1. Establishing a model of seasonal allergic rhinitis and demonstrating dose-response to a topical glucocorticosteroid.
- Author
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Ahlström-Emanuelsson C, Persson CG, Svensson C, Andersson M, Hosszu Z, Akerlund A, and Greiff L
- Subjects
- Administration, Topical, Adult, Anti-Allergic Agents administration & dosage, Anti-Inflammatory Agents administration & dosage, Budesonide administration & dosage, Cross-Over Studies, Dose-Response Relationship, Drug, Double-Blind Method, Female, Glucocorticoids, Humans, Male, Mometasone Furoate, Nasal Provocation Tests, Pregnadienediols administration & dosage, Rhinitis, Allergic, Seasonal diagnosis, Anti-Allergic Agents therapeutic use, Anti-Inflammatory Agents therapeutic use, Budesonide therapeutic use, Models, Immunological, Pregnadienediols therapeutic use, Rhinitis, Allergic, Seasonal drug therapy
- Abstract
Background: Symptoms of seasonal allergic rhinitis may vary greatly. Hence, for research purposes, there is a need for disease-like models of allergic rhinitis. In a preliminary study, involving 7 days' challenge with allergen, promising symptom consistency was obtained and dose-response to a glucocorticosteroid could, in part, be demonstrated., Objective: To establish this model of seasonal allergic rhinitis and test the hypothesis that mometasone furoate is more potent than budesonide as an antirhinitis drug., Methods: Thirty-eight patients with seasonal allergic rhinitis received treatment with spray-formulations of placebo, budesonide 64 microg, budesonide 256 microg, and mometasone furoate 200 microg in a double-blind, crossover design. After 3 days' treatment, individualized nasal allergen-challenges were administered daily for 7 days while the treatment continued. Nasal symptoms and peak inspiratory flow (PIF) were recorded., Results: During the last 3 days of allergen challenge without active treatment, consistent around-the-clock symptoms were recorded and recordings during these days were used in the analysis. With few exceptions the active treatments reduced nasal symptoms and improved nasal PIF (P values <0.001 to 0.05). Budesonide caused dose-dependent improvements in evening symptoms, morning nasal PIF, and nasal PIF recorded 10 minutes after allergen-challenge (P values <0.05). Budesonide 256 microg produced greater improvement than mometasone furoate 200 microg for nasal PIF 10 minutes after allergen-challenge (P < 0.05)., Conclusion: The present allergen challenge method, producing consistent symptoms and nasal PIF data, emerges as a model of seasonal allergic rhinitis well suited for exploring potency and efficacy of drug intervention. The present data do not support the view that mometasone furoate is a more potent antirhinitis drug than budesonide.
- Published
- 2002
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