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Your search keyword '"Alkylation -- Physiological aspects"' showing total 14 results
Start Over Descriptor "Alkylation -- Physiological aspects" Topic ring formation (chemistry) -- physiological aspects
14 results on '"Alkylation -- Physiological aspects"'

1. An efficient synthesis of novel carbocyclic nucleosides with use of ring-closing metathesis from D-lactose

Author

Joon Hee Hong, Myung Jung Shim, Bong Oh Ro, and Ok Hyun Ko

Subjects
Chemistry, Organic -- Research, Carbon -- Physiological aspects, Cyclic compounds -- Physiological aspects, Nucleosides -- Physiological aspects, Ring formation (Chemistry) -- Physiological aspects, Lactose -- Physiological aspects, Alkylation -- Physiological aspects, Stereochemistry -- Research, Biological sciences, Chemistry
Abstract

Research has been conducted on the carbocyclic nucleosides. The synthetic route to these nucleosides has been developed and the results indicate that the targeted nucleosides' stereochemistry has been obtained via the use of Grubbs cyclization and Trost allylic alkylation from D-lactose.

Published
2002

2. Facile synthesis of plasmalogens via Barbier-type reactions of vinyl dioxanes and vinyl dioxolanes with alkyl halides in LiDBB solution

Author

Shin, Junhwa, Gerasimov, Oleg, and Thomson, David H.

Subjects
Chemistry, Organic -- Research, Solution (Chemistry) -- Physiological aspects, Halides -- Physiological aspects, Lithium -- Physiological aspects, Chemical reactions -- Analysis, Alkylation -- Physiological aspects, Dioxane -- Physiological aspects, Ring formation (Chemistry) -- Physiological aspects, Choline -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the plasmalogens, a class of glycerophospholipids difficult to synthesize. The method for the preparation of the racemic plasmenylcholines via the reductive vinyl dioxane/dioxolane ring opening has been developed and is described.

Published
2002

3. Cyclization of 1-(2-alkynylphenyl)-3,3-dialkyltriazenes: a convenient, high-yield synthesis of substituted cinnolines and isoindazoles

Author

Kimball, David B., Weakley, Timothy J. R., and Haley, Michael M.

Subjects
Chemistry, Organic -- Research, Ring formation (Chemistry) -- Physiological aspects, Alkylation -- Physiological aspects, Substitution reactions -- Analysis, Biological sciences, Chemistry
Abstract

Research has been conducted on isoindazoles and cinnolines. The route to these compounds developed via the cyclization of (2-alkynylphenyl)triazenes under neutral conditions is described and the results indicate that the reaction products depend on the temperature and the type of alkyne ortho to triazene functionality.

Published
2002

4. 1,2-silyl-migrative cyclization of vinylsilanes bearing a hydroxy group: stereoselective synthesis of multisubstituted tetrahydropyrans and tetrahydrofurans

Author

Miura, Katsukiyo, Hondo, Takeshi, Okajima, Shigeo, Nakagawa, Takahiro, Takahashi, Tatsuyuki, and Hosomi, Akira

Subjects
Chemistry, Organic -- Research, Ring formation (Chemistry) -- Physiological aspects, Silane -- Physiological aspects, Stereochemistry -- Research, Hydrogen -- Physiological aspects, Furans -- Physiological aspects, Alkylation -- Physiological aspects, Acids -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the triorganosilyl groups. The results of the acid-catalyzed intramolecular addition of the hydroxy group to alpha-alkylated vinylsilanes are reported.

Published
2002

5. A new methodology for synthesis of a chiral phosphinocarboxylic acid through Michael cyclization-aldol tandem reaction of chiral alpha,beta,chi,psi-unsaturated bisphosphine oxide and application in palladium-catalyzed asymmetric allylic alkylation

Author

Inoue, Hideki, Nagaoka, Yasuo, and Tomioka, Kiyoshi

Subjects
Chemistry, Organic -- Research, Ring formation (Chemistry) -- Physiological aspects, Carboxylic acids -- Physiological aspects, Phosphorus -- Physiological aspects, Chemical reactions -- Analysis, Oxides -- Physiological aspects, Palladium catalysts -- Physiological aspects, Alkylation -- Physiological aspects, Lithium -- Physiological aspects, Chirality -- Physiological aspects, Amides -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the chiral alpha,beta,psi,omega-unsaturated bisphosphine oxide. Results indicate that after the treatment with lithium diisopropylamide and benzaldehyde this compound underwent Michael cyclization-aldol tandem reaction in producing endo-alpha,beta-unsaturated bisphosphine oxides.

Published
2002

6. Chiral nonracemic alpha-alkylidene and alpha-silylidene cyclopentenones from chiral allenes using an intramolecular allenic Pauson-Khand-type cycloaddition

Author

Brummond, Kay M., Kerekes, Angela D., and Wan, Honghe

Subjects
Chemistry, Organic -- Research, Chirality -- Physiological aspects, Alkylation -- Physiological aspects, Ring formation (Chemistry) -- Physiological aspects, Cyclic compounds -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the chiral nonracemic allene. The study of the chirality transfer from this allene to the alpha-silylidene and alpha-alkylidene cyclopentenones is presented.

Published
2002

7. Lewis acid-activated chiral leaving group: enantioselective electrophilic addition to prochiral olefins

Author

Nakamura, Hiroko, Ishihara, Kazuaki, and Yamamoto, Hisashi

Subjects
Chemistry, Organic -- Research, Acids -- Physiological aspects, Chirality -- Physiological aspects, Enantiomers -- Physiological aspects, Olefins -- Physiological aspects, Ring formation (Chemistry) -- Physiological aspects, Alkylation -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the prochiral olefins. The strategy developed for the enantioselective alkylation of these olefins using a chiral leaving group and Lewis acid is described.

Published
2002

8. Syntheses of C12,N13 heterocyclic bridged fused indenopyrrolocarbazoles

Author

Underiner, Ted L., Mallamo, John P., and Singh, Jasbir

Subjects
Chemistry, Organic -- Research, Heterocyclic compounds -- Physiological aspects, Alkylation -- Physiological aspects, Carbon -- Physiological aspects, Solution (Chemistry) -- Physiological aspects, Solid state chemistry -- Physiological aspects, Ring formation (Chemistry) -- Physiological aspects, Chemical inhibitors -- Physiological aspects, Adenosine triphosphate -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the indolocarbazole C12 carbon analogue. The cyclization and alkylation of this analogue have been carried out via the solution-phase and solid-phase methods to prepare ATP competitive kinase inhibitors and the details are reported.

Published
2002

9. Total synthesis of dysiherbaine

Author

Phillips, Dean and Chamberlin, A. Richard

Subjects
Chemistry, Organic -- Research, Alkylation -- Physiological aspects, Glutamate -- Physiological aspects, Carbon -- Physiological aspects, Ring formation (Chemistry) -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the dysiherbaine. The synthesis of this marine natural product has been carried out and the alkylation at the protected glutamate gamma-carbon and the ring-contraction cascade reaction are described.

Published
2002

10. Asymmetric total synthesis of (+)-brefeldin A from (S)-lactate by triple chirality transfer process and nitrile oxide cycloaddition

Author

Deukjoon Kim, Jongkook Lee, Phil Jong Shim, Joong Inn Lim, Hyunil Jo, and Sanghee Kim

Subjects
Chemistry, Organic -- Research, Ring formation (Chemistry) -- Physiological aspects, Lactates -- Physiological aspects, Nitriles -- Physiological aspects, Oxides -- Physiological aspects, Alkylation -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the (+)-brefeldin A, a macrolide fungal metabolite. The synthesis of this metabolite has been carried out via different methods including intramolecular ester enolate alkylation and nitra- and intermolecular nitrile oxide cycloaddition and the results are reported.

Published
2002

11. A tandem Michael addition ring-closure route to the metabotropic receptor ligand alpha-(hydroxymethyl)glutamic acid and its gamma-alkylated derivatives

Author

Zhang, Jiazhong, Flippen-Anderson, Judith L., and Kozikowski, Alan P.

Subjects
Chemistry, Organic -- Research, Glutamate -- Physiological aspects, Ligands -- Physiological aspects, Ring formation (Chemistry) -- Physiological aspects, Alkylation -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the L-glutamate, an amino acid that acts on the ionotropic and metabotropic glutamate receptor family members. Results indicate that a 2-substituted L-glutamate analogue can act as a potent agonist of the metabotropic glutamate receptor-3 while functioning as a weak antagonist of metabotropic glutamate receptor-2.

Published
2001

12. Intramolecular cyclizations of imines bearing the 2-(thiomethyl)-3-trimethylsilyl-1-propenyl terminator. An efficient new procedure for the stereocontrolled synthesis of functionalized pyrrolidine derivatives

Author

Duncan, David and Livinghouse, Tom

Subjects
Chemistry, Organic -- Research, Alkylation -- Physiological aspects, Carbon -- Physiological aspects, Ring formation (Chemistry) -- Physiological aspects, Sulfides -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the allysilane terminator for the intramolecular imine-alkylation. The electronic modification of this terminator that provides cyclization stereocontrol under mild reaction conditions is described.

Published
2001

13. Asymmetric synthesis of cis-1,2-dialkenyl-substituted cyclopentanes via (-)-sparteine-mediated lithiation and cycloalkylation of a 9-chloro-2,7-nonadienyl carbamate

Author

Deiters, Alexander and Hoppe, Dieter

Subjects
Chemistry, Organic -- Research, Cyclic compounds -- Physiological aspects, Sparteine -- Physiological aspects, Lithium -- Physiological aspects, Alkylation -- Physiological aspects, Ring formation (Chemistry) -- Physiological aspects, Chlorine -- Physiological aspects, Carbamates -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the leaving group allylic substitution by carbon nucleophiles. The enantioselective synthesis of cyclopentane carried out via the stereogenic allyllithium compounds has been carried out and the results of the cycloalkylation reaction are presented.

Published
2001

14. Practical synthesis of 1,3-O-di-tert-butylsilylene-protected D- and L-erythritols as a four-carbon chiral building block

Author

Mori, Yuji and Hayashi, Hisafumi

Subjects
Chemistry, Organic -- Research, Carbon -- Physiological aspects, Anions -- Physiological aspects, Ether -- Physiological aspects, Toxins -- Physiological aspects, Alkylation -- Physiological aspects, Ring formation (Chemistry) -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the marine polycyclic ether toxins. The oxiranyl anion and 6-endo cyclization alkylation strategy used in developing an iterative approach to the trans-fused polytetrahydropyrans is described.

Published
2001

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