1. Charting the "Splice" Routes to MDS.
- Author
-
Obeng EA and Ebert BL
- Subjects
- Animals, Humans, Cell Differentiation genetics, Exons, Hematopoiesis genetics, Mutation, Myelodysplastic Syndromes genetics, Nuclear Proteins genetics, RNA Precursors genetics, RNA Splicing genetics, RNA, Messenger genetics, Ribonucleoproteins genetics, Telomere
- Abstract
Mutations in components of the 3' mRNA splicing machinery are found in almost 50% of myelodysplastic syndrome (MDS) cases. In this issue of Cancer Cell, Kim and colleagues, Colla and colleagues, and Shirai and colleagues report on the impact of mutated or dysregulated splicing factors to hematopoiesis, mRNA splicing, and MDS pathogenesis., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
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