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Your search keyword '"S. Venkatasubramaniam"' showing total 3 results
Start Over Author "S. Venkatasubramaniam" Topic rotavirus infections
3 results on '"S. Venkatasubramaniam"'

1. Multicenter, hospital-based surveillance of rotavirus disease and strains among indian children aged <5 years.

Author

Kang G, Arora R, Chitambar SD, Deshpande J, Gupte MD, Kulkarni M, Naik TN, Mukherji D, Venkatasubramaniam S, Gentsch JR, Glass RI, and Parashar UD

Subjects
Acute Disease, Child, Preschool, Female, Genotype, Hospitalization statistics & numerical data, Humans, India epidemiology, Infant, Infant, Newborn, Male, Rotavirus classification, Rotavirus Infections virology, Gastroenteritis epidemiology, Rotavirus Infections epidemiology
Abstract

Background: Current, nationally representative data on rotavirus disease burden and rotavirus strains in India are needed to understand the potential health benefits of rotavirus vaccination., Methods: The Indian Rotavirus Strain Surveillance Network was established with 4 laboratories and 10 hospitals in 7 different regions of India. At each hospital, children aged <5 years who presented with acute gastroenteritis and required hospitalization with rehydration for at least 6 h were enrolled. A fecal specimen was obtained and was tested for rotavirus with use of a commercial enzyme immunoassay, and strains were characterized using reverse-transcription polymerase chain reaction., Results: From December 2005 through November 2007, rotavirus was found in approximately 39% of 4243 enrolled patients. Rotavirus was markedly seasonal in northern temperate locations but was less seasonal in southern locations with a tropical climate. Rotavirus detection rates were greatest among children aged 6-23 months, and 13.3% of rotavirus infections involved children aged <6 months. The most common types of strains were G2P[4] (25.7% of strains), G1P[8] (22.1%), and G9P[8] (8.5%); G12 strains were seen in combination with types P[4], P[6], and P[8] and together comprised 6.5% of strains., Conclusions: These data highlight the need for development and implementation of effective prophylactic measures, such as vaccines, to prevent the large burden of rotavirus disease among Indian children.

Published
2009
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2. Diversity of circulating rotavirus strains in children hospitalized with diarrhea in India, 2005–2009

Author

Jon R. Gentsch, Shobha Chitamabar, Thuppal V. Sowmynarayanan, Indira Agarwal, Preeti Chhabra, Alka Jadhav, Ritu Arora, Sushmita J. Shetty, Anuradha Bose, Prabhakar D. Moses, Sasirekha Ramani, Jyoti Bhatt, Prachi Fadnis, Rishi Desai, Jagdish Deshpande, S. Venkatasubramaniam, Anna Simon, Ng Brajachand Singh, Ann Mathew, Gagandeep Kang, Soumyabrata Roy, Mohan D. Gupte, Rashmi Arora, Meenakshi Mathur, Anupam Mukherjee, Umesh D. Parashar, Triveni Krishnan, Sr. Anita, Vinay Kumar Saxena, and T. N. Naik

Subjects
Diarrhea, Rotavirus, medicine.medical_specialty, Genotype, viruses, India, Rotavirus Infections, Rotavirus vaccination, medicine.disease_cause, Polymerase Chain Reaction, Rotavirus disease, fluids and secretions, Epidemiology, medicine, Humans, General Veterinary, General Immunology and Microbiology, business.industry, Vaccination, Public Health, Environmental and Occupational Health, Infant, virus diseases, Vaccine introduction, Virology, Gastroenteritis, Hospitalization, Infectious Diseases, Child, Preschool, Molecular Medicine, medicine.symptom, business, Strain monitoring
Abstract

India accounts for 22% of the 453,000 global rotavirus deaths among children5 years annually. The Indian Rotavirus Strain Surveillance Network provides clinicians and public health partners with valuable rotavirus disease surveillance data. Our analysis offers policy-makers an update on rotavirus disease burden with emphasis on regional shifts in rotavirus strain epidemiology in India.Children5 years requiring hospitalization for acute gastroenteritis were selected from 10 representative hospitals in 7 cities throughout India between November 2005 through June 2009. We used a modified World Health Organization protocol for rotavirus surveillance; stool specimens were collected and tested for rotavirus using enzyme immunoassay and reverse-transcription polymerase chain reaction.A total of 7285 stool specimens collected were tested for rotavirus, among which 2899 (40%) were positive for rotavirus. Among the 2899 rotavirus detections, a G-type could not be determined for 662 (23%) and more than one G type was detected in 240 (8%). Of 1997 (69%) patients with only one G-type, the common types were G1 (25%), G2 (21%), G9 (13%), and G12 (10%). The proportion of rotavirus infections attributed to G12 infections rose from 8% to 39% in the Northern region and from 8% to 24% in the Western region.This study highlights the large, ongoing burden of rotavirus disease in India, as well as interesting regional shifts in rotavirus strain epidemiology, including an increasing detection of G12 rotavirus strains in some regions. While broad heterotypic protection from rotavirus vaccination is expected based on pre- and post-licensure data from other settings, effectiveness assessments and rotavirus strain monitoring after vaccine introduction will be important.

Published
2013

3. Multicenter, hospital-based surveillance of rotavirus disease and strains among indian children aged5 years

Author

Gagandeep, Kang, Rashmi, Arora, Shobha D, Chitambar, Jagdish, Deshpande, M D, Gupte, Madhuri, Kulkarni, Trilok N, Naik, Dipali, Mukherji, S, Venkatasubramaniam, Jon R, Gentsch, Roger I, Glass, Umesh D, Parashar, and Ng Brajachand, Singh

Subjects
Male, Rotavirus, medicine.medical_specialty, Genotype, viruses, Prevalence, Reoviridae, India, medicine.disease_cause, Rotavirus Infections, Internal medicine, Epidemiology, Immunology and Allergy, Medicine, Humans, Feces, biology, business.industry, Infant, Newborn, virus diseases, Infant, biology.organism_classification, Virology, Gastroenteritis, Vaccination, Hospitalization, Infectious Diseases, Immunization, El Niño, Child, Preschool, Acute Disease, Female, business
Abstract

BACKGROUND Current, nationally representative data on rotavirus disease burden and rotavirus strains in India are needed to understand the potential health benefits of rotavirus vaccination. METHODS The Indian Rotavirus Strain Surveillance Network was established with 4 laboratories and 10 hospitals in 7 different regions of India. At each hospital, children aged

Published
2009

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