7) is the first scoring system that combines bone erosions and soft tissue lesions in a single composite scoring system. This study aimed to assess the correlation between US-7 and Disease Activity Score Using 28 Joint Counts (DAS28) in clinically active RA patients. The efficacy of a novel ultrasound score-based system, the US-9 score (joints assessed with US-7 plus knees), was also compared with the standard US-7 score. Methods: All the RA patients referred to the outpatient rheumatology clinic of Ghaem Hospital, Mashhad, Iran, during 2019-2020 were included. 28 joints were clinically examined to calculate DAS28. Nine joints were assessed comprising the German US-7 plus knees using grayscale ultrasonography (GSUS) and power Doppler ultrasonography (PDUS). Retrieved data were analyzed by SPSS software, version 22. The Spearman Correlation test was used to find the correlation between DAS28 and ultrasonographic findings. The statistical significance level was set at P<0.05. Results: This study was composed of thirty-five RA patients with a mean age of 49.1±12.0 years. US-7 synovitis scores in GSUS and PDUS were significantly correlated with DAS28 (P=0.02, r=0.38 and P=0.003, r=0.48, respectively). US-9 synovitis scores in GSUS and PDUS were also significantly correlated with DAS28 (P=0.003, r=0.49 and P=0.006, r=0.45, respectively). The synovitis score measured by GSUS was significantly correlated with the GSUS knee synovial score (P=0.01, r=0.42). Conclusion: Ultrasound assessment of large joints such as knees can be an effective approach to determining RA severity. However, it can be proposed that adding more involved joints into the sonographic assessment does not necessarily provide a better clinical correlation. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Effects of Abatacept in Patients with Rheumatoid Arthritis and Cancer Risk: A Systematic Review.
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Homapoor, Saba, Sahebari, Maryam, and Khodashahi, Mandana
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RHEUMATOID arthritis , *DISEASE risk factors , *ABATACEPT , *AUTOIMMUNE diseases , *ANTIRHEUMATIC agents - Abstract
Introduction: As a chronic autoimmune disease, Rheumatoid arthritis (RA) affects the joints. Studies have shown a complex and challenging link between cancer and RA. However, articles claim a significant relationship between cancer and treatment with DMARDs and biological DMARDs (e.g., Abatacept); however, the results are contradictory. Accordingly, this systematic review investigates the prevalence of cancer in RA patients taking Abatacept. Methods: We searched for articles published in four databases, namely Web of Science, Medline, PubMed, and Scopus up to September 29, 2023. The methodology followed recommendations from the Cochrane Handbook. During the search process, we selected articles using keywords such as "rheumatoid arthritis", "malignancy", and "cancer" with the Boolean operators "AND" and "OR"." Results: A total of 12 studies were considered, the majority highlighted the effectiveness of Abatacept as an anti-RA medicine in the risk of cancer prevalence. Most of the patients investigated in the trials were female. Lung cancer was the greatest malignancy in those suffering from RA diseases. However, these investigations found no significant link between Abatacept use and cancer risk. Conclusion: There is speculation regarding the potential use of rheumatoid arthritis drugs in treating RA and its potential association with cancer incidence. According to the findings presented in this review article, there was no statistically significant association between the utilization of Abatacept and the prevalence of cancer in patients who were administered Abatacept either as a standalone treatment or in combination with other anti-rheumatoid medications. However, it is advised that further clinical trials be conducted to thoroughly investigate this association. [ABSTRACT FROM AUTHOR]
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- 2023
5. Effect of Oral Curcumin on Rheumatoid Arthritis Patients: A Double-Blind Randomized Clinical Trial.
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Rezaieyazdi, Zahra, Sarraf, Afshin, khodashahi, Mandana, Sahebari, Maryam, Jarahi, Lida, Rahimi, Hamid Reza, and Nabavi, Shima
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ORAL drug administration ,CURCUMIN ,MANN Whitney U Test ,ANTIRHEUMATIC agents ,RANDOMIZED controlled trials ,FUNCTIONAL assessment ,RHEUMATOID arthritis ,BLOOD sedimentation ,DESCRIPTIVE statistics ,BLIND experiment ,STATISTICAL sampling ,DATA analysis software - Abstract
Background & Objective: Incomprehensive studies have examined the therapeutic and side effects of curcumin on the treatment of debilitating diseases, such as Rheumatoid Arthritis (RA). This study aimed to explore the antiinflammatory effects of curcumin on RA. Materials & Methods: This double-blind clinical trial was carried out on 64 RA patients with an erythrocyte sedimentation rate (ESR)-Disease Activity Score (DAS)- 28>2.6. The patients were then randomly divided into two groups of intervention and control. In addition to the routine treatment, the intervention group was treated with 80-mg/day capsules of curcumin (nano-micelles). Further, the patients were followed up for three months, and clinical-laboratory examinations were recorded in this study. Results: There was no significant difference between the intervention and control groups regarding the trends of the disease activity indicators, including DAS-28, disability index, physician assessment, and the number of tender joints (P>0.05). Further, a significant difference was found between the two groups in terms of pain score changes and the number of swollen joints. Additionally, the curcumin-treated subjects obtained lower mean pain and fewer swollen joints, compared to those in the control group (P<0.05). Conclusion: The present study revealed that curcumin had no significant therapeutic effects on reducing the activity of RA; however, no significant side effects were observed on the patients, and it also showed its analgesic effect well. [ABSTRACT FROM AUTHOR]
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- 2023
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6. A double-blind placebo-controlled randomized trial of oral saffron in the treatment of rheumatoid arthritis
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Sahebari, Maryam, Heidari, Hossein, Nabavi, Shima, Khodashahi, Mandana, Rezaieyazdi, Zahra, Dadgarmoghaddam, Maliheh, Hosseinzaheh, Hossein, Abbasi, Shaghayegh, and Hashemzadeh, Kamila
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rheumatoid arthritis ,saffron ,clinical trial ,Original Research Article ,Therapeutics. Pharmacology ,RM1-950 ,Crocus sativus L. Iridaceae family ,crocus sativus l ,iridaceae family ,rct - Abstract
Objective: Recently, saffron (Crocus sativus L. from the Iridaceae family) has been characterized by its antioxidant, anti-inflammatory and analgesic effects. This study aimed to evaluate the effect of saffron on disease activity in patients with rheumatoid arthritis (RA). Materials and Methods: This is a double-blind, placebo-controlled, randomized clinical trial (RCT) performed on 55 newly- diagnosed RA patients without previous treatment, who were randomly divided into intervention (included 28 cases) and control groups (consisted of 27 individuals). Standard therapy including prednisolone, oral methotrexate, folic acid, vitamin D, calcium, and alendronate, was administered similarly in both groups. Patients received a 100 mg saffron pill/day (pure saffron powder) or placebo besides the standard protocol. The placebo had the same shape as the saffron pills. Follow up of DAS28ESR disease activity score was done on the 30th, 45th and 90th day of the study. Results: There was no difference between the intervention and control groups regarding to the DAS28ESR at the end of the study. However, a significant decrease in DAS28-ESR was observed in each group compared to the first visit (p=0.001). The results also showed no significant difference in the incidence of side effects in both groups. Conclusion: In summary, patients who received pure saffron pills (100 mg/day) in addition to standard therapy did not have a significant difference in improvement of disease activity from the patients on standard therapy.
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- 2021
7. Serum Trace Element Concentrations in Rheumatoid Arthritis
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Sahebari, Maryam, Ayati, Razie, Mirzaei, Hamed, Sahebkar, Amirhossein, Hejazi, Sepideh, Saghafi, Massoud, Saadati, Nayyereh, Ferns, Gordon A., and Ghayour-Mobarhan, Majid
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- 2016
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8. Morning melatonin serum values do not correlate with disease activity in rheumatoid arthritis: a cross-sectional study
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Afkhamizadeh, Mozhgan, Sahebari, Maryam, and Seyyed-Hoseini, Seyyed-Reza
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- 2014
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9. Frequency and Predictors of Opioid Use in Rheumatoid Arthritis and Seronegative Spondyloarthropathy Patients.
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Sahebari, Maryam, Ahmadi, Kourosh, Mehrad-Majd, Hassan, Karimani, Asieh, and Salari, Masoumeh
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RHEUMATOID arthritis , *CITY dwellers , *CONVENIENCE sampling (Statistics) , *LOGISTIC regression analysis , *OPIOID abuse , *OPIOIDS - Abstract
Background: Pain is one of the most challenging symptoms in patients with rheumatoid arthritis (RA) and spondyloarthropathies (SpAs), and pain relief is one of the top priorities for improving health-related quality of life. When medication therapy does not significantly reduce pain, chronic opioid consumption becomes more prominent in such patients. This study aimed to evaluate the state of opioid use in RA and SpA patients. Methods: This cross-sectional study was performed on 316 patients with RA and spondyloarthropathies (SpAs) from January to March 2014. The convenience sampling method was used to select the participants, and by obtaining verbal consent, everyone was given 15 minutes to complete a checklist independently. Demographic and opioid use data were evaluated in terms of opioid use and its predictors. In this regard, univariate and multivariate logistic regressions were used to evaluate the predictors of opioid consumption in patients. All analyses were conducted using SPSS 21 and the significance level was set at P < 0.05. Findings: About 9.5% of all participants, including 8.8% of RA and 22.6% of SpA cases, were opioid abusers. In the first step of the analysis, it was observed that opioid abuse was significantly higher in men, married participants, urban residents, patients with no biological therapy, and patients with a negative family history of addiction. The most prevalent ways of drug abuse were smoking and ingestion. The results of univariate logistic regression analysis revealed SpA and other factors significantly increase the chance of opioid abuse. Furthermore, multivariate logistic regression analysis showed male gender (OR = 10.4) and negative family history of addiction (OR = 3.19) significantly affected addiction in RA and SpA patients with a 95% confidence interval. Conclusion: Lack of suitable responsiveness to medication therapy to relieve pain, inconsistent pain evaluation, and shame of asking direct questions about addiction in RA and SpA patients may lead to opioid consumption in some cases. Seronegative SpA may make patients more prone to addiction. However, in this study, male gender and no family history of addiction were related to opioid abuse. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Skin inflammatory reactions to capsaicin in rheumatoid arthritis patients compared to healthy controls
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Salari, Masoumeh, Salari, Roshanak, Rafatpanah, Houshang, Ravanshad, Yalda, Zirachi, Danial, and Sahebari, Maryam
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Inflammation ,lcsh:Therapeutics. Pharmacology ,lcsh:RM1-950 ,Original Research Article ,Rheumatoid arthritis ,Capsaicin - Abstract
Objective: Previous studies have examined the role of sensory nerves and neural mediators in symmetrical joint inflammation and autoimmunity in rheumatoid arthritis (RA). In this study, we sought to examine the association between capsaicin skin test and disease activity in RA patients. Materials and Methods: Eighty RA patients (case group) and 20 healthy volunteers were enrolled in this experiment. The subjects in case group were calcified to newly diagnosed patients and those previously diagnosed with RA. A topical solution of capsaicin (0.075%) was applied on the volar forearm during the skin test, and evaluations were done after 5, 10, and 20 min. The parameters recorded in capsaicin skin test were time to tingling, area of induration (cm2), and area of redness (cm2). Results: A faster capsaicin skin reaction was observed in healthy controls compared to the case group (p=0.02). Newly diagnosed and previously diagnosed RA patients were not significantly different in terms of reaction latency (p=0.06). The redness area after 15 (p=0.04) and 20 (p=0.001) min was significantly larger in previously diagnosed RA patients than in newly diagnosed ones. The area of redness and time to tingling did not show any difference between active and inactive RA patients, but after 15 and 20 min, the area of redness was significantly greater in inactive RA patients compared to active RA patients (p=0.01 and p=0.03, respectively). Conclusion: This study suggested that capsaicin skin test is not an efficient tool for the examination of synovial inflammation and disease activity in RA.
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- 2019
11. Association between metabolic syndrome, BMI, and serum vitamin D concentrations in rheumatoid arthritis
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Goshayeshi, Ladan, Saber, HamidReza, Sahebari, Maryam, Rezaieyazdi, Zahra, Rafatpanah, Houshang, Esmaily, Habibollah, and Goshayeshi, Lena
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- 2012
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12. ABO and Rh blood groups in patients with lupus and rheumatoid arthritis.
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Nik, Amir, Mirfeizi, Zahra, Rezaieyazdi, Zahra, khodashahi, Mandana, Danevash, Shahin, Andalibi, Mohammad Sobhan Sheikh, Abbasi, Mahnaz, and Sahebari, Maryam
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RHEUMATOID arthritis ,AUTOIMMUNE diseases ,ANTIGENS ,ERYTHROCYTES ,ANEMIA - Abstract
Background: Systemic lupus erythematous (SLE) and rheumatoid arthritis (RA) are autoimmune diseases in which the antigen-antibody system plays an important role. As blood group and Rh are determined by the presence or absence of antigens on the surface of red blood cells (RBCs), we aimed to determine the distribution of ABO and Rh blood groups in SLE and RA patients and its association with disease manifestations. Methods: This short communication is based on a study that was conducted on 434 SLE and 828 RA patients. We evaluated the distribution of ABO and Rh blood groups in RA and SLE patients. Results: This study projected that in lupus patients, Coombs-positive autoimmune hemolytic anemia and arthritis were more common among the B blood type and Rh-positive group, respectively. Furthermore, there was no relation between ABO and Rh blood group and rheumatoid factor (RF) and anti-Cyclic Citrullinated Peptide (anti-CCP) seropositivity. Moreover, there was no difference in distribution of blood groups in RA and SLE patients. Conclusion: The higher frequency of blood group B in hemolytic anemia, and positive Rh in arthritis in lupus patients, develop the hypothesis of probable role of ABO blood group antigen in some manifestations of lupus. [ABSTRACT FROM AUTHOR]
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- 2021
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13. Serum hepcidin level and rheumatoid arthritis disease activity
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Sahebari, Maryam, Rezaieyazdi, Zahra, Hashemy, Seyed Isaac, Khorasani, Sahar, Shahgordi, Sanaz, Alizadeh, Mohammad Karim, Ghaeni, Abdolmomen, and Khodashahi, Mandana
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musculoskeletal diseases ,0301 basic medicine ,lcsh:Immunologic diseases. Allergy ,medicine.medical_specialty ,DAS28-ESR ,Gastroenterology ,03 medical and health sciences ,anemia of chronic disease ,Hepcidin ,Interquartile range ,Internal medicine ,medicine ,In patient ,Rheumatoid arthritis ,skin and connective tissue diseases ,030109 nutrition & dietetics ,medicine.diagnostic_test ,biology ,business.industry ,Significant difference ,medicine.disease ,anemia ,030104 developmental biology ,inflammation ,Erythrocyte sedimentation rate ,biology.protein ,Original Article ,hepcidin ,business ,lcsh:RC581-607 ,Rheumatoid arthritis disease activity ,Anemia of chronic disease - Abstract
Objective The present study aimed to determine the relationship between the serum hepcidin level and disease activity in patients with rheumatoid arthritis (RA). Methods This study was conducted on 80 patients with RA (36 cases with anemia of chronic disease [ACD] and 44 patients without ACD). Disease activity was measured by the 28-joint Disease Activity Score based on the erythrocyte sedimentation rate (DAS28-ESR). According to the DAS28-ESR score, 52 and 28 cases were categorized as inactive to moderately active RA (DAS28-ESR≤5.1) and highly active RA (DAS28-ESR>5.1), respectively. In addition, the serum hepcidin level was evaluated in all patients to determine its correlation with the DAS28-ESR score. Results There was no significant difference between the RA with ACD and RA without ACD groups in terms of the median (interquartile range) hepcidin level (1207 [985.2] vs. 923.8 [677.3] ng/mL; P=0.57). Likewise, no significant difference was observed between the active RA and inactive to moderately active RA groups in this regard (1131.8 [991.3] vs. 1090.9 [631.4] ng/mL; P=0.53). Conclusion Hepcidin has no association with disease activity in RA. Therefore, it is not necessary to measure hepcidin to determine the RA activity.
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- 2018
14. Comparison of Vitamin D Serum Values between Rheumatoid Arthritis and Lupus Populations: An Observational Study
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Ravanshad Yalda, Elham Atabati, and Sahebari Maryam
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0301 basic medicine ,medicine.medical_specialty ,Exacerbation ,Sun protection ,SLE ,Lupus ,Rheumatoid Arthritis ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Internal medicine ,VitD ,medicine ,Vitamin D and neurology ,In patient ,Vitamin D ,skin and connective tissue diseases ,030203 arthritis & rheumatology ,Proteinuria ,Systemic lupus erythematosus ,business.industry ,25(OH) D ,medicine.disease ,030104 developmental biology ,Rheumatoid arthritis ,Observational study ,medicine.symptom ,business ,RA - Abstract
Background:In recent years, the role of Vitamin D (VitD), as an immunomedulator in autoimmune diseases, has been evaluated in basic science and practice. There is a considerable volume of data on the effect of VitD position in lupus and rheumatoid arthritis exacerbation.Objective:This study aims to compare VitD serum values in lupus (SLE) and Rheumatoid Arthritis (RA) in the geographical region of northeastern Iran.Methods:Lupus and RA Patients were selected with various disease activity levels. All the patients received an equal amount of VitD supplementation and were selected by the same inclusion and exclusion criteria. VitD serum values were measured by a commercial ELISA kit. Data were analyzed in SPSS-15.Results:A total of 148 SLE and 156 RA patients were studied. VitD serum levels were 66.54±41.2 nmol/l in the SLE group and 83.74±46.45 nmol/l in the RA group. Statistical analysis showed that VitD serum levels were lower in lupus patients than RA ones (p=0.006).Conclusion:Since VitD deficiency is very common in Iran, physiologic doses of VitD supplementation in patients lead to higher serum levels of VitD. Lower VitD values in lupus patients compared with RA ones may stem from intestinal malabsorption, higher doses of corticosteroid therapy, renal involvement and proteinuria, different polymorphisms of VitD receptors, and more sun protection strategies in lupus patients.
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- 2017
15. A Study on Association Between Protein Carbonyl and Anti-cyclic Citrullinated Peptide Antibody in Rheumatoid Arthritis: Introducing a New Supplementary Biomarker.
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Khorasani, Sahar, Boroumand, Nadia, Ghaeni Pasavei, Abdolmomen, Sahebari, Maryam, and Hashemy, Seyed Isaac
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Redox state and immune mechanisms are two major factors implicated in rheumatoid arthritis (RA). Regarding some limitations of anti-cyclic citrullinated peptide (anti-CCP) antibody in RA diagnosis, recruiting another strong marker of oxidative stress could lead to more definitive diagnosis. To evaluate the potential of protein carbonyl content as a supplementary biomarker for RA. Eighty patients with RA attending the Research Center from 2015 to 2016 were recruited in this study. Smoker and alcoholic subjects, or those with any other systemic illness were excluded from the study. Demographic information and clinical data were collected. Numbers of swollen and tender joints were determined and RA disease activity was assessed. Serum samples were used for assessing protein carbonyl level, platelet count, and anti-CCP antibody values. Statistical analyses for significant differences were performed according to parametric (Student t test) and nonparametric (Mann–Whitney test) tests. The correlation was determined by Pearson coefficient. There was a significant correlation between protein carbonyl levels and anti-CCP antibodies in active RA (p value = 0.01), but not in remission phase (p value = 0.28). A significant positive correlation was observed between protein carbonyl levels and platelets count in active RA (p value = 0.001), but not in remission phase (p value = 0.85). Protein carbonyl could be considered as a future cost-effective supplementary biomarker, alongside anti-CCP antibody, in active RA diagnosis as it showed a significant positive correlation with anti-CCP antibody and platelet, two major mediators in the disease pathogenesis. [ABSTRACT FROM AUTHOR]
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- 2020
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16. Serum hepcidin level and rheumatoid arthritis disease activity.
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Sahebari, Maryam, Rezaieyazdi, Zahra, Hashemy, Seyed Isaac, Khorasani, Sahar, Shahgordi, Sanaz, Alizadeh, Mohammad Karim, Ghaeni, Abdolmomen, and Khodashahi, Mandana
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RHEUMATOID arthritis , *BLOOD sedimentation , *HEPCIDIN , *SERUM - Abstract
Objective: The present study aimed to determine the relationship between the serum hepcidin level and disease activity in patients with rheumatoid arthritis (RA). Methods: This study was conducted on 80 patients with RA (36 cases with anemia of chronic disease [ACD] and 44 patients without ACD). Disease activity was measured by the 28-joint Disease Activity Score based on the erythrocyte sedimentation rate (DAS28-ESR). According to the DAS28-ESR score, 52 and 28 cases were categorized as inactive to moderately active RA (DAS28-ESR=5.1) and highly active RA (DAS28-ESR>5.1), respectively. In addition, the serum hepcidin level was evaluated in all patients to determine its correlation with the DAS28-ESR score. Results: There was no significant difference between the RA with ACD and RA without ACD groups in terms of the median (interquartile range) hepcidin level (1207 [985.2] vs. 923.8 [677.3] ng/mL; P=0.57). Likewise, no significant difference was observed between the active RA and inactive to moderately active RA groups in this regard (1131.8 [991.3] vs. 1090.9 [631.4] ng/mL; P=0.53). Conclusion: Hepcidin has no association with disease activity in RA. Therefore, it is not necessary to measure hepcidin to determine the RA activity. [ABSTRACT FROM AUTHOR]
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- 2019
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17. Additional effect of etanercept or infliximab on the liver function tests of patients with rheumatoid arthritis: a cohort study.
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Akhlaghi, Saeed, Sahebari, Maryam, Mahmoodi, Mahmoud, Yaseri, Mehdi, Mansournia, Mohammad Ali, Rafatpanah, Houshang, and Zeraati, Hojjat
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ETANERCEPT , *INFLIXIMAB , *LIVER function tests , *RHEUMATOID arthritis , *METHOTREXATE , *ALANINE aminotransferase - Abstract
Purpose: One of the most important long-term side effects of therapy for rheumatoid arthritis (RA) is the elevation of liver function tests, with earlier studies reporting an elevation of more than 1× the upper limit of normal (>1 × ULN). The current study expands the literature by comparing the trends of transaminase changes caused by conventional and biologic disease-modifying antirheumatic drugs (DMARDs).Patients and Methods: The drug categories examined were methotrexate (MTX) and all other nonbiologic DMARDs. Where RA patients exhibited inadequate response to conventional DMARDs (cDMARDs), we added biologic DMARDs (bDMARDs) to the treatment. We compared the trend of changes in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the patients receiving MTX with the trend observed in the patients whose treatment encompassed both bDMARDs and MTX. The comparison was conducted using random intercept models, which are a type of linear mixed effects model.Results: This work involved 512 RA patients (MTX: 450, MTX + infliximab [INF]: 26, MTX + etanercept [ETA]: 36), whose ALT and/or AST levels were measured in 1,786 visits (MTX: 1,543, MTX + INF: 107, MTX + ETA: 136). ALT and/or AST elevations greater than 1 × ULN were observed in 344 (19.3%) visits (MTX: 295 [19.1%], MTX + INF/ETA: 49 [20.2%]). In this study, the trends of ALT and AST changes increased when receiving MTX, while the INF/ETA addition decreased these trends. The random intercept models indicated that changes in the mean ALT levels were significantly different over the time for MTX and MTX + INF/ETA groups (β [SE] =-0.190 [0.093], P= 0.040) but changes in the mean AST levels were nonsignificantly different over the time for such groups (β [SE] =-0.099 [0.064], P=0.120).Conclusion: Despite a higher incidence of elevated transaminases during the use of MTX + INF/ETA, the combination of INF/ETA with MTX reduced transaminase levels and returned ALT levels to normal concentrations. [ABSTRACT FROM AUTHOR]- Published
- 2018
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18. Association between metabolic syndrome (MetS) and serum Vitamin D concentrations in rheumatoid arthritis
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Sahebari Maryam, Mirfeizi Zahra, Saber Hamidreza, Ghayour Mobarhan Majid, Rezaiyeyazdi Zahra, and Goshayeshi Ladan
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Serum vitamin ,medicine.medical_specialty ,Endocrinology ,business.industry ,Internal medicine ,Rheumatoid arthritis ,Clinical Biochemistry ,Medicine ,General Medicine ,Metabolic syndrome ,business ,medicine.disease - Published
- 2011
19. Relationship between cartilage oligomeric matrix protein (COMP) and rheumatoid arthritis severity.
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Saghafi, Massoud, Khodashahi, Mandana, Saadati, Nayyereh, Azarian, Azita, Rezaieyazdi, Zahra, Salehi, Maryam, and Sahebari, Maryam
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AUTOANTIBODY analysis , *HAND radiography , *KNEE radiography , *GLYCOPROTEIN analysis , *BLOOD sedimentation , *C-reactive protein , *CARTILAGE , *STATISTICAL correlation , *ENZYME-linked immunosorbent assay , *GLYCOPROTEINS , *RESEARCH funding , *RHEUMATOID arthritis , *PREDICTIVE tests , *CROSS-sectional method , *SEVERITY of illness index , *RECEIVER operating characteristic curves , *DATA analysis software , *DESCRIPTIVE statistics , *ONE-way analysis of variance - Abstract
Background: Serum cartilage oligomeric matrix protein (COMP) is a non-collagen glycoprotein produced by the cartilage, synovium, tendon, and meniscus. Recent studies showed that COMP is a reliable factor for monitoring cartilage damage. Objective: To determine the relationship between serum COMP concentration and the severity of rheumatoid arthritis (RA). Methods: This cross-sectional study lasted from 2013 to 2015 at the Rheumatology Clinic of Ghaem Hospital, Mashhad, Iran. The study population consisted of eligible patients who presented to our clinic during the study period. Four groups (150 subjects) were included as early RA (50 patients), late RA (50 patients), grades II and III OA (osteoarthritis) (25 cases, 17 grade II and 8 grade III joint destruction), and healthy controls (25 individuals). These were included consecutively. Serum COMP level was assessed by sandwich ELISA technique. In addition, ESR, hs-CRP, serum RF, and anti-CCP were assayed. X-rays of the knees (in OA) and hands (in RA) were examined for the degree of joint damage/erosion using the Short Erosion Scale (SES) in RA and Kellgren-Lawrence grading in OA. Analysis of variance (ANOVA) to compare mean COMP level among the groups and ROC (Receiver Operating Characteristic) analysis to determine the diagnostic accuracy of COMP in diagnosis of late RA were used by SPSS software (ver. 20.0). Results: Mean (±SD) serum COMP levels were 18 (±10.6) U/L in early RA, 19.3 (±9.6) U/L in late RA, 10.9 (±4.5) U/L in OA, and 4.2 (±3.8) in controls; p<0.001. Serum COMP level was higher in RA and OA groups when compared to control group. Mean (±SD) SES score was 13.5 (±7.5) in early RA and 16.4 (±9.7) in late RA (p=0.093). There was a significant positive correlation between COMP level and disease severity in early RA (r=0.677, p<0.001) as well as in late RA (r=0.753, p<0.001). Serum COMP level at a concentration of 15.25 U/L had a sensitivity of 68% and specificity of 70% to discriminate late RA from early RA (area under curve= 69% (95% CI: 58% to 79%; p=0.001). Conclusion: COMP had positive significant correlation with early and late RA severity. This serum biomarker can be a useful and easy tool for monitoring of RA patients either at early or late stages of the disease. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
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