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Your search keyword '"Dion RL"' showing total 4 results
Start Over Author "Dion RL" Topic ribonucleosides
4 results on '"Dion RL"'

1. Mechanism of resistance to the oncolytic C-nucleoside 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC-286193).

Author

Jayaram HN, Cooney DA, Glazer RI, Dion RL, and Johns DG

Subjects
Animals, Antineoplastic Agents metabolism, Drug Resistance, Guanosine Triphosphate metabolism, Leukemia P388 metabolism, Mice, Neoplasm Transplantation, Ribavirin analogs & derivatives, Ribavirin metabolism, Time Factors, Antineoplastic Agents pharmacology, Leukemia P388 drug therapy, Leukemia, Experimental drug therapy, Ribavirin pharmacology, Ribonucleosides pharmacology
Published
1982
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2. Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC 286193).

Author

Jayaram HN, Dion RL, Glazer RI, Johns DG, Robins RK, Srivastava PC, and Cooney DA

Subjects
Animals, Cell Division drug effects, Cell Survival drug effects, DNA, Neoplasm biosynthesis, Hypoxanthines metabolism, IMP Dehydrogenase metabolism, Leukemia L1210 drug therapy, Leukemia P388 drug therapy, Ligases metabolism, Mice, Ribavirin analogs & derivatives, Structure-Activity Relationship, Antineoplastic Agents pharmacology, Carbon-Nitrogen Ligases, Ribavirin pharmacology, Ribonucleosides pharmacology
Published
1982
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3. Conversion of 2-beta-D-ribofuranosylselenazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties.

Author

Jayaram HN, Ahluwalia GS, Dion RL, Gebeyehu G, Marquez VE, Kelley JA, Robins RK, Cooney DA, and Johns DG

Subjects
Animals, Gas Chromatography-Mass Spectrometry, Mice, Selenium chemical synthesis, IMP Dehydrogenase antagonists & inhibitors, Ketone Oxidoreductases antagonists & inhibitors, Leukemia P388 drug therapy, Leukemia, Experimental drug therapy, NAD analogs & derivatives, Organoselenium Compounds, Ribavirin analogs & derivatives, Ribavirin toxicity, Ribonucleosides chemical synthesis, Ribonucleosides toxicity, Selenium toxicity
Published
1983
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4. Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogues. Synthesis, structure, and interactions with IMP dehydrogenase.

Author

Gebeyehu G, Marquez VE, Van Cott A, Cooney DA, Kelley JA, Jayaram HN, Ahluwalia GS, Dion RL, Wilson YA, and Johns DG

Subjects
Animals, Kinetics, Leukemia P388 enzymology, Mice, Ribavirin analogs & derivatives, Ribavirin metabolism, Ribonucleosides metabolism, Selenium metabolism, IMP Dehydrogenase metabolism, Ketone Oxidoreductases metabolism, NAD analogs & derivatives, Organoselenium Compounds, Ribavirin chemical synthesis, Ribonucleosides chemical synthesis, Selenium chemical synthesis
Abstract

A series of dinucleotides, analogous to nicotinamide adenine dinucleotide but containing the five-membered base nucleosides tiazofurin (1a), selenazofurin (1b), ribavirin (2), and AICAR (3) in place of nicotinamide ribonucleoside, were prepared in greater than 50% yield by reacting the corresponding nucleotide imidazolidates (6a-d) with adenosine 5'-monophosphate (AMP). The symmetric dinucleotides of tiazofurin (TTD, 8e) and selenazofurin (SSD, 8f) were also prepared by a similar methodology. These dinucleotides were characterized by 1H NMR and fast atom bombardment MS and were evaluated for their inhibitory potency against a partially purified preparation of tumoral inosine monophosphate dehydrogenase (IMPD) from P388 cells. The order of potency found was SAD (8b) greater than TAD (8a) much greater than SSD (8f) congruent to TTD (8e) congruent to RAD (8c) much much greater than ZAD (8d). On kinetic analysis none of the dinucleotides produced competitive inhibition of IMPD with NAD as a variable substrate. In addition to their superior IMPD inhibitory activity, SAD and TAD appear to be the only dinucleotides, besides NAD, that are formed naturally by the NAD pyrophosphorylase from P388 lymphoblasts.

Published
1985
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