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Your search keyword '"Yu, Shaoqing"' showing total 9 results
Start Over Author "Yu, Shaoqing" Topic rhinitis, allergic, perennial
9 results on '"Yu, Shaoqing"'

1. [Early compliance and efficacy of sublingual immunotherapy in patients with allergic rhinitis].

Author

Li G, Zhu C, Chen J, Yu S, Lin J, Wang B, Ye B, Zhang S, Zhao X, Zhang T, and He Z

Subjects
Adolescent, Adult, Aged, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Patient Satisfaction, Rhinitis, Allergic, Treatment Outcome, Young Adult, Patient Compliance, Rhinitis, Allergic, Perennial psychology, Rhinitis, Allergic, Perennial therapy, Sublingual Immunotherapy psychology
Abstract

Objective: The study aimed to investigate the efficacy and adverse effects of sublingual immunotherapy (SLIT) of dust mite drops to allergic rhinitis with mite allergy. The compliance and satisfaction of SLIT were also assessed., Method: One hundred and three patients of allergic rhinitis sensitive to dust mites were treated with SLIT for 6 months or more. The symptom questionnaire,including items on rhinorrhea, sneezing, nasal obstruction, itchy nose, olfactory disturbance, eye discomfort and sleep disturbance were obtained before and 6 months after SLIT. The patients' satisfaction and adverse effects were also investigated., Result: Seventy-five of the 103 patients insist on SLIT for more than 6 months and completed the questionnaire. The duration of receiving SLIT was 9.8 months on average (range from 6 to 13 months). The satisfaction rate was 89.3%. The drop-out rate of SLIT was 31.0%., Conclusion: The subjective symptoms were improved with SLIT in patients with allergic rhinitis sensitive to dust mites. The drop out rate was high despite of the symptomatic improvement.

Published
2013

2. [Content of CD4+ CD25+ regulatory T cells in peripheral blood lymphocytes in patients with allergic rhinitis].

Author

Yu S, Chen Y, Zhang J, Yan Z, and Zhang R

Subjects
Adult, Case-Control Studies, Female, Flow Cytometry, Humans, Interleukin-2 Receptor alpha Subunit immunology, Interleukin-2 Receptor alpha Subunit metabolism, Male, Middle Aged, Rhinitis, Allergic, Perennial immunology, T-Lymphocytes, Regulatory immunology, Young Adult, Rhinitis, Allergic, Perennial blood, T-Lymphocytes, Regulatory metabolism
Abstract

Objective: To investigate the change of CD4- CD25 regulatory T cells (Tregs) of peripheral blood in allergic rhinitis (AR) patients., Method: T lymphocytes of twenty AR patients and eight healthy subjects were separated and the flow cytometry was used to measure the percentage of CD4+ CD25+ Treg., Result: Compared with control group, the percentage of Treg and CD4- CD25high Tregs of AR patients was decreased significantly (P < 0.05)., Conclusion: The proportion of CD4+ CD25+ Tregs decreased in AR patients conspicuously, which might be one of the pathogenesis of AR.

Published
2011

3. [Different expression of histamine H4 receptor in nasal mucosa in allergic rhinitis patients].

Author

Yan Z, Zhang J, Li D, Yu S, Gao S, Shao X, and Hong J

Subjects
Case-Control Studies, Humans, Nasal Mucosa immunology, Nasal Mucosa pathology, Receptors, Histamine H4, Rhinitis, Allergic, Perennial immunology, Rhinitis, Allergic, Perennial pathology, Nasal Mucosa metabolism, Receptors, G-Protein-Coupled metabolism, Receptors, Histamine metabolism, Rhinitis, Allergic, Perennial metabolism
Abstract

Objective: To observe expression and distribution of histamine H4 receptor in nasal mucosa in normal people and allergic rhinitis patients,and understand role of histamine H4 receptor in allergic rhinitis., Method: Select normal people and allergic rhinitis patients each 10, take the nasal mucosa, detect expression and distribution of histamine H4 receptor at proteins and transcription level respectively by immunohistochemical method and RT-PCR, and compared., Result: Histamine H4 receptor at proteins and transcription level were found in normal nasal mucosa (25 509 +/- 6 441, 0.42 +/- 0.08), increased significantly in nasal mucosa of allergic rhinitis patients (49 676 +/- 8 541, 0.69 +/- 0.11, P < 0.05), which in structural cells and immune cells., Conclusion: Histamine H4 receptors exist in normal nasal mucosa, its express significantly enhance, flew histamine H4 receptor may be mediated histamine in pathogenesis of allergic rhinitis ,who is one of the ligands of histamine.

Published
2010

4. [Study on the expression of Eotaxin and the role of histamine in allergic rhinitis].

Author

Yan Z, Zhang R, Yu S, and Wu G

Subjects
Animals, Chemokine CCL11 biosynthesis, Female, Male, Nasal Mucosa metabolism, Rats, Rats, Sprague-Dawley, Rhinitis, Allergic, Perennial pathology, Rhinitis, Allergic, Seasonal pathology, Chemokine CCL11 metabolism, Histamine metabolism, Rhinitis, Allergic, Perennial metabolism, Rhinitis, Allergic, Seasonal metabolism
Abstract

Objective: To explore the expression of Eotaxin and the effect of histamine in allergic rhinitis model (AR), and aim to explore the pathogenesis of AR., Method: The AR models were established by application of ovum albumin in rats. The expression of Eotaxin in nasal mucosa, serum and nasal cavity lavage fluid, were observed before and after treatment of histamine or its antagonist by immunochemistry, RT-PCR and ELISA technique., Result: The expression of Eotaxin in nasal lavage fluid and nasal mucosa increased after treatment of histamine (P < 0.05). Contrarily, the expression of Eotaxin in nasal lavage fluid, nasal mucosa and serum decreased after treatment of the antagonist of histamine., Conclusion: Both histamine and its receptor can involve in the pathogenesis of AR by affecting the expression of Eotaxin.

Published
2009

5. [The expression and DNA sequence of recombination activating gene-1 in nasal membrane of allergic rhinitis].

Author

Zhang R, Wu G, Wen W, Liu G, Yan Z, Yu S, and Sun W

Subjects
Animals, Female, Gene Expression, Immunoglobulin E immunology, Interleukin-10 immunology, Interleukin-4 immunology, Male, Nasal Mucosa immunology, Rats, Rats, Sprague-Dawley, Rhinitis, Allergic, Perennial immunology, Sequence Analysis, DNA, Homeodomain Proteins genetics, Nasal Mucosa metabolism, Rhinitis, Allergic, Perennial genetics, Rhinitis, Allergic, Perennial metabolism
Abstract

Objective: To study the mechanism of recombination activating gene-1 in pathogenesis of allergic rhinitis and its relation to interleukin-4 (IL-4), interleukin-10 (IL-10) and immunoglobin E (IgE)., Method: Three groups of allergic rats models were established with ovalbumin (OVA) and intervened with Dexamethasone (DEX). The times of sneeze were recorded, the cutaneous reaction of rats to the passive cutaneous allergen access (PCA) were investigated and the expression and DNA sequence of recombination activating gene-1 were examined and tested with reverse transcription-polymerase chain reaction (RT-PCR) and DNA analysator. The serum levels of IL-4, IL-10 and IgE were examined and tested with enzyme linked immunosorbent assay (ELISA) method in comparison with the controls., Result: RAG-1 mRNA expression was not found in normal nasal membrane. Both in AR group and DEX intervention group were seen different expressions; DNA sequence determination didn't find mutation of RG1 genes. The serum level of IL-4[(106.31 +/- 12.90) ng/L] and IgE[(38.67 +/- 4.13) ng/L] in AR group were significantly higher than those in normal control [(93.65 +/- 7.78) ng/L, (23.27 +/- 1.36) ng/L respectively] (P < 0.05), but the IL-10 level [(38.15 +/- 4.89) ng/L] in AR group was significantly lower than those in normal control [(48.74 +/- 3.49) ng/L] (P < 0.05). After DEX intervention, the serum level of IL-4[(92.67 +/- 16.40) ng/L] and IgE[(24.23 +/- 4.38) ng/L] significantly dropped as compared with AR group (P < 0.05) while IL-10[(46.18 +/- 5.01) ng/L] significantly rose (P < 0.05)., Conclusion: It proves that the high expression of recombination activating genes is closely related to the pathogenesis of allergic rhinitis, which leads to the secretion of IL-4 and inhibits that of IL-10 and whose sequence is conservative in the nasal mucosa of AR. As glucocorticoid does not affect the expression of RAG-1 genes, it suggests that RAG-1 may be an immunomodulator on a higher level in the pathogenesis of AR.

Published
2006

6. [Experiment of genes expression of chemokines and their receptors in allergic rhinitis with gene chip].

Author

Yu S, Zhang R, Liu G, Wen W, and Shen X

Subjects
Adult, Female, Gene Expression, Humans, Male, Middle Aged, Nasal Mucosa metabolism, Oligonucleotide Array Sequence Analysis, Rhinitis, Allergic, Perennial etiology, Chemokines, CC genetics, Receptors, Chemokine genetics, Rhinitis, Allergic, Perennial genetics
Abstract

Objective: To analyze the role of chemokines and their receptors in the mechanism of allergic rhinitis (AR) by observing the expression of genes of chemokines and their receptors in nasal mucosa of AR through gene chip., Method: The total RNAs were isolated from nasal mucosa of AR and purified to mRNAs, then reversely transcribed to cDNAs and incorporated with fluorescent-labled CY5-dUPT for probes preparion. CY3-dUTP probes prepared with normal nasal mucosa of normal for control. The chip contains cDNAs of chemokines and their receptors were used to hybridized with probes then screened with computer to study the expression of genes based on different density of fluorescent., Result: The chemokines of CCL11 (eotaxin-1), CCL24 (eotaxin-2), CCL7 (MCP-3), CCL13 (MCP-4), RANTES (CCL5) and receptors of CCR2, CCR3, CCR4, CCR5 were differential expressed on four samples, and most of the chemokines and their receptors has tendency regulation on T help 2 (Th2) lymphocytes and involved in the prodeeds such as inducement of allergic reaction,accumulation of inflammacytes and degranulation of sensitized cells., Conclusion: A disorder exists in T helper immune system with AR. The chemokines and their receptors that polarized with Th2 lymphocytes perhaps play important roles in AR pathogenesis, and it represents a new approach to AR immunotherapy.

Published
2005

7. [Gene chip screen in allergic rhinitis and preliminary analysis of the differential expressed genes].

Author

Zhang R, Yu S, Ying K, Xie Y, Li D, Ni X, Wen W, Shen X, and Mao Y

Subjects
DNA, Complementary, Genetic Variation, Humans, Gene Expression Profiling, Oligonucleotide Array Sequence Analysis, Rhinitis, Allergic, Perennial genetics
Abstract

Objective: To discover the etiology of allergic rhinitis(AR) at the genomic level., Methods: Microarray analysis on a genomic scale was used to find changes in genes expression in AR. The total RNAs were isolated from nasal mucosa of AR and normal, then purified to mRNAs and were reversely transcribed to cDNAs with the incorporation of fluorescent-labeled dUTP to prepare for the hybridization probes. The genes differential expressed in AR were screened with the gene chip which contained 12,800 human genes in all 8 samples., Result: 734 genes were shown in differential expressed profile with 430 upregulated genes and 304 downregulated genes, and all 8 samples were 15 genes upregulated and 6 genes downregulated. The differential expressed genes involved in the functions of inflammation, immunology, neuroendocrine and signal conduct, and they had potential value in AR study., Conclusion: The investigation based on gene chip in researching related genes in AR afforded a new idea in studying pathogenesis of nasal allergic diseases.

Published
2002

8. Microarray analysis of differentially expressed microRNAs in allergic rhinitis

Author

Zhang Jie, Zhang Ruxin, Hu Hua, Yu Shudong, Liu Guojun, Yan Zhiqiang, and Yu Shaoqing

Subjects
Adult, Male, Rhinitis, Allergic, Perennial, Common disease, Genome-wide association study, Mucous membrane of nose, Inflammation, Bioinformatics, microRNA, medicine, Immunology and Allergy, Humans, Regulation of gene expression, Mechanism (biology), Microarray analysis techniques, business.industry, General Medicine, Allergens, Immunoglobulin E, Middle Aged, Microarray Analysis, body regions, MicroRNAs, Nasal Mucosa, Otorhinolaryngology, Gene Expression Regulation, embryonic structures, Immunology, Pollen, Female, medicine.symptom, Nasal Obstruction, business, Genome-Wide Association Study
Abstract

Background Allergic rhinitis (AR) is a common disease characterized by chronic inflammation of the nasal mucosa, but we have not fully understood the mechanism responsible for the development of AR. MicroRNAs (miRNAs) are short endogenous noncoding RNAs regulating protein translation through a mechanism known as RNA interference. To understand the molecular mechanisms of miRNA involved in the pathogenesis of AR, expressed miRNAs in AR were investigated through genomewide microarray analysis. Methods Mammalian miRNA microarrays containing whole human mature and precursor miRNA sequences were used for analyzing eight samples of nasal mucosa of AR and eight samples of nonallergic patients. Quantitative reverse transcriptase–polymerase chain reaction (RT-PCR) of some different expressed miRNAs was used to confirm the array results. Results The miRNA microarray chip analysis identified 421 miRNAs differentially expressed in the nasal mucosa of AR, and a total of 9 miRNAs were identified in the AR group with twofold change compared with control samples (p < 0.05). These included up-regulated miRNAs, hsa-hsa-miR-7, and hsa-miRPlus-E1194, and down-regulated miRNAs, hsa-miR-498, hsa-miR-187, hsa-miR-874, hsa-miR-143, hsa-miR-886–3p, hsa-miR-224, and hsa-miR-767–5p. RT-PCR results also confirmed that part of differentially expressed miRNAs as hsa-miR-224, hsa-miR-187, and hsa-miR-143 were down-regulated in AR. Conclusion The report indicated that many miRNA expressions were altered in AR and differentially expressed miRNAs appear to be involved in the development of AR. The study of miRNAs may lead to a better understanding about the roles of identified miRNAs in the pathogenesis of AR; this would be considered in future therapeutic strategies.

Published
2011

9. A meta-analysis of the association of exhaled carbon monoxide on asthma and allergic rhinitis

Author

Li Genhong, Wang Yanshen, Zhang Ruxin, Chen Yingjian, Yu Shaoqing, and Chen Jianqiu

Subjects
Adult, medicine.medical_specialty, Allergy, Rhinitis, Allergic, Perennial, Exacerbation, Adolescent, medicine.drug_class, law.invention, Randomized controlled trial, law, Adrenal Cortex Hormones, Internal medicine, Immunology and Allergy, Medicine, Humans, Child, Asthma, Randomized Controlled Trials as Topic, Carbon Monoxide, National Library of Medicine (U.S.), business.industry, Respiration, General Medicine, Middle Aged, medicine.disease, Confidence interval, United States, Nasal Mucosa, Breath Tests, Strictly standardized mean difference, Exhalation, Meta-analysis, Physical therapy, Corticosteroid, business, Biomarkers, Heme Oxygenase-1
Abstract

The objective of this study is to evaluate the effect of exhaled CO (eCO) on the development of asthma and allergic rhinitis (AR) by means of reviewing published literature. The literatures published between January 1997 and December 2008 from the US National Library of Medicine (NLM) Database were obtained according to inclusion criteria. Meta-analysis of randomized controlled trials (RCTs) was performed. CO levels of asthma and AR patients were compared with that of normal controls. HO-1(heme oxygenase-1) expression and effect of corticosteroids on eCO levels were also analyzed. Fifteen studies concerning asthma and four studies concerning AR were included in this analysis. Heterogeneity from different studies was evident (P < 0.0001), so a random-effects model was preferred. The meta-analysis revealed that asthmatic patients had significantly higher levels of eCO compared to normal controls. There was significant difference between asthma and control groups in terms of eCO (combined weighted mean difference (WMD) 1.33 (95% confidence interval 0.72 to 1.95), P < 0.0001), and no significant difference between AR and control (combined WMD 0.93 (95% confidence interval −0.54 to 2.40), P = 0.22). HO-1 expression were also reviewed, asthma group produced greater expression of HO-1 than control group with significant difference (combined standardized mean difference (SMD) 2.98 (95% confidence interval 1.13 to 4.84), P = 0.002). After corticosteroid therapy, significantly different levels of eCO were produced after corticosteroid therapy than did asthma group (combined WMD −1.23 (95% confidence interval −2.43 to −0.03), P = 0.04). The analysis reveals that eCO levels were significantly raised in asthma and it may attribute to high expression of HO-1, but there were no significantly high eCO levels between AR and control groups. Due to sensitivity to corticosteroid inhibition, eCO may be used as a practical marker to detect and monitor exacerbation of asthma.

Published
2010

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